Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

Open Access 18-10-2016 | Original Paper

Parent-Endorsed Sex Differences in Toddlers with and Without ASD: Utilizing the M-CHAT

Auteurs: Roald A. Øien, Logan Hart, Synnve Schjølberg, Carla A. Wall, Elizabeth S. Kim, Anders Nordahl-Hansen, Martin R. Eisemann, Katarzyna Chawarska, Fred R. Volkmar, Frederick Shic

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2017

Abstract

Sex differences in typical development can provide context for understanding ASD. Baron-Cohen (Trends Cogn Sci 6(6):248–254, 2002) suggested ASD could be considered an extreme expression of normal male, compared to female, phenotypic profiles. In this paper, sex-specific M-CHAT scores from N = 53,728 18-month-old toddlers, including n = 185 (32 females) with ASD, were examined. Results suggest a nuanced view of the “extreme male brain theory of autism”. At an item level, almost every male versus female disadvantage in the broader population was consistent with M-CHAT vulnerabilities in ASD. However, controlling for total M-CHAT failures, this male disadvantage was more equivocal and many classically ASD-associated features were found more common in non-ASD. Within ASD, females showed relative strengths in joint attention, but impairments in imitation.

vorige artikel Overview and Preliminary Evidence for a Social Skills and Self-Care Curriculum for Adolescent Females with Autism: The Girls Night Out Model

volgende artikel Characteristics of Autism Spectrum Disorder in Sotos Syndrome

Alleen toegankelijk voor geautoriseerde gebruikers

American Academy of Pediatrics; Council on Children with Disabilities, Section on Developmental Behavioral Pediatrics, Bright Futures Steering Committee and Medical Home Initiatives for Children with Special Needs Project Advisory Committee. (2006). Identifying infants and young children with developmental disorders in the medical home: An algorithm for developmental surveillance and screening. Pediatrics, 118(1), 405–420.CrossRef

Asperger, H. (1944). Die ‘‘Autistischen Psychopathen’’ im Kindesalter. Archiv für Psychiatrie und Nervenkrankheiten, 117(1), 76–136.CrossRef

Auyeung, B., Lombardo, M., Knickmeyer, R., & Baron-Cohen, S. (2013). Extreme male brain (EMB) theory. Encyclopedia of Autism Spectrum Disorders, 1193–1202.

Baron-Cohen, S. (2002). The extreme male brain theory of autism. Trends in Cognitive Sciences, 6(6), 248–254.CrossRefPubMed

Baron-Cohen, S. (2009). Autism: The empathizing–systemizing (E–S) theory. Annals of the New York Academy of Sciences, 1156(1), 68–80.CrossRefPubMed

Baron-Cohen, S., & Benenson, J. F. (2003). Books and arts-essential difference: Men, women and the extreme male brain/essential difference: The truth about the male and female brain. Nature, 424(6945), 132–132.

Baron-Cohen, S., Knickmeyer, R. C., & Belmonte, M. K. (2005). Sex differences in the brain: Implications for explaining autism. Science, 310(5749), 819–823.CrossRefPubMed

Bölte, S., Duketis, E., Poustka, F., & Holtmann, M. (2011). Sex differences in cognitive domains and their clinical correlates in higher-functioning autism spectrum disorders. Autism. doi:10.1177/1362361310391116.PubMed

Bouchard, C., Trudeau, N., Sutton, A., Boudreault, M. C., & Deneault, J. (2009). Gender differences in language development in French Canadian children between 8 and 30 months of age. Applied Psycholinguistics, 30(04), 685–707.CrossRef

Boyle CA, Boulet S, Schieve L, Cohen RA, Blumberg SJ, Yeargin-Allsopp M, Visser S, Kogan MD. (2011). Trends in the prevalence of developmental disabilities in US children, 1997–2008. Pediatrics, 127, 1034–1042.CrossRefPubMed

Carter, A. S., Black, D. O., Tewani, S., Connolly, C. E., Kadlec, M. B., & Tager-Flusberg, H. (2007). Sex differences in toddlers with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37(1), 86–97.CrossRefPubMed

Connellan, J., Baron-Cohen, S., Wheelwright, S., Batki, A., & Ahluwalia, J. (2000). Sex differences in human neonatal social perception. Infant Behavior and Development, 23(1), 113–118.CrossRef

Davis, M. H. (1994). Empathy: A social psychological approach. Westview Press.

