Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in:

06-01-2016 | Original Paper

Ocular Fixation Abnormality in Patients with Autism Spectrum Disorder

Auteurs: Aya Shirama, Chieko Kanai, Nobumasa Kato, Makio Kashino

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2016

Abstract

We examined the factors that influence ocular fixation control in adults with autism spectrum disorder (ASD) including sensory information, individuals’ motor characteristics, and inhibitory control. The ASD group showed difficulty in maintaining fixation especially when there was no fixation target. The fixational eye movement characteristics of individuals were consistent regardless of the presence or absence of a fixation target in the controls, but not in the ASD group. Additionally, fixation stability did not correlate with an ability to suppress reflexive saccades measured by an antisaccade task. These findings suggest that ASD adults have deficits in converting alternative sensory information, such as retinal signals in the peripheral visual field or extraretinal signals, to motor commands when the foveal information is unavailable.

vorige artikel Hoarding in Youth with Autism Spectrum Disorders and Anxiety: Incidence, Clinical Correlates, and Behavioral Treatment Response

volgende artikel Clinical Validity of the ADI-R in a US-Based Latino Population

Abel, L. A., Traccis, S., Dell’Osso, L. F., Daroff, R. B., & Troost, B. T. (1984). Square wave oscillation the relationship of saccadic intrusions and oscillations. Neuroophthalmology, 4(1), 21–25. CrossRef

Agam, Y., Joseph, R. M., Barton, J. J., & Manoach, D. S. (2010). Reduced cognitive control of response inhibition by the anterior cingulate cortex in autism spectrum disorders. Neuroimage, 52(1), 336–347. CrossRefPubMedPubMedCentral

American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (DSM-IV-TR). Washington, DC: American Psychiatric Association.

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5). Washington, DC: American Psychiatric Association.

Balslev, D., Himmelbach, M., Karnath, H. O., Borchers, S., & Odoj, B. (2012). Eye proprioception used for visual localization only if in conflict with the oculomotor plan. The Journal of Neuroscience, 32(25), 8569–8573. CrossRefPubMed

Barton, J. J., Pandita, M., Thakkar, K., Goff, D. C., & Manoach, D. S. (2008). The relation between antisaccade errors, fixation stability and prosaccade errors in schizophrenia. Experimental Brain Research, 186(2), 273–282. CrossRefPubMed

Bellebaum, C., Daum, I., Koch, B., Schwarz, M., & Hoffmann, K. P. (2005). The role of the human thalamus in processing corollary discharge. Brain, 128(5), 1139–1154. CrossRefPubMed

Brainard, D. H. (1997). The psychophysics toolbox. Spatial Vision, 10, 433–436. CrossRefPubMed

Cherici, C., Kuang, X., Poletti, M., & Rucci, M. (2012). Precision of sustained fixation in trained and untrained observers. Journal of Vision, 12(6), 31. CrossRefPubMedPubMedCentral

Ciuffreda, K. L., & Tannen, B. (1995). Eye movement basics for the clinician. St. Louis, MO: Mosby-Year book Inc.

Cornsweet, T. N. (1956). Determination of the stimuli for involuntary drifts and saccadic eye movements. Journal of the Optical Society of America, 46(11), 987–993. CrossRefPubMed

Courchesne, E., Saitoh, O., Yeung-Courchesne, R., Press, G. A., Lincoln, A. J., Haas, R. H., & Schreibman, L. (1994). Abnormality of cerebellar vermian lobules VI and VII in patients with infantile autism: identification of hypoplastic and hyperplastic subgroups with MR imaging. American Journal of Roentgenology, 162(1), 123–130. CrossRefPubMed

Courchesne, E., Yeung-Courchesne, R., Hesselink, J. R., & Jernigan, T. L. (1988). Hypoplasia of cerebellar vermal lobules VI and VII in autism. New England Journal of Medicine, 318(21), 1349–1354. CrossRefPubMed

Crapse, T. B., & Sommer, M. A. (2008). Corollary discharge circuits in the primate brain. Current Opinion in Neurobiology, 18(6), 552–557. CrossRefPubMedPubMedCentral

Curtis, C. E., Calkins, M. E., & Iacono, W. G. (2001). Saccadic disinhibition in schizophrenia patients and their first-degree biological relatives. Experimental Brain Research, 137(2), 228–236. CrossRefPubMed

Dell’Osso, L. F., Abel, L. A., & Daroff, R. B. (1977). “Inverse latent” macro square-wave jerks and macro saccadic oscillations. Annals of Neurology, 2, 57–60. CrossRefPubMed

Ditchburn, R. W., & Ginsborg, B. L. (1952). Vision with a stabilized retinal image. Nature, 170, 36–37. CrossRefPubMed

Ditchburn, R. W., & Ginsborg, B. L. (1953). Involuntary eye movements during fixation. Journal of Physiology, 119, 1–17. CrossRefPubMedPubMedCentral

Donaldson, I. M. L. (2000). The functions of the proprioceptors of the eye muscles. Philosophical Transactions of the Royal Society B: Biological Sciences, 355(1404), 1685–1754. CrossRef

