Swipe om te navigeren naar een ander artikel
Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger’s syndrome (n = 1,785) or other pervasive developmental disorder (PDD) (n = 1,796), which were ascertained from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Advanced paternal age (35–49 years) was associated with childhood autism in offspring, whereas advanced maternal age was associated with both Asperger’s syndrome and PDD in offspring (35 years or more and 40 years or more, respectively). Teenage motherhood (19 years or less) was associated with PDD in offspring. The main finding was that maternal and paternal ages were differentially associated with ASD subtypes. In addition to advanced parental age, teenage pregnancy seems to incur a risk for PDD in offspring.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Boden, J. M., Fergusson, D. M., & Horwood, L. J. (2010). Risk factors for conduct disorder and oppositional/defiant disorder: Evidence from a New Zealand birth cohort. Journal of the American Academy of Child and Adolescent Psychiatry, 49(11), 1125–1133. PubMed
Cleary-Goodman, J., Malone, F. D., Vidaver, J., Ball, R. H., Nyberg, D. A., Comstock, C. H., et al. (2005). Impact of maternal age on obstetric outcome. Obstetrics and Gynecology, 105(5 pt 1), 983–990. CrossRef
Fombonne, E., Du Mazaubrun, C., Cans, C., & Grandjean, H. (1997). Autism and associated medical disorders in a French epidemiological survey. Journal of the American Academy of Child and Adolescent Psychiatry, 36(11), 1561–1569. PubMed
Forss, A., & Säkkinen, S. (2012). Child maintenance and custody 2011. Recource document. National Institute for Health and Welfare. http://www.julkari.fi/bitstream/handle/10024/80498/Tr12_12.pdf. Accessed 11 December 2012.
Isohanni, M., Makikyro, T., Moring, J., Rasanen, P., Hakko, H., Partanen, U., et al. (1997). A comparison of clinical and research DSM-III-R diagnoses of schizophrenia in a Finnish national birth cohort. Clinical and research diagnoses of schizophrenia. Social Psychiatry and Psychiatric Epidemiology, 32(5), 303–308. PubMedCrossRef
Johnson, J. L., & Leff, M. (1999). Children of substance abusers: Overview of research findings. Pediatrics, 103(5 pt 2), 1085–1099. PubMed
Langley, K., Rice, F., van der Bree, M. B., & Thapar, A. (2005). Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review. Minerva Pediatrica, 57(9), 359–371. PubMed
Lauritsen, M. B., Pedersen, C. B., & Mortensen, P. B. (2005). Effects of familial risk factors and place of birth on the risk of autism: A nationwide register-based study. Journal of Child Psychology and Psychiatry and Allied Disciplines, 46(9), 963–971. CrossRef
Linnet, K. M., Dalsgaard, S., Obel, C., Wisborg, K., Henriksen, T. B., Rodriguez, A., et al. (2003). Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: Review of the current evidence. The American Journal of Psychiatry, 160(6), 1028–1040. PubMedCrossRef
Mahoney, W. J., Szatmari, P., MacLean, J. E., Bryson, S. E., Bartolucci, G., Walter, S. D., et al. (1998). Reliability and accuracy of differentiating pervasive developmental disorder subtypes. Journal of the American Academy of Child & Adolescent Psychiatry, 37(3), 278–285.
Moffitt, T. E., & E-Risk Study Team. (2002). Teen-aged mothers in contemporary Britain. Journal of Child Psychology and Psychiatry and Allied Disciplines, 43(6), 727–742. CrossRef
Pihkala, J., Hakala, T., Voutilainen, P., & Raivio, K. (1989). Characteristic of recent fetal growth curves in Finland. Duodecim, 105(8), 1540–1546. PubMed
Sasanfar, R., Haddad, S. A., Tolouei, A., Ghadami, M., Yu, D., & Santangelo, S. L. (2010). Paternal age increases the risk for autism in an Iranian population sample. Molecular Autism, 1(1), 2-2392-1-2.
Schanen, N. C. (2006). Epigenetics of autism spectrum disorders. Human molecular genetics, 15 Spec No 2, R138-50.
Smith, M., Spence, M. A., & Flodman, P. (2009). Nuclear and mitochondrial genome defects in autism. Annals of the New York Academy of Sciences, 2009(1151), 102–132. CrossRef
Tran, P. L., Lehti, V., Lampi, K. M., Helenius, H., Suominen, A., Gissler, M., et al. (2013). Smokin during pregnancy and risk of autism spectrum disorder in a finnish national birth cohort. Pediatric and Perinatal Epidemiology (in press).
Vuori, E., & Gissler, M. (2010). Births and newborns 2008. Statistical report 22/2009. National Institute for Health and Welfare. http://www.stakes.fi/tilastot/tilastotiedotteet/2010/Tr30_10.pdf. Accessed 15 December 2010.
World Health Organization. (1967). International classification of diseases, eight revision (ICD-8). Geneva: World Health Organization.
World Health Organization. (1977). International classification of diseases, ninth revision (ICD-9). Geneva: World Health Organization.
World Health Organization. (1992). International classification of diseases, 10th revision (ICD-10). Geneva: World Health Organization.
- Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort
Katja M. Lampi
Alan S. Brown
- Springer US