Skip to main content
Top

2021 | OriginalPaper | Hoofdstuk

14. Pancreas

Auteurs : Prof. dr. M. G. H. Besselink, Prof. dr. H. C. van Santvoort

Gepubliceerd in: Leerboek chirurgie

Uitgeverij: Bohn Stafleu van Loghum

share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Samenvatting

Dit hoofdstuk over het pancreas begint met een inleiding over embryologie, anatomie, fysiologie en beeldvormende diagnostiek (transabdominale echografie, CT, MRI, PET, endo-echografie, endoscopische retrograde cholangiopancreaticografie (ERCP) en diagnostische laparoscopie). Daarna worden de drie meest voorkomende afwijkingen besproken: acute pancreatitis, chronische pancreatitis (met name de behandeling van pijnklachten) en pancreastumoren. Veel aandacht gaat uit naar de verschillende pancreastumoren: pancreas ductaal adenocarcinoom (PDAC) van pancreaskop, het corpus en van de staart, periampullaire carcinomen zoals papil van Vater carcinoom, distaal cholangiocarcinoom en duodenumcarcinoom. Daarnaast komen intraductale papillaire mucineuze neoplasma (IPMN), de neuro-endocriene tumoren en overige tumoren aan bod. De beschikbare behandelingen worden voor tumoren in de pancreaskopregio belicht, om te beginnen de drie varianten van pancreatoduodenectomie: pylorussparende pancreatoduodenectomie (PPPD), pylorusresectie pancreatoduodenectomie (PRPD) en de klassieke Whipple-operatie.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference Arcidiacono PG, Calori G, Carrara S, McNicol ED, Testoni PA. Celiac plexus block for pancreatic cancer pain in adults. Cochrane Database Syst Rev 2011;3:CD007519. Arcidiacono PG, Calori G, Carrara S, McNicol ED, Testoni PA. Celiac plexus block for pancreatic cancer pain in adults. Cochrane Database Syst Rev 2011;3:CD007519.
go back to reference Bakker OJ, Brunschot S van, Santvoort HC van, Besselink MG, Bollen TL, Boermeester MA, et al.; Dutch Pancreatitis Study Group. Early versus on-demand nasoenteric tube feeding in acute pancreatitis. N Engl J Med. 201420;371(21):1983–93. Bakker OJ, Brunschot S van, Santvoort HC van, Besselink MG, Bollen TL, Boermeester MA, et al.; Dutch Pancreatitis Study Group. Early versus on-demand nasoenteric tube feeding in acute pancreatitis. N Engl J Med. 201420;371(21):1983–93.
go back to reference Besselink MG, Santvoort HC van, Buskens E, Boermeester MA, Goor H van, Timmerman HM, et al.; Dutch Acute Pancreatitis Study Group. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008;371(9613):651–9. Besselink MG, Santvoort HC van, Buskens E, Boermeester MA, Goor H van, Timmerman HM, et al.; Dutch Acute Pancreatitis Study Group. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008;371(9613):651–9.
go back to reference Bipat S, Phoa SS, Delden OM van, Bossuyt PM, Gouma DJ, Laméris JS, et al. Ultrasonography, computed tomography and magnetic resonance imaging for diagnosis and determining resectability of pancreatic adenocarcinoma: a metaanalysis. J Comput Assist Tomogr 2005;29(4):438–45. Bipat S, Phoa SS, Delden OM van, Bossuyt PM, Gouma DJ, Laméris JS, et al. Ultrasonography, computed tomography and magnetic resonance imaging for diagnosis and determining resectability of pancreatic adenocarcinoma: a metaanalysis. J Comput Assist Tomogr 2005;29(4):438–45.
go back to reference Cahen DL, Gouma DJ, Lamaree P, Nio Y, Rauws EA, Boermeester MA, et al. Long term outcome of endoscopic vs surgical drainage of the pancreatic suct in patients with chronic pancreatitis. Gastroenterology 2011;141(5):1690–5. Cahen DL, Gouma DJ, Lamaree P, Nio Y, Rauws EA, Boermeester MA, et al. Long term outcome of endoscopic vs surgical drainage of the pancreatic suct in patients with chronic pancreatitis. Gastroenterology 2011;141(5):1690–5.
go back to reference Cahen DL, Gouma DJ, Nio Y, Rauws EA, Boermeester MA, Busch OR, et al. Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis. New Engl J Med 2007;356(7):676–84. Cahen DL, Gouma DJ, Nio Y, Rauws EA, Boermeester MA, Busch OR, et al. Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis. New Engl J Med 2007;356(7):676–84.
go back to reference Conroy T, Hammel P, Hebbar M, Ben Abdelghani M, Wei AC, Raoul JL, et al; Canadian Cancer Trials Group and the Unicancer-GI–PRODIGE Group. FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer. N Engl J Med 2018;379(25):2395–406. Conroy T, Hammel P, Hebbar M, Ben Abdelghani M, Wei AC, Raoul JL, et al; Canadian Cancer Trials Group and the Unicancer-GI–PRODIGE Group. FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer. N Engl J Med 2018;379(25):2395–406.
go back to reference Da Costa DW, Bouwense SA, Schepers NJ, Besselink MG, Santvoort HC van, Brunschot S van, et al. Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial. Lancet 2015;386(10000):1261–8. Da Costa DW, Bouwense SA, Schepers NJ, Besselink MG, Santvoort HC van, Brunschot S van, et al. Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial. Lancet 2015;386(10000):1261–8.
