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Journal of Autism and Developmental Disorders

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04-01-2022 | Original Paper

Oxytocin Exposure in Labor and its Relationship with Cognitive Impairment and the Genetic Architecture of Autism

Auteurs: Alicia García-Alcón, Javier González-Peñas, Elisa Weckx, M. J. Penzol, Xaquín Gurriarán, Javier Costas, Covadonga M. Díaz-Caneja, Carmen Moreno, Patricia Hernández, Celso Arango, Mara Parellada

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2023

Abstract

Whether there is a relationship between oxytocin (OXT) use in labor and the risk of autism (ASD), and the nature of such relationship, is unclear. By integrating genetic and clinical data in a sample of 176 ASD participants, we tested the hypothesis that OXT is a marker for abnormal prenatal development which leads to impairments in the process of labor. OXT-exposed ASD had more obstetric complications (P = 0.031), earlier onset of symptoms (P = 0.027), poorer cognitive development (P = 0.011), higher mutation burden across neurodevelopment genes (P = 0.020; OR = 5.33) and lower transmission of polygenic risk for ASD (P = 0.0319), than non-exposed ASD. OXT seems to constitute a risk indicator rather than a risk factor for ASD, which is relevant for diagnostic and genetic counselling.

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Titel: Oxytocin Exposure in Labor and its Relationship with Cognitive Impairment and the Genetic Architecture of Autism
Auteurs: Alicia García-Alcón
Javier González-Peñas
Elisa Weckx
M. J. Penzol
Xaquín Gurriarán
Javier Costas
Covadonga M. Díaz-Caneja
Carmen Moreno
Patricia Hernández
Celso Arango
Mara Parellada
Publicatiedatum: 04-01-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05409-7

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