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Gepubliceerd in:

01-04-2008

Omega-3 fatty acids and multiple sclerosis: relationship to depression

Auteurs: Robin L. Aupperle, Douglas R. Denney, Sharon G. Lynch, Susan E. Carlson, Debra K. Sullivan

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 2/2008

Abstract

Depression is a common problem among patients with multiple sclerosis (MS). Previous research has shown differences between MS patients and controls in the levels of certain fatty acids, and differences in many of these same fatty acids have also been reported in psychiatric patients with major depression. The current study sought to determine whether fatty acid levels in MS patients might be associated with depression. Fatty acids were measured in red blood cells (RBCs) for 38 patients with relapsing-remitting MS and 33 healthy controls who also completed 3-day dietary records and depression questionnaires. Levels of certain omega-3 and omega-6 fatty acids were lower and levels of certain monounsaturated and saturated fatty acids were higher in the MS patients. These differences were generally of medium effect size and occurred despite the fact that no differences were found between the two groups in dietary intake of any fatty acids. However, neither RBC nor dietary fatty acid levels were related to depression in the MS sample.

vorige artikel Posttraumatic stress disorder, alcohol use, and physical health concerns

volgende artikel Symptoms of depression and impaired endothelial function in healthy adolescent women

Adams, P. B., Lawson, S., Sanigorski, A., & Sinclair, A. J. (1996). Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 31(Suppl), 157–161.CrossRef

Astorg, P., Arnault, N., Czernichow, S., Noisette, N., Galan, P., & Hercberg, S. (2004). Dietary intakes and food sources of n-6 and n-3 PUFA in French adult men and women. Lipids 39, 527–535.PubMedCrossRef

Bas, M., Altan, T., Dincer, D., Aran, E., Gulper Kaya, H., & Yuksek, O. (2005). Determination of dietary habits as a risk factor of cardiovascular heart disease in Turkish adolescents. European Journal of Nutrition 44, 174–182.PubMedCrossRef

Besler, H. T., & Comoğlu, S. (2003). Lipprotein oxidation, plasma total antioxidant capacity and homocysteine level in patients with multiple sclerosis. Nutritional Neuroscience 6, 189–196.PubMedCrossRef

Boullerne, A., Petty, K. G., & Geffard, M. (1996). Circulating antibodies directed against conjugated fatty acids in sera of patients with multiple sclerosis. Journal of Neuroimmunology 65, 75–81.PubMedCrossRef

Brownbill, R. A., Petrosian, M., & Ilich, J. Z. (2005). Association between dietary conjugated linoleic acid and bone mineral density in postmenopausal women. Journal of the American College of Nutrition 24, 177–181.PubMed

Carlson, S. E., Cooke, R. J., Rhodes, P. G., Peeples, J. M., Werkman, S. H., & Tolley, E. A. (1991). Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants: Phospholipid fatty acids. Pediatric Research 30, 404–412.PubMedCrossRef

Chang, C. H., Nyenhuis, D. L., Cella, D., Luchetta, T., Dineen, K., & Reder, A. T. (2003). Psychometric evaluation of the Chicago Multiscale Depression Inventory in multiple sclerosis patients. Multiple Sclerosis 9, 160–170.PubMedCrossRef

Cherayil, G. D. (1984). Sialic acid and fatty acid concentrations in lymphocytes, red blood cells and plasma from patients with multiple sclerosis. Journal of the Neurological Sciences 63, 1–10.PubMedCrossRef

Crawford, P. B., Obarzanek, E., Morrison, J., & Sabry, Z. I. (1994). Comparative advantage of 3-day food records over 24-hour recall and 5-day food frequency validated by observation of 9- and 10-year-old girls. Journal of the American Dietetic Association 94, 626–630.PubMedCrossRef

Cunnane, S. C, Ho, S., Dore-Duffy, P., Ells, K. R., & Horrobin, D. F. (1989). Essential fatty acid and lipid profiles in plasma and erythroytes in patients with multiple sclerosis. The American Journal of Clinical Nutrition 50, 801–806.PubMed

Dalton E. J., & Heinrichs, R. W. (2005). Depression in multiple sclerosis: A quantitative review of the evidence. Neuropsychology 19, 152–158.PubMedCrossRef

Dodge, J. T., & Phillips, G. B. (1967). Composition of phospholipids and of phospholipids fatty acids and aldehydes in human red cells. Journal of Lipid Research 8, 667–675.PubMed

Edwards, R., Peet, M., Shay, J., & Horrobin, D. (1998). Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. Journal of Affective Disorders 48, 149–155.PubMedCrossRef

Ervin, R. B., Wright, J. D., Wang, C. Y., & Kennedy-Stephenson, J. (2004). Dietary intake of fats and fatty acids for the United States population: 1999–2000. Advance data 8, 1–6.

