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Gepubliceerd in: Journal of Autism and Developmental Disorders 3/2016

06-10-2015 | Original Paper

Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies

Auteurs: Natascia Brondino, Laura Fusar-Poli, Cristina Panisi, Stefano Damiani, Francesco Barale, Pierluigi Politi

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2016

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Abstract

Autism spectrum disorders are an emerging health problem worldwide, but little is known about their pathogenesis. It has been hypothesized that autism may result from an imbalance between excitatory glutamatergic and inhibitory GABAergic pathways. Commonly used medications such as valproate, acamprosate, and arbaclofen may act on the GABAergic system and be a potential treatment for people with ASD. The present systematic review aimed at evaluating the state-of-the-art of clinical trials of GABA modulators in autism. To date there is insufficient evidence to suggest the use of these drugs in autistic subjects, even if data are promising. Of note, short-term use of all the reviewed medications appears to be safe. Future well designed trials are needed to elucidate these preliminary findings.
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Metagegevens
Titel
Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies
Auteurs
Natascia Brondino
Laura Fusar-Poli
Cristina Panisi
Stefano Damiani
Francesco Barale
Pierluigi Politi
Publicatiedatum
06-10-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-015-2619-y