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01-03-2015 | Original Paper

Outcomes in Adult Life Among Siblings of Individuals with Autism

Auteurs: Patricia Howlin, Philippa Moss, Sarah Savage, Patrick Bolton, Michael Rutter

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2015

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Abstract

Little is known about adult siblings of individuals with autism. We report on cognitive, social and mental health outcomes in 87 adult siblings (mean age 39 years). When younger all had been assessed either as being “unaffected” by autism (n = 69) or as meeting criteria for the “Broader Autism Phenotype” (BAP, n = 18). As adults, all scored within the average range on tests of intelligence, numeracy and literacy. “Unaffected” siblings were functioning well in terms of jobs, independence and social relationships. Levels of social relationships and employment were significantly lower in the BAP group; autism traits and mental health problems were significantly higher. The data suggest that the “broader autism phenotype” is a meaningful concept but more sensitive diagnostic measures are required.
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Literatuur
go back to reference Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., et al. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine, 25, 63–77.CrossRefPubMed Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., et al. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine, 25, 63–77.CrossRefPubMed
go back to reference Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5–17.CrossRefPubMed Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5–17.CrossRefPubMed
go back to reference Beck, A. T., Brown, G., & Steer, R. A. (1996). Beck depression inventory II manual. San Antonio, TX: The Psychological Corporation. Beck, A. T., Brown, G., & Steer, R. A. (1996). Beck depression inventory II manual. San Antonio, TX: The Psychological Corporation.
go back to reference Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893–897.CrossRefPubMed Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893–897.CrossRefPubMed
go back to reference Bolton, P., Macdonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., et al. (1994). A case-control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877–900.CrossRefPubMed Bolton, P., Macdonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., et al. (1994). A case-control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877–900.CrossRefPubMed
go back to reference Clark, D. A., Antony, M. M., Beck, A. T., Swinson, R. P., & Steer, R. A. (2005). Screening for obsessive and compulsive symptoms: Validation of the Clark-Beck obsessive-compulsive inventory. Psychological Assessment, 17, 132–143.CrossRefPubMed Clark, D. A., Antony, M. M., Beck, A. T., Swinson, R. P., & Steer, R. A. (2005). Screening for obsessive and compulsive symptoms: Validation of the Clark-Beck obsessive-compulsive inventory. Psychological Assessment, 17, 132–143.CrossRefPubMed
go back to reference Constantino, J. N., Lajonchere, C., Lutz, M., Gray, T., Abbacchi, A., McKenna, K., et al. (2006). Autistic social impairment in the siblings of children with pervasive developmental disorders. American Journal of Psychiatry, 163, 294–296.CrossRefPubMed Constantino, J. N., Lajonchere, C., Lutz, M., Gray, T., Abbacchi, A., McKenna, K., et al. (2006). Autistic social impairment in the siblings of children with pervasive developmental disorders. American Journal of Psychiatry, 163, 294–296.CrossRefPubMed
go back to reference Constantino, J. N., & Reiersen, A. (2008). Social responsiveness scale (adult informant- and self-report versions). Personal Communication. Constantino, J. N., & Reiersen, A. (2008). Social responsiveness scale (adult informant- and self-report versions). Personal Communication.
go back to reference Constantino, J. N., & Todd, R. D. (2005). Intergenerational transmission of subthreshold autistic traits in the general population. Biological Psychiatry, 57, 655–660.CrossRefPubMed Constantino, J. N., & Todd, R. D. (2005). Intergenerational transmission of subthreshold autistic traits in the general population. Biological Psychiatry, 57, 655–660.CrossRefPubMed
go back to reference Constantino, J. N., Zhang, Y. I., Frazier, T., Abbacchi, A. M., & Law, P. (2010). Sibling recurrence and the genetic epidemiology of autism. American Journal of Psychiatry, 167(11), 1349–1356.CrossRefPubMedCentralPubMed Constantino, J. N., Zhang, Y. I., Frazier, T., Abbacchi, A. M., & Law, P. (2010). Sibling recurrence and the genetic epidemiology of autism. American Journal of Psychiatry, 167(11), 1349–1356.CrossRefPubMedCentralPubMed
go back to reference Dawson, G., Estes, A., Munson, J., Schellenberg, G., Bernier, R., & Abbott, R. (2007). Quantitative assessment of autism symptom-related traits in probands and parents: Broader phenotype autism symptom scale. Journal of Autism and Developmental Disorders, 37(3), 523–536.CrossRefPubMed Dawson, G., Estes, A., Munson, J., Schellenberg, G., Bernier, R., & Abbott, R. (2007). Quantitative assessment of autism symptom-related traits in probands and parents: Broader phenotype autism symptom scale. Journal of Autism and Developmental Disorders, 37(3), 523–536.CrossRefPubMed
go back to reference Dunn, L. M., Dunn, L. M., Whetton, C., & Burley, J. (1997). The British picture vocabulary scale (2nd ed.). Windsor: NFER-NELSON. Dunn, L. M., Dunn, L. M., Whetton, C., & Burley, J. (1997). The British picture vocabulary scale (2nd ed.). Windsor: NFER-NELSON.
go back to reference Fombonne, E., Bolton, P., Prior, J., Jordan, H., & Rutter, M. (1997). A family study of autism: Cognitive patterns and levels in parents and siblings. Journal of Child Psychology and Psychiatry, 38, 667–683.CrossRefPubMed Fombonne, E., Bolton, P., Prior, J., Jordan, H., & Rutter, M. (1997). A family study of autism: Cognitive patterns and levels in parents and siblings. Journal of Child Psychology and Psychiatry, 38, 667–683.CrossRefPubMed
go back to reference Georgiades, S., Szatmari, P., Zwaigenbaum, L., Bryson, S., Brian, J., Roberts, W., et al. (2013). A prospective study of autistic-like traits in unaffected siblings of probands with autism spectrum disorder. JAMA Psychiatry, 70(1), 42–48.CrossRefPubMed Georgiades, S., Szatmari, P., Zwaigenbaum, L., Bryson, S., Brian, J., Roberts, W., et al. (2013). A prospective study of autistic-like traits in unaffected siblings of probands with autism spectrum disorder. JAMA Psychiatry, 70(1), 42–48.CrossRefPubMed
go back to reference Gerdts, J., Bernier, R., Dawson, G., & Estes, A. (2013). The Broader Autism phenotype in simplex and multiplex families. Journal of Autism and Developmental Disorders, 43(7), 1597–1605.CrossRefPubMed Gerdts, J., Bernier, R., Dawson, G., & Estes, A. (2013). The Broader Autism phenotype in simplex and multiplex families. Journal of Autism and Developmental Disorders, 43(7), 1597–1605.CrossRefPubMed
go back to reference Goldberg, D. P., & Williams, P. (1988). A user’s guide to the general health questionnaire. Windsor: NFER-Nelson. Goldberg, D. P., & Williams, P. (1988). A user’s guide to the general health questionnaire. Windsor: NFER-Nelson.
go back to reference Goodman, W. K., Price, L. H., Rasmussen, S. A., Mazure, C., Fleischmann, R. L., Hill, C. L., et al. (1989). The Yale-Brown obsessive compulsive scale. I. Development, use, and reliability. Archives in General Psychiatry, 46, 1006–1011.CrossRef Goodman, W. K., Price, L. H., Rasmussen, S. A., Mazure, C., Fleischmann, R. L., Hill, C. L., et al. (1989). The Yale-Brown obsessive compulsive scale. I. Development, use, and reliability. Archives in General Psychiatry, 46, 1006–1011.CrossRef
go back to reference Grønborg, T. K., Schendel, D. E., & Parner, E. T. (2013). Recurrence of autism spectrum disorders in full- and half- siblings and trends over time: A population based study. JAMA Pediatrics, 167(10), 947–953.CrossRefPubMed Grønborg, T. K., Schendel, D. E., & Parner, E. T. (2013). Recurrence of autism spectrum disorders in full- and half- siblings and trends over time: A population based study. JAMA Pediatrics, 167(10), 947–953.CrossRefPubMed
go back to reference Hastings, R. P. (2007). Longitudinal relationships between sibling behavioral adjustment and behavior problems of children with developmental disabilities. Journal of Autism and Developmental Disorders, 37(8), 1485–1492.CrossRefPubMed Hastings, R. P. (2007). Longitudinal relationships between sibling behavioral adjustment and behavior problems of children with developmental disabilities. Journal of Autism and Developmental Disorders, 37(8), 1485–1492.CrossRefPubMed
go back to reference Howlin, P., Moss, P., Savage, S., & Rutter, M. (2013). Social outcomes in mid to later adulthood among individuals diagnosed with autism and average non-verbal IQ as children. Journal of the American Academy of Child and Adolescent Psychiatry, 52(6), 572–581.CrossRefPubMed Howlin, P., Moss, P., Savage, S., & Rutter, M. (2013). Social outcomes in mid to later adulthood among individuals diagnosed with autism and average non-verbal IQ as children. Journal of the American Academy of Child and Adolescent Psychiatry, 52(6), 572–581.CrossRefPubMed
go back to reference Howlin, P., Moss, P., Savage, S., Tempier, A., & Rutter, M. (2014). Cognitive and language skills in adults with autism: A 40 year follow-up. Journal of Child Psychology and Psychiatry, 55(1), 49–58.CrossRefPubMed Howlin, P., Moss, P., Savage, S., Tempier, A., & Rutter, M. (2014). Cognitive and language skills in adults with autism: A 40 year follow-up. Journal of Child Psychology and Psychiatry, 55(1), 49–58.CrossRefPubMed
go back to reference Hurley, S. E., Losh, M., Parlier, M., Reznick, J. S., & Piven, J. (2007). The Broad Autism phenotype questionnaire. Journal of Autism and Developmental Disorders, 37, 1679–1690.CrossRefPubMed Hurley, S. E., Losh, M., Parlier, M., Reznick, J. S., & Piven, J. (2007). The Broad Autism phenotype questionnaire. Journal of Autism and Developmental Disorders, 37, 1679–1690.CrossRefPubMed
go back to reference Ingersoll, B., & Wainer, A. (2014). The Broader autism phenotype. In F. Volkmar, A., Klin, R. Paul, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders, 4th edn, Vol. 1 (pp 28–56). New York, NY: Wiley. Ingersoll, B., & Wainer, A. (2014). The Broader autism phenotype. In F. Volkmar, A., Klin, R. Paul, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders, 4th edn, Vol. 1 (pp 28–56). New York, NY: Wiley.
go back to reference Kessler, R. C., Adler, L., Ames, M., Demler, O., Faraone, S., Hiripi, E., et al. (2005). The World Health Organization Adult ADHD Self-Report Scale (ASRS): A short screening scale for use in the general population. Psychological Medicine, 35, 245–256.CrossRefPubMed Kessler, R. C., Adler, L., Ames, M., Demler, O., Faraone, S., Hiripi, E., et al. (2005). The World Health Organization Adult ADHD Self-Report Scale (ASRS): A short screening scale for use in the general population. Psychological Medicine, 35, 245–256.CrossRefPubMed
go back to reference Le Couteur, A., Bailey, A., Goode, S., Pickles, A., Robertson, S., Gottesman, I., et al. (1996). A broader phenotype of autism: the clinical spectrum in twins. Journal of Child Psychology and Psychiatry, 37, 785–801.CrossRefPubMed Le Couteur, A., Bailey, A., Goode, S., Pickles, A., Robertson, S., Gottesman, I., et al. (1996). A broader phenotype of autism: the clinical spectrum in twins. Journal of Child Psychology and Psychiatry, 37, 785–801.CrossRefPubMed
go back to reference Losh, M., Childress, D., Lam, K., & Piven, J. (2008). Defining key features of the broad autism phenotype: A comparison across parents of multiple- and single-incidence autism families. American Journal of Medical Genetics, Part B Neuropsychiatric Genetics, 147B(4), 424–433.CrossRef Losh, M., Childress, D., Lam, K., & Piven, J. (2008). Defining key features of the broad autism phenotype: A comparison across parents of multiple- and single-incidence autism families. American Journal of Medical Genetics, Part B Neuropsychiatric Genetics, 147B(4), 424–433.CrossRef
go back to reference National Child Development Survey: Sweep Six (NCDS6) 1999–2000 (2000) Centre for Longitudinal Studies, Institute of Education, University of London. National Child Development Survey: Sweep Six (NCDS6) 1999–2000 (2000) Centre for Longitudinal Studies, Institute of Education, University of London.
go back to reference Orsmond, G., Kuo, H.-Y., & Seltzer, M. M. (2009). Siblings of individuals with an autism spectrum disorder: Sibling relationships and wellbeing in adolescence and adulthood. Autism, 13(1), 59–80.CrossRefPubMedCentralPubMed Orsmond, G., Kuo, H.-Y., & Seltzer, M. M. (2009). Siblings of individuals with an autism spectrum disorder: Sibling relationships and wellbeing in adolescence and adulthood. Autism, 13(1), 59–80.CrossRefPubMedCentralPubMed
go back to reference Orsmond, G. I., & Seltzer, M. M. (2007). Siblings of individuals with autism spectrum disorders across the life course. Mental Retardation and Developmental Disabilities Research Reviews, 13, 313–320.CrossRefPubMed Orsmond, G. I., & Seltzer, M. M. (2007). Siblings of individuals with autism spectrum disorders across the life course. Mental Retardation and Developmental Disabilities Research Reviews, 13, 313–320.CrossRefPubMed
go back to reference Petalas, M. A., Hastings, R. P., Nash, S., Hall, L. M., Joannidi, H., & Dowey, A. (2012). Psychological adjustment and sibling relationships in siblings of children with autism spectrum disorders: Environmental stressors and the broad autism phenotype. Research in Autism Spectrum Disorders., 6(1), 546–555.CrossRef Petalas, M. A., Hastings, R. P., Nash, S., Hall, L. M., Joannidi, H., & Dowey, A. (2012). Psychological adjustment and sibling relationships in siblings of children with autism spectrum disorders: Environmental stressors and the broad autism phenotype. Research in Autism Spectrum Disorders., 6(1), 546–555.CrossRef
go back to reference Pickles, A., Parr, J. R., Rutter, M. L., De Jonge, M. V., Wallace, S., Le Couteur, A., et al. (2013). New interview and observation measures of the Broader Autism phenotype: Impressions of interviewee measure. Journal of Autism and Developmental Disorders, 43(9), 2082–2089.CrossRefPubMed Pickles, A., Parr, J. R., Rutter, M. L., De Jonge, M. V., Wallace, S., Le Couteur, A., et al. (2013). New interview and observation measures of the Broader Autism phenotype: Impressions of interviewee measure. Journal of Autism and Developmental Disorders, 43(9), 2082–2089.CrossRefPubMed
go back to reference Piven, J., Palmer, P., Jacobi, D., Childress, D., & Arndt, S. (1997). Broader autism phenotype: Evidence from a family history study of multiple-incidence autism families. American Journal of Psychiatry, 154(2), 185–190.CrossRefPubMed Piven, J., Palmer, P., Jacobi, D., Childress, D., & Arndt, S. (1997). Broader autism phenotype: Evidence from a family history study of multiple-incidence autism families. American Journal of Psychiatry, 154(2), 185–190.CrossRefPubMed
go back to reference Plumet, M. H., Goldblum, M. C., & Le Boyer, M. (1995). Verbal skills in relatives of autistic females. Cortex, 32, 723–733.CrossRef Plumet, M. H., Goldblum, M. C., & Le Boyer, M. (1995). Verbal skills in relatives of autistic females. Cortex, 32, 723–733.CrossRef
go back to reference Rutter, M., Le Couteur, A., & Lord, C. (2003). The autism diagnostic interview-revised. Los Angeles: Western Psychological Services. Rutter, M., Le Couteur, A., & Lord, C. (2003). The autism diagnostic interview-revised. Los Angeles: Western Psychological Services.
go back to reference Rutter, M., & Thapar, A. (2014). Genetics of autism spectrum disorders. In F. R. Volkmar, R. Paul, S. J. Rogers, & K. A. Pelphrey (Eds.), Handbook of autism and pervasive developmental disorders, 4th edn, Vol. II. (pp. 411–423). New Jersey: Wiley. Rutter, M., & Thapar, A. (2014). Genetics of autism spectrum disorders. In F. R. Volkmar, R. Paul, S. J. Rogers, & K. A. Pelphrey (Eds.), Handbook of autism and pervasive developmental disorders, 4th edn, Vol. II. (pp. 411–423). New Jersey: Wiley.
go back to reference Sanders, S. S., Murtha, M. T., Gupta, A. R., Murdoch, J. D., Raubeson, M. J., Willsey, A. J., et al. (2012). De novo mutations revealed by whole exome sequencing are strongly associated with autism. Nature, 485(7397), 237–241.CrossRefPubMedCentralPubMed Sanders, S. S., Murtha, M. T., Gupta, A. R., Murdoch, J. D., Raubeson, M. J., Willsey, A. J., et al. (2012). De novo mutations revealed by whole exome sequencing are strongly associated with autism. Nature, 485(7397), 237–241.CrossRefPubMedCentralPubMed
go back to reference Scahill, L., McDougle, C. J., Williams, S. K., Dimitropoulos, A., Aman, M. G., McCracken, J. T., et al. (2006). Children’s Yale-Brown obsessive compulsive scale modified for pervasive developmental disorders. Journal of American Academy of Child and Adolescent Psychiatry, 45, 1114–1123.CrossRef Scahill, L., McDougle, C. J., Williams, S. K., Dimitropoulos, A., Aman, M. G., McCracken, J. T., et al. (2006). Children’s Yale-Brown obsessive compulsive scale modified for pervasive developmental disorders. Journal of American Academy of Child and Adolescent Psychiatry, 45, 1114–1123.CrossRef
go back to reference Sucksmith, E., Roth, I., & Hoekstra, R. A. (2011). Autistic traits below the clinical threshold: Re-examining the broader autism phenotype in the 21st century. Neuropsychology Review, 21, 360–389.CrossRefPubMed Sucksmith, E., Roth, I., & Hoekstra, R. A. (2011). Autistic traits below the clinical threshold: Re-examining the broader autism phenotype in the 21st century. Neuropsychology Review, 21, 360–389.CrossRefPubMed
go back to reference Wechsler, D. (1999). The Wechsler abbreviated scale of intelligence. San Antonio, TX: The Psychological Corporation. Wechsler, D. (1999). The Wechsler abbreviated scale of intelligence. San Antonio, TX: The Psychological Corporation.
go back to reference Wechsler (2005). Individual achievement test, 2nd ed. (WIAT-II, UK). Oxford: Pearson Assessment. Wechsler (2005). Individual achievement test, 2nd ed. (WIAT-II, UK). Oxford: Pearson Assessment.
go back to reference Wechsler, D., Wycherley, R. J., & Benjamin, L. (1997). Wechsler adult intelligence scale: Administration manual (3rd ed.). UK: The Psychological Corporation. Wechsler, D., Wycherley, R. J., & Benjamin, L. (1997). Wechsler adult intelligence scale: Administration manual (3rd ed.). UK: The Psychological Corporation.
go back to reference Woolfenden, S., Sarkozy, V., Ridley, G., & Williams, K. (2012). A systematic review of the diagnostic stability of Autism Spectrum Disorder. Research in Autism Spectrum Disorders, 6, 345–354.CrossRef Woolfenden, S., Sarkozy, V., Ridley, G., & Williams, K. (2012). A systematic review of the diagnostic stability of Autism Spectrum Disorder. Research in Autism Spectrum Disorders, 6, 345–354.CrossRef
Metagegevens
Titel
Outcomes in Adult Life Among Siblings of Individuals with Autism
Auteurs
Patricia Howlin
Philippa Moss
Sarah Savage
Patrick Bolton
Michael Rutter
Publicatiedatum
01-03-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-014-2224-5