Farinotti, M., Simi, S., Di Pietrantonj, C., McDowell, N., Brait, L., Lupo, D., et al. (2007). Dietary interventions for multiple sclerosis. Cochrane Database of Systematic Reviews 24, CD004192.

Fisher, M., Johnson, M. H., Natale, A. M., & Levine, P. H. (1987). Linoleic acid levels in white blood cells, platelets, and serum in multiple sclerosis patients. Acta Neurologica Scandinavica 76, 241–245.PubMed

Folch, J., Lees, M., & Sloane Stanley, G. H. (1957). A simple method for the isolation and purification of total lipids from animal tissues. The Journal of Biological Chemistry 226, 497–509.PubMed

Freeman, M. P., Hibbeln, J. R., Davis, J. M., Mischoulon, D., Peet, M., Keck, P. E., et al. (2006). Omega-3 fatty acids: Evidence basis for treatment and future research in psychiatry. Journal of Clinical Psychiatry 67, 1954–1967.PubMed

Garland, M. R, Hallahan, B., McNamara, M., Carney, P. A., Grimes, H., Hibbeln, J. R., et al. (2007). Lipids and essential fatty acids in patients presenting with self-harm. The British Journal of Psychiatry 190, 112–117.PubMedCrossRef

Goulet, J., Nadeau, G., Lapointe, A., Lamarche, B., & Lemieux, S. (2004). Validity and reproducibility of an interview-administered food frequency questionnaire for healthy French–Canadian men and women. Nutrition Journal 3, 13.PubMedCrossRef

Hibbeln, J. R. (1999). Long-chain polyunsaturated fatty acids in depression, related conditions. In M. Peet, I. Glen, & D. F. Horrobin (Eds.), Phospholipid spectrum disorder in psychiatry (pp. 195–210). Carnforth: Marius Press.

Hibbeln, J. R., & Salem, N. (1995). Dietary polyunsaturated fatty acids and depression: When cholesterol does not satisfy. The American Journal of Clinical Nutrition 62, 1–9.PubMed

Holman, R. T., Johnson, S. B., & Kokmen, E. (1989). Deficiencies of polyunsaturated fatty acids and replacement by nonessential fatty acids in plasma lipids in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America 86, 4720–4724.PubMedCrossRef

Horrobin, D. F., & Bennett, C. N. (1999). Depression and bipolar disorder: Relationships to impaired fatty acid and phospholipids metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing, and osteoporosis. Prostaglandins Leukotrienes, and Essential Fatty Acids 60, 217–234.CrossRef

Joffe, R. T., Lippert, G. P., Gray, T. A., Sawa, G., & Horvath, Z. (1987). Mood disorders and multiple sclerosis. Archives of Neurology 44, 376–378.PubMed

Johansson, L. R., Solvoll, K., Bjorneboe, G. E., & Drevon, C. A. (1998). Intake of very-long-chain n-3 fatty acids related to social status and lifestyle. European Journal of Clinical Nutrition 52, 716–721.PubMedCrossRef

Klerman, G. L, & Weisman, N. W. (1989). Increasing rates of depression. JAMA 261, 229–235.CrossRef

Koch, M., Ramsaransing, G. S. M., Fokkena, R., Heersema, D. J., & De Keyser, J. (2006). Erythrocyte membrane fatty acids in benign and progressive forms of multiple sclerosis. Journal of the Neurological Sciences 244, 123–126.PubMedCrossRef

Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 33, 1444–1452.PubMed

Lührmann, P. M., Herbert, B. M., Gaster, C., & Neuhauser-Berthold, M. (1999). Validation of a self-administered dietary record for use in the elderly. European Journal of Nutrition 38, 235–240.PubMedCrossRef

Maes, M., Smith, R., Christophe, A., Cosyns, P., Desnyder, R., & Meltzer, H. Y. (1996). Fatty acid composition in major depression: Decreased ω3 fractions in cholesteryl esters and increased C20:4ω6/C20:5ω3 ration in cholesteryl esters and phospholipids. Journal of Affective Disorders 38, 35–46.PubMedCrossRef

Maes, M., Christophe, A., Delanghe, J., Altamura, C., Neels, H., & Meltzer, H. Y. (1999). Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholestryl esters of depressed patients. Psychiatry Research 85, 275–291.PubMedCrossRef

McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H. P., Lublin, F. D., et al. (2001). Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Scerosis. Annals of Neurology 50, 121–127.PubMedCrossRef

Morrison, W. R., & Smith, L. M. (1964). Preparation of fatty acid methyl esters and dimethylacetals. Journal of Lipid Research 5, 606–608.