go back to reference Diener MK, Fitzmaurice C, Schwarzer G, Seiler CM, Antes G, Knaebel HP, et al. Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma. Cochrane Database Syst Rev 2011;5:CD006053. Diener MK, Fitzmaurice C, Schwarzer G, Seiler CM, Antes G, Knaebel HP, et al. Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma. Cochrane Database Syst Rev 2011;5:CD006053.
go back to reference Dijk SM van, Hallensleben NDL, Santvoort HC van, Fockens P, Goor H van, Bruno MJ, et al.; Dutch Pancreatitis Study Group. Acute pancreatitis: recent advances through randomised trials. Gut 2017;66(11):2024–32. Dijk SM van, Hallensleben NDL, Santvoort HC van, Fockens P, Goor H van, Bruno MJ, et al.; Dutch Pancreatitis Study Group. Acute pancreatitis: recent advances through randomised trials. Gut 2017;66(11):2024–32.
go back to reference Gaag NA van der, Rauws EA, Eijck CH van, Bruno MJ, Harst E van der, Kubben FJ, et al. Preoperative biliary drainage for cancer of the head of the pancreas. New Engl J Med 2010;362(2):129–37. Gaag NA van der, Rauws EA, Eijck CH van, Bruno MJ, Harst E van der, Kubben FJ, et al. Preoperative biliary drainage for cancer of the head of the pancreas. New Engl J Med 2010;362(2):129–37.
go back to reference Hidalgo M. Pancreatic cancer. Review. New Engl J Med 2010;362(17):1605–17. Erratum in: New Engl J Med. 2010 Jul 15;363(3):298. Hidalgo M. Pancreatic cancer. Review. New Engl J Med 2010;362(17):1605–17. Erratum in: New Engl J Med. 2010 Jul 15;363(3):298.
go back to reference Neoptolemos JP, Palmer DH, Ghaneh P, Psarelli EE, Valle JW, Halloran CM, et al.; European Study Group for Pancreatic Cancer. Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. Lancet. 2017;389(10073):1011–24. Neoptolemos JP, Palmer DH, Ghaneh P, Psarelli EE, Valle JW, Halloran CM, et al.; European Study Group for Pancreatic Cancer. Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. Lancet. 2017;389(10073):1011–24.
go back to reference Pancreatic Section, British Society of Gastroenterology; Pancreatic Society of Great Britain and Ireland; Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland; Royal College of Pathologists; Special Interest Group for Gastro-Intestinal Radiology. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. Gut 2005;54(Suppl 5):v1–16. Pancreatic Section, British Society of Gastroenterology; Pancreatic Society of Great Britain and Ireland; Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland; Royal College of Pathologists; Special Interest Group for Gastro-Intestinal Radiology. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. Gut 2005;54(Suppl 5):v1–16.
go back to reference Pezzilli R, Zerbi A, Di Carlo V, Bassi C, Delle Fave GF; Working Group of the Italian Association for the Study of the Pancreas on Acute Pancreatitis. Practical guidelines for acute pancreatitis. Review. Pancreatology 2010;10(5):523–35. Pezzilli R, Zerbi A, Di Carlo V, Bassi C, Delle Fave GF; Working Group of the Italian Association for the Study of the Pancreas on Acute Pancreatitis. Practical guidelines for acute pancreatitis. Review. Pancreatology 2010;10(5):523–35.
go back to reference Santvoort HC van, Besselink MG, Bakker OJ, Hofker HS, Boermeester MA, Jong CH de, et al.; Dutch Pancreatitis Study Group. A step-up approach or open necrosectomy for necrotizing pancreatitis. New Engl J Med 2010;362(16):1491–502. Santvoort HC van, Besselink MG, Bakker OJ, Hofker HS, Boermeester MA, Jong CH de, et al.; Dutch Pancreatitis Study Group. A step-up approach or open necrosectomy for necrotizing pancreatitis. New Engl J Med 2010;362(16):1491–502.
go back to reference Schepers NJ, Bakker OJ, Besselink MG, Bollen TL, Dijkgraaf MG, Eijck CH van, et al.: Dutch Pancreatitis Study Group. Early biliary decompression versus conservative treatment in acute biliary pancreatitis (APEC trial): study protocol for a randomized controlled trial. Trials 2016;17:5. Schepers NJ, Bakker OJ, Besselink MG, Bollen TL, Dijkgraaf MG, Eijck CH van, et al.: Dutch Pancreatitis Study Group. Early biliary decompression versus conservative treatment in acute biliary pancreatitis (APEC trial): study protocol for a randomized controlled trial. Trials 2016;17:5.
go back to reference Yao L, Huang X, Li Y, Shi R, Zhang G. Prophylactic antibiotics reduce pancreatic necrosis in acute necrotizing pancreatitis: a meta-analysis of randomized trials. Dig Surg 2010;27(6):442–9. Yao L, Huang X, Li Y, Shi R, Zhang G. Prophylactic antibiotics reduce pancreatic necrosis in acute necrotizing pancreatitis: a meta-analysis of randomized trials. Dig Surg 2010;27(6):442–9.
go back to reference Zhang MM, Cheng JQ, Lu YR, Yi ZH, Yang P, Wu XT. Use of pre-, pro- and synbiotics in patients with acute pancreatitis: a meta-analysis. World J Gastroenterol 2010;16(31):3970–8. Zhang MM, Cheng JQ, Lu YR, Yi ZH, Yang P, Wu XT. Use of pre-, pro- and synbiotics in patients with acute pancreatitis: a meta-analysis. World J Gastroenterol 2010;16(31):3970–8.
Metagegevens
Titel
Pancreas
Auteurs
Prof. dr. M. G. H. Besselink
Prof. dr. H. C. van Santvoort
Copyright
2021
Uitgeverij
Bohn Stafleu van Loghum
DOI
https://doi.org/10.1007/978-90-368-2518-4_14