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Gepubliceerd in: Quality of Life Research 11/2020

03-07-2020

Patterns of racial/ethnic disparities in baseline health-related quality of life and relationship with overall survival in patients with colorectal cancer

Auteurs: Alem A. Belachew, Monica E. Reyes, Yuanqing Ye, Gottumukkala S. Raju, M. Alma Rodriguez, Xifeng Wu, Michelle A. T. Hildebrandt

Gepubliceerd in: Quality of Life Research | Uitgave 11/2020

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Abstract

Purpose

Racial disparities are evident in colorectal cancer (CRC) prognosis with black patients experiencing worse outcomes than Hispanics and whites, yet mediators of these disparities are not fully known. The aim of this study is to identify variables that contribute to racial/ethnic disparities in health-related quality of life (HR-QoL) and overall survival in CRC.

Methods

Using SF-12 questionnaires, we assessed HR-QoL in 1132 CRC patients by calculating their physical (PCS) and mental composite summary (MCS) scores. Associations between poor PCS/MCS and sociodemographic factors were estimated and survival differences were identified by race/ethnicity.

Results

Hispanic patients who never married were at greater risk of poor PCS (OR 2.69; 95% CI 1.11–6.49; P = 0.028) than were currently married patients. College education was associated with a decreased risk of poor PCS in Hispanic and white, but not black, patients. Gender was significantly associated with poor MCS among white patients only. CRC patients who reported a poor PCS or MCS had poor survival, with differences in median survival times (MSTs) by race. The effect of PCS was strongest in white CRC patients with a difference in overall MST of > 116 months between those with favorable versus poor physical HR-QoL. Black patients who reported poor Physical and Mental HR-QoL showed significant risk of a poor outcome.

Conclusion

These findings suggest that racial/ethnic disparities in CRC survival may be related to differences in HR-QoL. Identified mediators of HR-QoL could supplement current CRC management strategies to improve patients’ survival.
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Metagegevens
Titel
Patterns of racial/ethnic disparities in baseline health-related quality of life and relationship with overall survival in patients with colorectal cancer
Auteurs
Alem A. Belachew
Monica E. Reyes
Yuanqing Ye
Gottumukkala S. Raju
M. Alma Rodriguez
Xifeng Wu
Michelle A. T. Hildebrandt
Publicatiedatum
03-07-2020
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 11/2020
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02565-8