Skip to main content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 11/2019

29-08-2019 | Original Paper

Pharmacologic Interventions for Irritability, Aggression, Agitation and Self-Injurious Behavior in Fragile X Syndrome: An Initial Cross-Sectional Analysis

Auteurs: Eleanor M. Eckert, Kelli C. Dominick, Ernest V. Pedapati, Logan K. Wink, Rebecca C. Shaffer, Howard Andrews, Tse-Hwei Choo, Chen Chen, Walter E. Kaufmann, Nicole Tartaglia, Elizabeth M. Berry-Kravis, Craig A. Erickson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2019

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Using a dataset involving 415 individuals with irritability, aggression, agitation and self-injury (IAAS) behaviors from the fragile X syndrome (FXS) FORWARD database, we describe the psychopharmacologic management of IAAS and features of the population of persons with FXS treated with drug therapy for IAAS. Among those with FXS exhibiting IAAS, individuals with FXS receiving drug treatment of IAAS were older, more predominantly male, have more significant intellectual disability, more like to have comorbid autism, hyperarousal, and social impairments. The most commonly utilized medications for IAAS in FXS are antipsychotic medications, specifically aripiprazole and risperidone (37% and 27%, respectively). The majority of subjects (63%) experienced no side effects noted from the use of their psychopharmacologic medications.
Literatuur
go back to reference Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. American Journal of Mental Deficiency, 5, 485–491. Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. American Journal of Mental Deficiency, 5, 485–491.
go back to reference Bailey, D. B., Jr., Hatton, D. D., Skinner, M., & Mesibov, G. (2001a). Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome. Journal of Autism and Developmental Disorders, 31(2), 165–174. CrossRef Bailey, D. B., Jr., Hatton, D. D., Skinner, M., & Mesibov, G. (2001a). Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome. Journal of Autism and Developmental Disorders, 31(2), 165–174. CrossRef
go back to reference Bailey, D. B., Jr., Mesibov, G. B., Hatton, D. D., Clark, R. D., Roberts, J. E., & Mayhew, L. (1998). Autistic behavior in young boys with fragile X syndrome. Journal of Autism and Developmental Disorders, 28(6), 499–508. CrossRef Bailey, D. B., Jr., Mesibov, G. B., Hatton, D. D., Clark, R. D., Roberts, J. E., & Mayhew, L. (1998). Autistic behavior in young boys with fragile X syndrome. Journal of Autism and Developmental Disorders, 28(6), 499–508. CrossRef
go back to reference Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L., et al. (2003). Validation of a brief quantitative measure of autistic traits: Comparison of the social responsiveness scale with the autism diagnostic interview-revised. Journal of Autism and Developmental Disorders, 33(4), 427–433. CrossRef Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L., et al. (2003). Validation of a brief quantitative measure of autistic traits: Comparison of the social responsiveness scale with the autism diagnostic interview-revised. Journal of Autism and Developmental Disorders, 33(4), 427–433. CrossRef
go back to reference Guy, W. (1976). ECDEU assessment manual for psychopharmacology. Publication no. 76-338. Washington, DC: U.S. DHEW, NIMH. Guy, W. (1976). ECDEU assessment manual for psychopharmacology. Publication no. 76-338. Washington, DC: U.S. DHEW, NIMH.
go back to reference Hatton, D. D., Bailey, D. B., Jr., Hargett-Beck, M. Q., Skinner, M., & Clark, R. D. (1999). Behavioral style of young boys with fragile X syndrome. Developmental Medicine and Child Neurology, 41(9), 625–632. CrossRef Hatton, D. D., Bailey, D. B., Jr., Hargett-Beck, M. Q., Skinner, M., & Clark, R. D. (1999). Behavioral style of young boys with fragile X syndrome. Developmental Medicine and Child Neurology, 41(9), 625–632. CrossRef
go back to reference Kaufmann, W. E., Abrams, M. T., Chen, W., & Reiss, A. L. (1999). Genotype, molecular phenotype, and cognitive phenotype: Correlations in fragile X syndrome. American Journal of Medical Genetics, 83(4), 286–295. CrossRef Kaufmann, W. E., Abrams, M. T., Chen, W., & Reiss, A. L. (1999). Genotype, molecular phenotype, and cognitive phenotype: Correlations in fragile X syndrome. American Journal of Medical Genetics, 83(4), 286–295. CrossRef
go back to reference McDougle, C. J., Stigler, K. A., Erickson, C. A., & Posey, D. J. (2008). Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders. Journal of Clinical Psychiatry, 69(Suppl 4), 15–20. PubMed McDougle, C. J., Stigler, K. A., Erickson, C. A., & Posey, D. J. (2008). Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders. Journal of Clinical Psychiatry, 69(Suppl 4), 15–20. PubMed
go back to reference Tsiouris, J. A., & Brown, W. T. (2004). Neuropsychiatric symptoms of fragile X syndrome: Pathophysiology and pharmacotherapy. CNS Drugs, 18(11), 687–703. CrossRef Tsiouris, J. A., & Brown, W. T. (2004). Neuropsychiatric symptoms of fragile X syndrome: Pathophysiology and pharmacotherapy. CNS Drugs, 18(11), 687–703. CrossRef
Metagegevens
Titel
Pharmacologic Interventions for Irritability, Aggression, Agitation and Self-Injurious Behavior in Fragile X Syndrome: An Initial Cross-Sectional Analysis
Auteurs
Eleanor M. Eckert
Kelli C. Dominick
Ernest V. Pedapati
Logan K. Wink
Rebecca C. Shaffer
Howard Andrews
Tse-Hwei Choo
Chen Chen
Walter E. Kaufmann
Nicole Tartaglia
Elizabeth M. Berry-Kravis
Craig A. Erickson
Publicatiedatum
29-08-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 11/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-019-04173-z

Andere artikelen Uitgave 11/2019

Journal of Autism and Developmental Disorders 11/2019 Naar de uitgave