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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2011

01-07-2011 | Original Paper

Population- and Family-Based Studies Associate the MTHFR Gene with Idiopathic Autism in Simplex Families

Auteurs: Xudong Liu, Fatima Solehdin, Ira L. Cohen, Maripaz G. Gonzalez, Edmund C. Jenkins, M. E. Suzanne Lewis, Jeanette J. A. Holden

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2011

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Abstract

Two methylenetetrahydrofolate reductase gene (MTHFR) functional polymorphisms were studied in 205 North American simplex (SPX) and 307 multiplex (MPX) families having one or more children with an autism spectrum disorder. Case–control comparisons revealed a significantly higher frequency of the low-activity 677T allele, higher prevalence of the 677TT genotype and higher frequencies of the 677T-1298A haplotype and double homozygous 677TT/1298AA genotype in affected individuals relative to controls. Family-based association testing demonstrated significant preferential transmission of the 677T and 1298A alleles and the 677T-1298A haplotype to affected offspring. The results were not replicated in MPX families. The results associate the MTHFR gene with autism in SPX families only, suggesting that reduced MTHFR activity is a risk factor for autism in these families.
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Metagegevens
Titel
Population- and Family-Based Studies Associate the MTHFR Gene with Idiopathic Autism in Simplex Families
Auteurs
Xudong Liu
Fatima Solehdin
Ira L. Cohen
Maripaz G. Gonzalez
Edmund C. Jenkins
M. E. Suzanne Lewis
Jeanette J. A. Holden
Publicatiedatum
01-07-2011
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2011
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-010-1120-x

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