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Research on Child and Adolescent Psychopathology

Gepubliceerd in:

01-07-2010

Personality Mediation of Genetic Effects on Attention-Deficit/Hyperactivity Disorder

Auteurs: Michelle M. Martel, Molly Nikolas, Katherine Jernigan, Karen Friderici, Joel T. Nigg

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 5/2010

Abstract

Personality traits may be viable candidates for mediators of the relationship between genetic risk and ADHD. Participants were 578 children (331 boys; 320 children with ADHD) between the ages of six and 18. Parents and teachers completed a comprehensive, multi-stage diagnostic procedure to assess ADHD and comorbid disorders. Mother completed the California Q-Sort to assess child Big Five personality traits. Children provided buccal samples of DNA which were assayed for selected markers on DRD4, DAT1, and ADRA2A. An additive genetic risk composite was associated with ADHD symptoms and maladaptive personality traits; maladaptive personality traits were associated with ADHD symptoms. Low conscientiousness and high neuroticism partially mediated the relationship between genetic risk and ADHD symptoms. Mediation effects for conscientiousness were specific to inattentive symptoms; effects for neuroticism generalized to all disruptive behaviors. High neuroticism and low conscientiousness may be useful as early markers for children at risk for ADHD.

vorige artikel Social Information Processing, Emotions, and Aggression: Conceptual and Methodological Contributions of the Special Section Articles

volgende artikel Inconsistent Self-Report of Delinquency by Adolescents and Young Adults with ADHD

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Titel: Personality Mediation of Genetic Effects on Attention-Deficit/Hyperactivity Disorder
Auteurs: Michelle M. Martel
Molly Nikolas
Katherine Jernigan
Karen Friderici
Joel T. Nigg
Publicatiedatum: 01-07-2010
Uitgeverij: Springer US
Gepubliceerd in: Research on Child and Adolescent Psychopathology / Uitgave 5/2010
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI: https://doi.org/10.1007/s10802-010-9392-3

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