Navarro, X., & Segura, R. (1988). Plasma lipids and their fatty acid composition in multiple sclerosis. Acta Neurologica Scandinavica 78, 152–157.PubMedCrossRef

Navarro, X., & Segura, R. (1989). Red blood cell fatty acids in multiple sclerosis. Acta Neurologica Scandinavica 79, 32–37.PubMed

Neu, I. S. (1983). Essential fatty acids in the serum and cerebrospinal fluid of multiple sclerosis patients. Acta Neurologica Scandinavica 67, 151–163.PubMed

Nightingale, S., Woo, E., Smith, A. D., French, J. M., Gale, M. M., Sinclair, H. M., et al. (1990). Red blood cell and adipose tissue fatty acids in mild inactive multiple sclerosis. Acta Neurologica Scandinavica 82, 43–50.PubMedCrossRef

Noonan, C. W., Kathman, S. J., & White, M. C. (2002). Prevalence estimates for MS in the United States and evidence of an increasing trend for women. Neurology 58, 136–138.PubMedCrossRef

Nordvik, I., Myhr, K. M., Nyland, H., & Bjerve, K. S. (2000). Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients. Acta Neurologica Scandinavica 102, 143–149.PubMedCrossRef

Nutrition Coordinating Center (2000). NDS-R food and nutrient database, version 31. Minneapolis: University of Minnesota, [CD-ROM].

Nyenhuis, D. L., Luchetta, T., Yamamoto, C., Terrien, A., Bernardin, L., Rao, S. M., et al. (1998). The development, standardization, and initial validation of the Chicago Multiscale Depression Inventory. Journal of Personality Assessment 70, 386–401.PubMedCrossRef

Okita, M., Yoshida, S., Yamamoto, J., Suzuki, K., Kaneyuki, T., Kubota, M., et al. (1995). n-3 and n-6 fatty acid intake and serum phospholipid fatty acid composition in middle-aged women living in rural and urban areas in Okayama Prefecture. Journal of Nutritional Science and Vitaminology 41, 313–323.PubMed

Okuda, N., Ueshima, H., Okayama, A., Saitoh, S., Nakagawa, H., Rodriguez, B. L., et al. (2005). Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: The INTERLIPID study. Atherosclerosis 178, 371–379.PubMedCrossRef

Parker, G., Gibson, N. A., Brotchie, H., Heruc, G., Rees, A. M., Hadzi-Pavlovic, D. (2006). Omega-3 fatty acids and mood disorders. American Journal of Psychiatry 163, 969–978.PubMedCrossRef

Patten, S. B., & Metz, L. M. (1997). Depression in multiple sclerosis. Psychotherapy and Psychosomatics 66, 286–292.PubMedCrossRef

Peet, M., Murphy, B., Shay, J., & Horrobin, D. (1998). Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biological Psychiatry 43, 315–319.PubMedCrossRef

Rosati, G. (2001). The prevalence of multiple sclerosis in the world: An update. Neurological Sciences 22, 117–139.PubMedCrossRef

Schwartz, S., & Leweling, H. (2005). Multiple sclerosis and nutrition. Multiple Sclerosis 11, 24–32.CrossRef

Sharrack, B., & Hughes, R. A. (1999). The Guys Neurological Disability Scale (GNDS): A new disability measure for multiple sclerosis. Multiple Sclerosis 5, 223–233.PubMed

Šidàk, Z. (1967). Rectangular confidence region for the means of multivariate normal distribution. Journal of the American Statistical Association 62, 626–633.CrossRef

Silvers, K. M., & Scott K. M. (2002). Fish consumption and self-reported physical and mental health status. Public Health Nutrition 5, 427–431.PubMedCrossRef

Smuts, C., Borod, E., Peeples, J., & Carlson, S. E. (2003). High-DHA eggs: Feasibility as a means to enhance circulating DHA in mother and infant. Lipids 38, 407–414.PubMedCrossRef

Swank, R. L., Lerstad, O., Strom, P., & Barker, J. (1952). Multiple sclerosis in rural Norway; its geographic and occupational incidence in relation to nutrition. The New England Journal of Medicine 246, 721–728.CrossRef

Titel: Omega-3 fatty acids and multiple sclerosis: relationship to depression
Auteurs: Robin L. Aupperle
Douglas R. Denney
Sharon G. Lynch
Susan E. Carlson
Debra K. Sullivan
Publicatiedatum: 01-04-2008
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 2/2008
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-007-9139-y

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