Dworzynski, K., Ronald, A., Bolton, P., & Happé, F. (2012). How different are girls and boys above and below the diagnostic threshold for autism spectrum disorders? Journal of the American Academy of Child & Adolescent Psychiatry, 51(8), 788–797.CrossRef

Fombonne, E. (2003). Epidemiological surveys of autism and other pervasive developmental disorders: An update. Journal of Autism and Developmental Disorders, 33(4), 365–382.CrossRefPubMed

Fombonne, E. (2005). The changing epidemiology of autism. Journal of Applied Research in Intellectual Disabilities, 18(4), 281–294.CrossRef

Fombonne, E. (2007). Epidemiological surveys of pervasive developmental disorders. In F. R. Volkmar (Ed.), Autism and pervasive developmental disorders (2nd ed., pp. 33–68). New York, NY: Cambridge University Press.CrossRef

Gilman, S. R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., & Vitkup, D. (2011). Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron, 70(5), 898–907.CrossRefPubMedPubMedCentral

Halpern, D. F. (1997). Sex differences in intelligence: Implications for education. American Psychologist, 52(10), 1091.CrossRefPubMed

Happé, F. G. (1995). The role of age and verbal ability in the theory of mind task performance of subjects with autism. Child Development, 66(3), 843–855.

Harrop, C., Shire, S., Gulsrud, A., Chang, Y. C., Ishijima, E., Lawton, K., & Kasari, C. (2015). Does gender influence core deficits in ASD? An investigation into social-communication and play of girls and boys with ASD. Journal of Autism and Developmental Disorders, 45(3), 766–777.CrossRefPubMed

Hattier, M. A., Matson, J. L., Tureck, K., & Horovitz, M. (2011). The effects of gender and age on repetitive and/or restricted behaviors and interests in adults with autism spectrum disorders and intellectual disability. Research in Developmental Disabilities, 32(6), 2346–2351.CrossRefPubMed

Hittelman, J. H., & Dickes, R. (1979). Sex differences in neonatal eye contact time. Merrill-Palmer Quarterly of Behavior and Development, 25, 171–184.

Ibanez, L. V., Stone, W. L. & Coonrod, E. E. (2014). Screening for autism in young children. In Handbook of autism and pervasive developmental disorders (4th ed., Vol. 2. pp. 585–608). Hoboken, NJ: Wiley.

Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., et al. (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. American Journal of Psychiatry, 167(7), 748–751.CrossRefPubMed

Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217–250.

Kopp, S., & Gillberg, C. (2011). The Autism Spectrum Screening Questionnaire (ASSQ)-Revised Extended Version (ASSQ-REV): An instrument for better capturing the autism phenotype in girls? A preliminary study involving 191 clinical cases and community controls. Research in Developmental Disabilities, 32(6), 2875–2888.CrossRefPubMed

Lai, D. C., Tseng, Y. C., Hou, Y. M., & Guo, H. R. (2012). Gender and geographic differences in the prevalence of autism spectrum disorders in children: Analysis of data from the national disability registry of Taiwan. Research in Developmental Disabilities, 33(3), 909–915.CrossRefPubMed

Levy, D., Ronemus, M., Yamrom, B., Lee, Y. H., Leotta, A., Kendall, J., et al. (2011). Rare de novo and transmitted copy-number variation in autistic spectrum disorders. Neuron, 70(5), 886–897.CrossRefPubMed

Lutchmaya, S., & Baron-Cohen, S. (2002). Human sex differences in social and non-social looking preferences, at 12 months of age. Infant Behavior and Development, 25(3), 319–325.CrossRef

Maccoby, E. E., & Jacklin, C. N. (1974). The psychology of sex differences (Vol. 1). Stanford: Stanford University Press.

