Skip to main content
Top
Gepubliceerd in: Research on Child and Adolescent Psychopathology 6/2020

17-03-2020

Placental Gene Expression and Offspring Temperament Trajectories: Predicting Negative Affect in Early Childhood

Auteurs: J. Finik, J. Buthmann, W. Zhang, K. Go, Y. Nomura

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 6/2020

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Exposure to prenatal stress increases offspring risk for long-term neurobehavioral impairments and psychopathology, such as Attention Deficit Hyperactivity Disorder (ADHD). Epigenetic regulation of glucocorticoid pathway genes may be a potential underlying mechanism by which maternal conditions ‘program’ the fetal brain for downstream vulnerabilities. The present study aims to investigate whether mRNA expression of glucocorticoid pathway genes in the placenta predict offspring negative affect during early childhood (between 6 and 24 months). Participants include 318 mother-child dyads participating in a longitudinal birth cohort study. Placental mRNA expression of glucocorticoid pathway genes (HSD11B1, HSD11B2, NR3C1, NCOR2) were profiled and negative affect traits of the offspring were measured at 6, 12, 18, and 24 months. HSD11B1 mRNA expression significantly predicted negative affect (β = −.09, SE = .04; p = .036), and Distress to Limitations trajectories (β = −.13, SE = .06; p = .016). NCOR2 mRNA expression significantly predicted Distress to Limitations (β = .43, SE = .21; p = .047), and marginally predicted Sadness trajectories (β = .39, SE = .21; p = .068). HSD11B2 and NR3C1 did not predict trajectories of Negative Affect or subscale scores. Infant negative affect traits were assessed via maternal self-report, and deviated from linearity across follow-up. mRNA expression of glucocorticoid pathway genes in the placenta may be a potentially novel tool for early identification of infants at greater risk for elevated negative affect. Further study is needed to validate the utility of mRNA expression of glucocorticoid pathway genes in the placenta.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference Appleton, A. A., Lester, B. M., Armstrong, D. A., Lesseur, C., & Marsit, C. J. (2015). Examining the joint contribution of placental NR3C1 and HSD11B2 methylation for infant neurobehavior. Psychoneuroendocrinology, 52, 32–42.PubMed Appleton, A. A., Lester, B. M., Armstrong, D. A., Lesseur, C., & Marsit, C. J. (2015). Examining the joint contribution of placental NR3C1 and HSD11B2 methylation for infant neurobehavior. Psychoneuroendocrinology, 52, 32–42.PubMed
go back to reference Appleton, A. A., Holdsworth, E. A., & Ingle, M. E. (2016). Epigenetic Alterations to NR3C1 and HSD11B2 and the Developmental Origins of Mental Disease Risk. In Epigenetics and Neuroendocrinology (pp. 121–140). Cham: Springer. Appleton, A. A., Holdsworth, E. A., & Ingle, M. E. (2016). Epigenetic Alterations to NR3C1 and HSD11B2 and the Developmental Origins of Mental Disease Risk. In Epigenetics and Neuroendocrinology (pp. 121–140). Cham: Springer.
go back to reference Bergman, K., Sarkar, P., O’connor, T. G., Modi, N., Glover, V., & Connor, T. G. O. (2007). Maternal stress during pregnancy predicts cognitive ability and fearfulness in infancy. Journal of the American Academy of Child & Adolescent Psychiatry, 46(11), 1454–1463. https://doi.org/10.1097/chi.0b013e31814a62f6. Bergman, K., Sarkar, P., O’connor, T. G., Modi, N., Glover, V., & Connor, T. G. O. (2007). Maternal stress during pregnancy predicts cognitive ability and fearfulness in infancy. Journal of the American Academy of Child & Adolescent Psychiatry, 46(11), 1454–1463. https://​doi.​org/​10.​1097/​chi.​0b013e31814a62f6​.
