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01-12-2008 | Uitgave 10/2008

Quality of Life Research 10/2008

Patient-reported outcomes and the mandate of measurement

Tijdschrift:
Quality of Life Research > Uitgave 10/2008
Auteur:
Gary Donaldson

Abstract

Purpose

Coherent clinical care depends on answering a basic question: is a patient getting worse, getting better, or staying about the same? This can prove surprisingly difficult to answer confidently. Patient-reported outcomes (PROs) could potentially help by providing quantifiable evidence. But quantifiable evidence is not necessarily good evidence, as this article details.

Method

The fundamental mandate of measurement requires that errors in making an assessment be smaller than the distinctions to be measured. This mandate implies that numerical observations of patients may be poor measurements.

Results

Individual assessments require high measurement precision and reliability. Group-averaged comparisons cancel out measurement error, but individual PROs do not. Individual PROs generate numbers, to be sure, but the numbers may fall short of what we should demand of measurements. When typical errors of measurement are large, it is not possible to answer confidently even the modest question of whether a patient is getting worse or getting better.

Conclusion

This article explains some theory behind the mandate of measurement, provides several examples based on clinical research, and suggests strategies to measure and monitor individual patient outcomes more precisely. These include more frequent low-burden assessments, more realistic confidence levels, and strengthened measurement that integrates population data.

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