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Journal of Autism and Developmental Disorders

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01-08-2015 | S.I. : Emotion Regulation and Psychiatric Comorbidity in ASD

Overactive Pattern Separation Memory Associated with Negative Emotionality in Adults Diagnosed with Autism Spectrum Disorder

Auteurs: M. South, K. G. Stephenson, C. A. Nielson, M. Maisel, D. N. Top, C. B. Kirwan

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2015

Abstract

Bowler et al. (Journal of Autism and Developmental Disorders 44(9):2355–2362. doi:10.1007/s10803-014-2105-y, 2014) have suggested that a specific memory impairment in autism spectrum disorders (ASD) arises from hippocampal failure to consolidate multiple related pieces of information. Twenty-four adults diagnosed with ASD and matched healthy controls completed a pattern separation memory task that is known to critically depend on hippocampal involvement. They additionally completed questionnaires regarding anxiety, depression, and behavioral motivation. Specific deficits in pattern separation were significantly correlated with negative emotionality; the best predictor of memory deficit was from a measure of achievement motivation that has also been associated with hyperactivity and impulsivity. In the context of impaired emotion regulation in ASD, there is a need for integrated cognitive, affective, and neural systems approaches to build targeted interventions.

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Analyzing raw data resulted in the following additional significant results: group difference for the repeat-as-similar variable [ASD > TC; t(68) = 2.22, p = .03] and Pearson correlations between repeat-as-new variable and the STAI-T (r = .43, p = .04), (r = .47, p = .02) and BDI (r = .48, p = .02) in the ASD group. The multiple regression analyses did not show substantive differences between the raw and cleaned data.

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Titel: Overactive Pattern Separation Memory Associated with Negative Emotionality in Adults Diagnosed with Autism Spectrum Disorder
Auteurs: M. South
K. G. Stephenson
C. A. Nielson
M. Maisel
D. N. Top
C. B. Kirwan
Publicatiedatum: 01-08-2015
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-015-2547-x

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