go back to reference Braungart-Rieker, J. M., Hill-Soderlund, A. L., & Karrass, J. (2010). Fear and anger reactivity trajectories from 4 to 16 months: The roles of temperament, regulation, and maternal sensitivity. Developmental Psychology, 46(4), 791–804. https://doi.org/10.1037/a0019673.PubMed Braungart-Rieker, J. M., Hill-Soderlund, A. L., & Karrass, J. (2010). Fear and anger reactivity trajectories from 4 to 16 months: The roles of temperament, regulation, and maternal sensitivity. Developmental Psychology, 46(4), 791–804. https://​doi.​org/​10.​1037/​a0019673.PubMed
go back to reference Chen, S., Lu, W., Yueh, M.-F., Rettenmeier, E., Liu, M., Auwerx, J., et al. (2017). Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proceedings of the National Academy of Sciences of the United States of America, 114(8), E1432–E1440. https://doi.org/10.1073/1700214.PubMedPubMedCentral Chen, S., Lu, W., Yueh, M.-F., Rettenmeier, E., Liu, M., Auwerx, J., et al. (2017). Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proceedings of the National Academy of Sciences of the United States of America, 114(8), E1432–E1440. https://​doi.​org/​10.​1073/​1700214.PubMedPubMedCentral
go back to reference Ciesielski, T. H., Marsit, C. J., & Williams, S. M. (2015). Maternal psychiatric disease and epigenetic evidence suggest a common biology for poor fetal growth. BMC Pregnancy and Childbirth, 15(1). Ciesielski, T. H., Marsit, C. J., & Williams, S. M. (2015). Maternal psychiatric disease and epigenetic evidence suggest a common biology for poor fetal growth. BMC Pregnancy and Childbirth, 15(1).
go back to reference Cox, J. L., Holden, J. M., & Sagovsky, R. (1987). Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. The Journal of Mental Science, 150, 782–786. Cox, J. L., Holden, J. M., & Sagovsky, R. (1987). Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. The Journal of Mental Science, 150, 782–786.
go back to reference Davis, E. P., Glynn, L. M., Schetter, C. D., Hobel, C., Chicz-Demet, A., & Sandman, C. A. (2007). Prenatal exposure to maternal depression and cortisol influences infant temperament. Journal of the American Academy of Child & Adolescent Psychiatry, 46(6), 737–746. https://doi.org/10.1097/chi.0b013e318047b775. Davis, E. P., Glynn, L. M., Schetter, C. D., Hobel, C., Chicz-Demet, A., & Sandman, C. A. (2007). Prenatal exposure to maternal depression and cortisol influences infant temperament. Journal of the American Academy of Child & Adolescent Psychiatry, 46(6), 737–746. https://​doi.​org/​10.​1097/​chi.​0b013e318047b775​.
go back to reference Davis, E. P., Snidman, N., Wadhwa, P. D., Glynn, L. M., Schetter, C. D., & Sandman, C. A. (2004). Prenatal maternal anxiety and depression predict negative behavioral reactivity in infancy. Infancy, 6(3), 319–331. Davis, E. P., Snidman, N., Wadhwa, P. D., Glynn, L. M., Schetter, C. D., & Sandman, C. A. (2004). Prenatal maternal anxiety and depression predict negative behavioral reactivity in infancy. Infancy, 6(3), 319–331.
go back to reference Degnan, K. A., Almas, A. N., & Fox, N. A. (2010). Temperament and the environment in the etiology of childhood anxiety. Journal of Child Psychology and Psychiatry, 51(4), 497–517.PubMed Degnan, K. A., Almas, A. N., & Fox, N. A. (2010). Temperament and the environment in the etiology of childhood anxiety. Journal of Child Psychology and Psychiatry, 51(4), 497–517.PubMed
go back to reference Dekker, M. J. H. J., Tiemeier, H., Luijendijk, H. J., Kuningas, M., Hofman, A., de Jong, F. H., et al. (2012). The effect of common genetic variation in 11β-hydroxysteroid dehydrogenase type 1 on hypothalamic-pituitary-adrenal axis activity and incident depression. The Journal of Clinical Endocrinology and Metabolism, 97(2), E233–E237. https://doi.org/10.1210/jc.2011-0601.PubMed Dekker, M. J. H. J., Tiemeier, H., Luijendijk, H. J., Kuningas, M., Hofman, A., de Jong, F. H., et al. (2012). The effect of common genetic variation in 11β-hydroxysteroid dehydrogenase type 1 on hypothalamic-pituitary-adrenal axis activity and incident depression. The Journal of Clinical Endocrinology and Metabolism, 97(2), E233–E237. https://​doi.​org/​10.​1210/​jc.​2011-0601.PubMed
go back to reference Dougherty, L. R., Smith, V. C., Bufferd, S. J., Stringaris, A., Leibenluft, E., Carlson, G. A., & Klein, D. N. (2013). Preschool irritability: longitudinal associations with psychiatric disorders at age 6 and parental psychopathology. Journal of the American Academy of Child & Adolescent Psychiatry, 52(12), 1304–1313. Dougherty, L. R., Smith, V. C., Bufferd, S. J., Stringaris, A., Leibenluft, E., Carlson, G. A., & Klein, D. N. (2013). Preschool irritability: longitudinal associations with psychiatric disorders at age 6 and parental psychopathology. Journal of the American Academy of Child & Adolescent Psychiatry, 52(12), 1304–1313.