Magnus, P., Irgens, L. M., Haug, K., Nystad, W., Skjærven, R., Stoltenberg, C., & MoBa Study Group. (2006). Cohort profile: The Norwegian mother and child cohort study (MoBa). International Journal of Epidemiology, 35(5), 1146–1150.CrossRefPubMed

Mandy, W., Chilvers, R., Chowdhury, U., Salter, G., Seigal, A., & Skuse, D. (2012). Sex differences in autism spectrum disorder: Evidence from a large sample of children and adolescents. Journal of Autism and Developmental Disorders, 42(7), 1304–1313.CrossRefPubMed

Mayes, S. D., & Calhoun, S. L. (2011). Impact of IQ, age, SES, gender, and race on autistic symptoms. Research in Autism Spectrum Disorders, 5(2), 749–757.CrossRef

McCarthy, P., Fitzgerald, M., & Smith, M. A. (1984). Prevalence of childhood autism in Ireland. Irish Medical Journal, 77(5), 129–130.PubMed

McClure, E. B. (2000). A meta-analytic review of sex differences in facial expression processing and their development in infants, children, and adolescents. Psychological Bulletin, 126(3), 424.CrossRefPubMed

Meltzoff, A. N., & Moore, M. K. (1983). Newborn infants imitate adult facial gestures. Child Development, 54, 702–709.CrossRefPubMed

Messinger, D. S., Young, G. S., Webb, S. J., Ozonoff, S., Bryson, S. E., Carter, A., et al. (2015). Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study. Molecular Autism, 6(1), 1.CrossRef

Montagne, B., Kessels, R. P., Frigerio, E., de Haan, E. H., & Perrett, D. I. (2005). Sex differences in the perception of affective facial expressions: Do men really lack emotional sensitivity? Cognitive Processing, 6(2), 136–141.CrossRefPubMed

Mundy, P., Block, J., Delgado, C., Pomares, Y., Van Hecke, A. V., & Parlade, M. V. (2007). Individual differences and the development of joint attention in infancy. Child Development, 78(3), 938–954.CrossRefPubMedPubMedCentral

Nilsen, R. M., Vollset, S. E., Gjessing, H. K., Skjærven, R., Melve, K. K., Schreuder, P., et al. (2009). Self-selection and bias in a large prospective pregnancy cohort in Norway. Paediatric and Perinatal Epidemiology, 23(6), 597–608.CrossRefPubMed

Reilly, S., Bavin, E. L., Bretherton, L., Conway, L., Eadie, P., Cini, E., et al. (2009). The Early Language in Victoria Study (ELVS): A prospective, longitudinal study of communication skills and expressive vocabulary development at 8, 12 and 24 months. International Journal of Speech and Language Pathology, 11(5), 344–357.CrossRef

Riddoch, C. J., Mattocks, C., Deere, K., Saunders, J., Kirkby, J., Tilling, K., et al. (2007). Objective measurement of levels and patterns of physical activity. Archives of Disease in Childhood, 92(11), 963–969.CrossRefPubMedPubMedCentral

Robins, D. L., Casagrande, K., Barton, M., Chen, C. M. A., Dumont-Mathieu, T., & Fein, D. (2014). Validation of the modified checklist for autism in toddlers, revised with follow-up (M-CHAT-R/F). Pediatrics, 133(1), 37–45.CrossRefPubMedPubMedCentral

Robins, D. L., Fein, D., Barton, M. L., & Green, J. A. (2001). The Modified Checklist for Autism in Toddlers: An initial study investigating the early detection of autism and pervasive developmental disorders. Journal of Autism and Developmental Disorders, 31(2), 131–144.CrossRefPubMed

Robinson, E. B., Lichtenstein, P., Anckarsäter, H., Happé, F., & Ronald, A. (2013). Examining and interpreting the female protective effect against autistic behavior. Proceedings of the National Academy of Sciences, 110(13), 5258–5262.CrossRef

Salomone, E., Charman, T., McConachie, H., & Warreyn, P. (2016). Child’s verbal ability and gender are associated with age at diagnosis in a sample of young children with ASD in Europe. Child: Care, Health and Development, 42(1), 141–145.

