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13-02-2017 | Review Article | Uitgave 4/2017 Open Access

Netherlands Heart Journal 4/2017

Pathophysiology and treatment of atherosclerosis

Current view and future perspective on lipoprotein modification treatment

Netherlands Heart Journal > Uitgave 4/2017
S. C. Bergheanu, M. C. Bodde, J. W. Jukema
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S.C. Bergheanu and M.C. Bodde contributed equally to the manuscript.


Recent years have brought a significant amount of new results in the field of atherosclerosis. A better understanding of the role of different lipoprotein particles in the formation of atherosclerotic plaques is now possible. Recent cardiovascular clinical trials have also shed more light upon the efficacy and safety of novel compounds targeting the main pathways of atherosclerosis and its cardiovascular complications.
In this review, we first provide a background consisting of the current understanding of the pathophysiology and treatment of atherosclerotic disease, followed by our future perspectives on several novel classes of drugs that target atherosclerosis. The focus of this update is on the pathophysiology and medical interventions of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and lipoprotein(a) (Lp(a)).

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Netherlands Heart Journal

Het Netherlands Heart Journal wordt uitgegeven in samenwerking met de Nederlandse Vereniging voor Cardiologie en de Nederlandse Hartstichting. Het tijdschrift is Engelstalig en wordt gratis beschikbaa ...

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