go back to reference Garstein, M., & Rothbart, M. K. (2003). Studying infant temperament via a revision of the Infant Behavior Questionnaire. Infant Behavior & Development, 26, 64–86. Garstein, M., & Rothbart, M. K. (2003). Studying infant temperament via a revision of the Infant Behavior Questionnaire. Infant Behavior & Development, 26, 64–86.
go back to reference Green, B. B., Armstrong, D. A., Lesseur, C., Paquette, A. G., Guerin, D. J., Kwan, L. E., & Marsit, C. J. (2015). The Role of Placental 11-Beta Hydroxysteroid Dehydrogenase Type 1 and Type 2 Methylation on Gene Expression and Infant Birth Weight1. Biology of Reproduction, 92(6). https://doi.org/10.1095/115.12806. Green, B. B., Armstrong, D. A., Lesseur, C., Paquette, A. G., Guerin, D. J., Kwan, L. E., & Marsit, C. J. (2015). The Role of Placental 11-Beta Hydroxysteroid Dehydrogenase Type 1 and Type 2 Methylation on Gene Expression and Infant Birth Weight1. Biology of Reproduction, 92(6). https://​doi.​org/​10.​1095/​115.​12806.
go back to reference Haselbeck, C., Niederberger, U., Kulle, A., Wache, K., Brauner, E., Gutermuth, M., et al. (2017). Prenatal maternal distress seems to be associated with the infant’s temperament and motor development: An explorative study. Journal of Neural Transmission, 124(7), 881–890. https://doi.org/10.1007/s00702-017-1712-0.PubMed Haselbeck, C., Niederberger, U., Kulle, A., Wache, K., Brauner, E., Gutermuth, M., et al. (2017). Prenatal maternal distress seems to be associated with the infant’s temperament and motor development: An explorative study. Journal of Neural Transmission, 124(7), 881–890. https://​doi.​org/​10.​1007/​s00702-017-1712-0.PubMed
go back to reference Holmes, M. C., Abrahamsen, C. T., French, K. L., Paterson, J. M., Mullins, J. J., & Seckl, J. R. (2006). The mother or the fetus? 11β-Hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids. Journal of Neuroscience, 26(14), 3840–3844.PubMed Holmes, M. C., Abrahamsen, C. T., French, K. L., Paterson, J. M., Mullins, J. J., & Seckl, J. R. (2006). The mother or the fetus? 11β-Hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids. Journal of Neuroscience, 26(14), 3840–3844.PubMed
go back to reference Janssen, A. B., Kertes, D. A., McNamara, G. I., Braithwaite, E. C., Creeth, H. D. J., Glover, V. I., & John, R. M. (2016). A Role for the Placenta in Programming Maternal Mood and Childhood Behavioural Disorders. Journal of Neuroendocrinology, 28(8). https://doi.org/10.1111/jne.12373. Janssen, A. B., Kertes, D. A., McNamara, G. I., Braithwaite, E. C., Creeth, H. D. J., Glover, V. I., & John, R. M. (2016). A Role for the Placenta in Programming Maternal Mood and Childhood Behavioural Disorders. Journal of Neuroendocrinology, 28(8). https://​doi.​org/​10.​1111/​jne.​12373.