Skuse, D. H. (1997). Genetic factors in the etiology of child psychiatric disorders. Current Opinion in Pediatrics, 9(4), 360.CrossRef

Skuse, D. H. (2000). Imprinting, the X-chromosome, and the male brain: Explaining sex differences in the liability to autism. Pediatric Research, 47(1), 9–9.CrossRefPubMed

Solomon, M., Miller, M., Taylor, S. L., Hinshaw, S. P., & Carter, C. S. (2012). Autism symptoms and internalizing psychopathology in girls and boys with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42(1), 48–59.CrossRefPubMed

Stoltenberg, C., Schjølberg, S., Bresnahan, M., Hornig, M., Hirtz, D., Dahl, C., et al. (2010). The Autism Birth cohort: A paradigm for gene-environment-timing research. Molecular Psychiatry, 15, 676–680.CrossRefPubMedPubMedCentral

Surén, P., Bakken, I. J., Aase, H., Chin, R., Gunnes, N., Lie, K. K., et al. (2012). Autism spectrum disorder, ADHD, epilepsy, and cerebral palsy in Norwegian children. Pediatrics, 130(1), e152–e158.CrossRefPubMedPubMedCentral

Szatmari, P., Liu, X. Q., Goldberg, J., et al. (2012). Sex differences in repetitive stereotyped behaviors in autism: Implications for genetic liability. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 159B(1), 5–12.CrossRefPubMed

The Norwegian Mother and Child Cohort Study, End of enrolment—Protocol II, Revised October 2012 http://www.fhi.no/moba-en.

Trouton, A., Spinath, F. M., & Plomin, R. (2002). Twins early development study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood. Twin Research, 5(05), 444–448.CrossRefPubMed

Woodward, A. L., & Guajardo, J. J. (2002). Infants’ understanding of the point gesture as an object-directed action. Cognitive Development, 17(1), 1061–1084.CrossRef

Zahn-Waxler, C., Crick, N. R., Shirtcliff, E. A., & Woods, K. E. (2006). The origins and development of psychopathology in females and males. In D. Cicchetti & D. J. Cohen (Eds.), Developmental psychopathology: Theory and method (2nd ed., Vol. 1, pp. 76–138). Hoboken, NJ: Wiley.

Zambrana, I. M., Ystrom, E., & Pons, F. (2012). Impact of gender, maternal education, and birth order on the development of language comprehension: A longitudinal study from 18 to 36 months of age. Journal of Developmental & Behavioral Pediatrics, 33(2), 146–155.

Zwaigenbaum, L., Bryson, S. E., Szatmari, P., Brian, J., Smith, I. M., Roberts, W., et al. (2012). Sex differences in children with autism spectrum disorder identified within a high-risk infant cohort. Journal of Autism and Developmental Disorders, 42(12), 2585–2596.CrossRefPubMed

Titel: Parent-Endorsed Sex Differences in Toddlers with and Without ASD: Utilizing the M-CHAT
Auteurs: Roald A. Øien
Logan Hart
Synnve Schjølberg
Carla A. Wall
Elizabeth S. Kim
Anders Nordahl-Hansen
Martin R. Eisemann
Katarzyna Chawarska
Fred R. Volkmar
Frederick Shic
Publicatiedatum: 18-10-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-016-2945-8

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 1/2017

Parents Perceive Improvements in Socio-emotional Functioning in Adolescents with ASD Following Social Skills Treatment

Design and Cohort Characteristics of the Social Spectrum Study: A Multicenter Study of the Autism Spectrum Among Clinically Referred Children

The Use of Linguistic Cues in Sentence Comprehension by Mandarin-Speaking Children with High-Functioning Autism

Overview and Preliminary Evidence for a Social Skills and Self-Care Curriculum for Adolescent Females with Autism: The Girls Night Out Model

The Relationship Between Adverse Childhood Events, Resiliency and Health Among Children with Autism

Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD)