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Gepubliceerd in: Neuropraxis 3/2018

17-05-2018 | Artikel

Op zoek naar biomarkers van de alcoholkater

Auteurs: Marlou Mackus, Chantal G. Terpstra, Aurora J. A. E. van de Loo, Joris C. Verster

Gepubliceerd in: Neuropraxis | Uitgave 3/2018

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Samenvatting

De alcoholkater wordt gedefinieerd als de combinatie van mentale en fysieke symptomen die ervaren worden de dag na een stevige drinksessie, die start wanneer de bloedalcoholconcentratie de nulwaarde nadert. Dit artikel betreft een naturalistisch opgezet onderzoek naar de samenhang tussen de ernst van de alcoholkater en mogelijke biomarkers voor een alcoholkater, namelijk de urineconcentraties van ethanol, methanol, ethylglucuronide (EtG) en ethylsulfaat (EtS). Aan dit onderzoek deden 36 gezonde sociale drinkers mee (18 katersensitieve en 18 katerresistente drinkers). Van alle deelnemers werden op een postalcoholdag en op de controledag de urineconcentraties van ethanol, methanol, EtG en EtS bepaald. Deelnemers konden zelf hun controledag en postalcoholdag bepalen, evenals de hoeveelheid alcohol die zij consumeerden. Vervolgens is de correlatie tussen de urineconcentratie en de ernst van de alcoholkater berekend en gescoord op een schaal van 0 (afwezig) tot 10 (extreem erg). De correlatie tussen de ernst van de alcoholkater en de urineconcentraties waren niet significant. Wel correleerden de ethanol-urineconcentraties significant met de ernst van de alcoholkater. Verder onderzoek is nodig naar de pathologie van de alcoholkater en mogelijke biomarkers die significant correleren met de ernst van de kater.
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Metagegevens
Titel
Op zoek naar biomarkers van de alcoholkater
Auteurs
Marlou Mackus
Chantal G. Terpstra
Aurora J. A. E. van de Loo
Joris C. Verster
Publicatiedatum
17-05-2018
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 3/2018
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/s12474-018-00190-3

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