go back to reference Kappil, M. A., Green, B. B., Armstrong, D. A., Sharp, A. J., Lambertini, L., Marsit, C. J., & Chen, J. (2015). Placental expression profile of imprinted genes impacts birth weight. Epigenetics, 10(9), 842–849.PubMedPubMedCentral Kappil, M. A., Green, B. B., Armstrong, D. A., Sharp, A. J., Lambertini, L., Marsit, C. J., & Chen, J. (2015). Placental expression profile of imprinted genes impacts birth weight. Epigenetics, 10(9), 842–849.PubMedPubMedCentral
go back to reference Lonigan, C. J., Phillips, B. M., & Hooe, E. S. (2003). Relations of positive and negative affectivity to anxiety and depression in children: evidence from a latent variable longitudinal study. Journal of Consulting and Clinical Psychology, 71(3), 465.PubMed Lonigan, C. J., Phillips, B. M., & Hooe, E. S. (2003). Relations of positive and negative affectivity to anxiety and depression in children: evidence from a latent variable longitudinal study. Journal of Consulting and Clinical Psychology, 71(3), 465.PubMed
go back to reference McTernan, C. L., Draper, N., Nicholson, H., Chalder, S. M., Driver, P., Hewison, M., et al. (2001). Reduced Placental 11β-Hydroxysteroid Dehydrogenase Type 2 mRNA Levels in Human Pregnancies Complicated by Intrauterine Growth Restriction: An Analysis of Possible Mechanisms. The Journal of Clinical Endocrinology & Metabolism, 86(10), 4979–4983. https://doi.org/10.1210/jcem.86.10.7893. McTernan, C. L., Draper, N., Nicholson, H., Chalder, S. M., Driver, P., Hewison, M., et al. (2001). Reduced Placental 11β-Hydroxysteroid Dehydrogenase Type 2 mRNA Levels in Human Pregnancies Complicated by Intrauterine Growth Restriction: An Analysis of Possible Mechanisms. The Journal of Clinical Endocrinology & Metabolism, 86(10), 4979–4983. https://​doi.​org/​10.​1210/​jcem.​86.​10.​7893.
go back to reference Mendoza, A., Astapova, I., Shimizu, H., Gallop, M. R., Al-Sowaimel, L., MacGowan, S. M. D., et al. (2017). NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor. Proceedings of the National Academy of Sciences, 114(40), E8458–E8467. Mendoza, A., Astapova, I., Shimizu, H., Gallop, M. R., Al-Sowaimel, L., MacGowan, S. M. D., et al. (2017). NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor. Proceedings of the National Academy of Sciences, 114(40), E8458–E8467.
go back to reference Morgan, S. A., McCabe, E. L., Gathercole, L. L., Hassan-Smith, Z. K., Larner, D. P., Bujalska, I. J., et al. (2014). 11 -HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess. Proceedings of the National Academy of Sciences, 111(24), E2482–E2491. https://doi.org/10.1073/pnas.1323681111. Morgan, S. A., McCabe, E. L., Gathercole, L. L., Hassan-Smith, Z. K., Larner, D. P., Bujalska, I. J., et al. (2014). 11 -HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess. Proceedings of the National Academy of Sciences, 111(24), E2482–E2491. https://​doi.​org/​10.​1073/​pnas.​1323681111.
go back to reference Muramatsu-Kato, K., Itoh, H., Kobayashi-Kohmura, Y., Murakami, H., Uchida, T., Suzuki, K., et al. (2014). Comparison between placental gene expression of 11β-hydroxysteroid dehydrogenases and infantile growth at 10 months of age: Placental 11βHSD and infantile growth. Journal of Obstetrics and Gynaecology Research, 40(2), 465–472. https://doi.org/10.1111/jog.12200.PubMed Muramatsu-Kato, K., Itoh, H., Kobayashi-Kohmura, Y., Murakami, H., Uchida, T., Suzuki, K., et al. (2014). Comparison between placental gene expression of 11β-hydroxysteroid dehydrogenases and infantile growth at 10 months of age: Placental 11βHSD and infantile growth. Journal of Obstetrics and Gynaecology Research, 40(2), 465–472. https://​doi.​org/​10.​1111/​jog.​12200.PubMed
go back to reference Muris, P., & Ollendick, T. H. (2005). The role of temperament in the etiology of child psychopathology. Clinical Child and Family Psychology Review, 8(4), 271–289.PubMed Muris, P., & Ollendick, T. H. (2005). The role of temperament in the etiology of child psychopathology. Clinical Child and Family Psychology Review, 8(4), 271–289.PubMed
go back to reference Murray, L., & Carothers, A. D. (1990). The validation of the Edinburgh Post-natal Depression Scale on a community sample. The British Journal of Psychiatry: the Journal of Mental Science, 157, 288–290. Murray, L., & Carothers, A. D. (1990). The validation of the Edinburgh Post-natal Depression Scale on a community sample. The British Journal of Psychiatry: the Journal of Mental Science, 157, 288–290.
go back to reference Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008). Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics, 3(2), 97–106.PubMed Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008). Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics, 3(2), 97–106.PubMed
go back to reference Palma-Gudiel, H., Cirera, F., Crispi, F., Eixarch, E., & Fañanás, L. (2018). The impact of prenatal insults on the human placental epigenome: A systematic review. Neurotoxicology and Teratology, 66, 80–93.PubMed Palma-Gudiel, H., Cirera, F., Crispi, F., Eixarch, E., & Fañanás, L. (2018). The impact of prenatal insults on the human placental epigenome: A systematic review. Neurotoxicology and Teratology, 66, 80–93.PubMed
go back to reference Plant, D. T., Pawlby, S., Pariante, C. M., & Jones, F. W. (2017). When one childhood meets another – maternal childhood trauma and offspring child psychopathology: A systematic review. Clinical Child Psychology and Psychiatry, 135910451774218. https://doi.org/10.1177/1359104517742186. Plant, D. T., Pawlby, S., Pariante, C. M., & Jones, F. W. (2017). When one childhood meets another – maternal childhood trauma and offspring child psychopathology: A systematic review. Clinical Child Psychology and Psychiatry, 135910451774218. https://​doi.​org/​10.​1177/​1359104517742186​.
go back to reference Ponder, K. L., Salisbury, A., McGonnigal, B., Laliberte, A., Lester, B., & Padbury, J. F. (2011). Maternal depression and anxiety are associated with altered gene expression in the human placenta without modification by antidepressant use: Implications for fetal programming. Developmental Psychobiology, 53(7), 711–723. https://doi.org/10.1002/dev.20549.PubMedPubMedCentral Ponder, K. L., Salisbury, A., McGonnigal, B., Laliberte, A., Lester, B., & Padbury, J. F. (2011). Maternal depression and anxiety are associated with altered gene expression in the human placenta without modification by antidepressant use: Implications for fetal programming. Developmental Psychobiology, 53(7), 711–723. https://​doi.​org/​10.​1002/​dev.​20549.PubMedPubMedCentral
go back to reference Prokopec, S. D., Watson, J. D., Waggott, D. M., Smith, A. B., Wu, A. H., Okey, A. B., & Boutros, P. C. (2012). Systematic evaluation of medium-throughput mRNA abundance platforms. RNA, 19(1), 51–62.PubMed Prokopec, S. D., Watson, J. D., Waggott, D. M., Smith, A. B., Wu, A. H., Okey, A. B., & Boutros, P. C. (2012). Systematic evaluation of medium-throughput mRNA abundance platforms. RNA, 19(1), 51–62.PubMed
go back to reference Putnam, S. P., Rothbart, M. K., & Gartstein, M. A. (2008). Homotypic and heterotypic continuity of fine-grained temperament during infancy, toddlerhood, and early childhood. Infant and Child Development, 17(4), 387–405. https://doi.org/10.1002/icd.582. Putnam, S. P., Rothbart, M. K., & Gartstein, M. A. (2008). Homotypic and heterotypic continuity of fine-grained temperament during infancy, toddlerhood, and early childhood. Infant and Child Development, 17(4), 387–405. https://​doi.​org/​10.​1002/​icd.​582.
go back to reference Räikkönen, K., Pesonen, A. K., O'reilly, J. R., Tuovinen, S., Lahti, M., Kajantie, E., et al. (2015). Maternal depressive symptoms during pregnancy, placental expression of genes regulating glucocorticoid and serotonin function and infant regulatory behaviors. Psychological Medicine, 45(15), 3217–3226.PubMed Räikkönen, K., Pesonen, A. K., O'reilly, J. R., Tuovinen, S., Lahti, M., Kajantie, E., et al. (2015). Maternal depressive symptoms during pregnancy, placental expression of genes regulating glucocorticoid and serotonin function and infant regulatory behaviors. Psychological Medicine, 45(15), 3217–3226.PubMed
go back to reference Reynolds, R. M., Pesonen, A.-K., O’Reilly, J. R., Tuovinen, S., Lahti, M., Kajantie, E., et al. (2015). Maternal depressive symptoms throughout pregnancy are associated with increased placental glucocorticoid sensitivity. Psychological Medicine, 45(10), 2023–2030. https://doi.org/10.1017/29171400316X.PubMed Reynolds, R. M., Pesonen, A.-K., O’Reilly, J. R., Tuovinen, S., Lahti, M., Kajantie, E., et al. (2015). Maternal depressive symptoms throughout pregnancy are associated with increased placental glucocorticoid sensitivity. Psychological Medicine, 45(10), 2023–2030. https://​doi.​org/​10.​1017/​29171400316X.PubMed
go back to reference Ruff, H. A., & Rothbart, M. K. (2001). Attention in early development: Themes and variations. Oxford University Press. Ruff, H. A., & Rothbart, M. K. (2001). Attention in early development: Themes and variations. Oxford University Press.
go back to reference Sarkar, S., Tsai, S.-W., Nguyen, T. T., Plevyak, M., Padbury, J. F., & Rubin, L. P. (2001). Inhibition of placental 11β-hydroxysteroid dehydrogenase type 2 by catecholamines via α-adrenergic signaling. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 281(6), R1966–R1974.PubMed Sarkar, S., Tsai, S.-W., Nguyen, T. T., Plevyak, M., Padbury, J. F., & Rubin, L. P. (2001). Inhibition of placental 11β-hydroxysteroid dehydrogenase type 2 by catecholamines via α-adrenergic signaling. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 281(6), R1966–R1974.PubMed
go back to reference Savage, J., Verhulst, B., Copeland, W., Althoff, R. R., Lichtenstein, P., & Roberson-Nay, R. (2015). A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms. Journal of the American Academy of Child & Adolescent Psychiatry, 54(5), 377–384. https://doi.org/10.1016/j.jaac.2015.02.010. Savage, J., Verhulst, B., Copeland, W., Althoff, R. R., Lichtenstein, P., & Roberson-Nay, R. (2015). A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms. Journal of the American Academy of Child & Adolescent Psychiatry, 54(5), 377–384. https://​doi.​org/​10.​1016/​j.​jaac.​2015.​02.​010.
go back to reference Shrout, P. E., & Fleiss, J. L. (1979). Intraclass correlations: Uses in assessing rater reliability. Psychological Bulletin, 86(2), 420–428.PubMed Shrout, P. E., & Fleiss, J. L. (1979). Intraclass correlations: Uses in assessing rater reliability. Psychological Bulletin, 86(2), 420–428.PubMed
go back to reference Stroud, L. R., Papandonatos, G. D., Parade, S. H., Salisbury, A. L., Phipps, M. G., Lester, B., et al. (2016). Prenatal major depressive disorder, placenta glucocorticoid and serotonergic signaling, and infant cortisol response. Psychosomatic Medicine, 78(9), 979.PubMedPubMedCentral Stroud, L. R., Papandonatos, G. D., Parade, S. H., Salisbury, A. L., Phipps, M. G., Lester, B., et al. (2016). Prenatal major depressive disorder, placenta glucocorticoid and serotonergic signaling, and infant cortisol response. Psychosomatic Medicine, 78(9), 979.PubMedPubMedCentral
go back to reference Tyrka, A. R., Parade, S. H., Welch, E. S., Ridout, K. K., Price, L. H., Marsit, C., et al. (2016). Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: Associations with early adversity and depressive, anxiety and substance-use disorders. Translational Psychiatry, 6(7), e848. https://doi.org/10.1038/tp.2016.112.PubMedPubMedCentral Tyrka, A. R., Parade, S. H., Welch, E. S., Ridout, K. K., Price, L. H., Marsit, C., et al. (2016). Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: Associations with early adversity and depressive, anxiety and substance-use disorders. Translational Psychiatry, 6(7), e848. https://​doi.​org/​10.​1038/​tp.​2016.​112.PubMedPubMedCentral
go back to reference van der Laan, S., Lachize, S. B., Vreugdenhil, E., de Kloet, E. R., & Meijer, O. C. (2008). Nuclear Receptor Coregulators Differentially Modulate Induction and Glucocorticoid Receptor-Mediated Repression of the Corticotropin-Releasing Hormone Gene. Endocrinology, 149(2), 725–732. https://doi.org/10.1210/en.2007-1234.PubMed van der Laan, S., Lachize, S. B., Vreugdenhil, E., de Kloet, E. R., & Meijer, O. C. (2008). Nuclear Receptor Coregulators Differentially Modulate Induction and Glucocorticoid Receptor-Mediated Repression of the Corticotropin-Releasing Hormone Gene. Endocrinology, 149(2), 725–732. https://​doi.​org/​10.​1210/​en.​2007-1234.PubMed
go back to reference Vrijsen, J. N., Vogel, S., Arias-Vásquez, A., Franke, B., Fernández, G., Becker, E. S., et al. (2015). Depressed patients in remission show an interaction between variance in the mineralocorticoid receptor NR3C2 gene and childhood trauma on negative memory bias. Psychiatric Genetics, 25(3), 99–105. https://doi.org/10.1097/YPG.0000000000000081.PubMed Vrijsen, J. N., Vogel, S., Arias-Vásquez, A., Franke, B., Fernández, G., Becker, E. S., et al. (2015). Depressed patients in remission show an interaction between variance in the mineralocorticoid receptor NR3C2 gene and childhood trauma on negative memory bias. Psychiatric Genetics, 25(3), 99–105. https://​doi.​org/​10.​1097/​YPG.​0000000000000081​.PubMed
go back to reference Welberg, L. A., Seckl, J. R., & Holmes, M. C. (2000). Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. The European Journal of Neuroscience, 12(3). Welberg, L. A., Seckl, J. R., & Holmes, M. C. (2000). Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. The European Journal of Neuroscience, 12(3).
go back to reference Yehuda, R., Engel, S. M., Brand, S. R., Seckl, J., Marcus, S. M., & Berkowitz, G. S. (2005). Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy. The Journal of Clinical Endocrinology & Metabolism, 90(7), 4115–4118. Yehuda, R., Engel, S. M., Brand, S. R., Seckl, J., Marcus, S. M., & Berkowitz, G. S. (2005). Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy. The Journal of Clinical Endocrinology & Metabolism, 90(7), 4115–4118.
go back to reference Zhang, W., Qian, L., Deyssenroth, M., Lambertini, L., Finik, J., Ham, J., et al. (2018). Timing of Prenatal Exposure to Trauma and Altered Placental Expressions of HPA-Axis Genes and Genes Driving Neurodevelopment. Journal of Neuroendocrinology, e12581. https://doi.org/10.1111/jne.125810. Zhang, W., Qian, L., Deyssenroth, M., Lambertini, L., Finik, J., Ham, J., et al. (2018). Timing of Prenatal Exposure to Trauma and Altered Placental Expressions of HPA-Axis Genes and Genes Driving Neurodevelopment. Journal of Neuroendocrinology, e12581. https://​doi.​org/​10.​1111/​jne.​125810.
Metagegevens
Titel
Placental Gene Expression and Offspring Temperament Trajectories: Predicting Negative Affect in Early Childhood
Auteurs
J. Finik
J. Buthmann
W. Zhang
K. Go
Y. Nomura
Publicatiedatum
17-03-2020
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 6/2020
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-020-00632-9

Andere artikelen Uitgave 6/2020

Research on Child and Adolescent Psychopathology 6/2020 Naar de uitgave