Everling, S., & Fischer, B. (1998). The antisaccade: A review of basic research and clinical studies. Neuropsychologia, 36, 885–899. CrossRefPubMed

Fried, M., Tsitsiashvili, E., Bonneh, Y. S., Sterkin, A., Wygnanski-Jaffe, T., Epstein, T., & Polat, U. (2014). ADHD subjects fail to suppress eye blinks and microsaccades while anticipating visual stimuli but recover with medication. Vision Research, 101, 62–72. CrossRefPubMed

Goffart, L., Hafed, Z. M., & Krauzlis, R. J. (2012). Visual fixation as equilibrium: Evidence from superior colliculus inactivation. The Journal of Neuroscience, 32, 10627–10636. CrossRefPubMedPubMedCentral

Guitton, D., Buchtel, H. A., & Douglas, R. M. (1985). Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades. Experimental Brain Research, 58(3), 455–472. CrossRefPubMed

Hall, N. J., & Colby, C. L. (2011). Remapping for visual stability. Philosophical Transactions of the Royal Society of London B: Biological Sciences, 366(1564), 528–539. CrossRefPubMedPubMedCentral

Hanes, D. P., Patterson, W. F., & Schall, J. D. (1998). Role of frontal eye fields in countermanding saccades: Visual, movement, and fixation activity. Journal of Neurophysiology, 79(2), 817–834. PubMed

Hashimoto, T., Tayama, M., Murakawa, K., Yoshimoto, T., Miyazaki, M., Harada, M., & Kuroda, Y. (1995). Development of the brainstem and cerebellum in autistic patients. Journal of autism and developmental disorders, 25(1), 1–18. CrossRefPubMed

Hoddevik, G. H., Brodal, A., Kawamura, K., & Hashikawa, T. (1977). The pontine projection to the cerebellar vermal visual area studied by means of the retrograde axonal transport of horseradish peroxidase. Brain Research, 123(2), 209–227. CrossRefPubMed

Johnson, B. P., Rinehart, N. J., Papadopulos, N., Tonge, B., Millist, L., White, O., & Fielding, J. (2012). A closer look at visually guided saccades in autism and Asperger’s disorder. Frontiers in Integrative Neuroscience, 6, 1–7. CrossRef

Jou, R. J., Frazier, T. W., Keshavan, M. S., Minshew, N. J., & Hardan, A. Y. (2013). A two-year longitudinal pilot MRI study of the brainstem in autism. Behavioural brain research, 251, 163–167. CrossRefPubMedPubMedCentral

Kase, M., Miller, D. C., & Noda, H. (1980). Discharges of Purkinje cells and mossy fibres in the cerebellar vermis of the monkey during saccadic eye movements and fixation. The Journal of Physiology, 300(1), 539–555. CrossRefPubMedPubMedCentral

Kosnik, W., Fikre, J., & Sekuler, R. (1986). Visual fixation stability in older adults. Investigative Ophthalmology and Visual Science, 27(12), 1720–1725. PubMed

Leigh, R. J., & Zee, D. S. (2006). The neurology of eye movements. Oxford: Oxford University Press.

Lewis, R. F., Gaymard, B. M., & Tamargo, R. J. (1998). Efference copy provides the eye position information required for visually guided reaching. Journal of Neurophysiology, 80(3), 1605–1608. PubMed

Luna, B., Doll, S. K., Hegedus, S. J., Minshew, N. J., & Sweeney, J. A. (2007). Maturation of executive function in autism. Biological Psychiatry, 61(4), 474–481. CrossRefPubMed

Martinez-Conde, S., Macknik, S. L., & Troncoso, X. (2004). The role of fixational eye movements in visual perception. Nature Reviews Neuroscience, 5, 229–240. CrossRefPubMed

McDowell, J. E., Brown, G. G., Paulus, M., Martinez, A., Stewart, S. E., Dubowitz, D. J., & Braff, D. L. (2002). Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects. Biological Psychiatry, 51(3), 216–223. CrossRefPubMed

Minshew, N. J., Luna, B., & Sweeney, J. A. (1999). Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism. Neurology, 52(5), 917. CrossRefPubMedPubMedCentral

Munoz, D. P., Armstrong, I. T., Hampton, K. A., & Moore, K. D. (2003). Altered control of visual fixation and saccadic eye movements in attention-deficit hyperactivity disorder. The Journal of Neurophysiology, 90, 503–514. CrossRefPubMed

Munoz, D. P., & Wurtz, R. H. (1993). Fixation cells in monkey superior colliculus I. Characteristics of cell discharge. The Journal of Neurophysiology, 70, 559–575. PubMed

Nair, A., Treiber, J. M., Shukla, D. K., Shih, P., & Müller, R. A. (2013). Impaired thalamocortical connectivity in autism spectrum disorder: A study of functional and anatomical connectivity. Brain, 136(6), 1942–1955. CrossRefPubMedPubMedCentral

Nowinski, C. V., Minshew, N. J., Luna, B., Takarae, Y., & Sweeney, J. A. (2005). Oculomotor studies of cerebellar function in autism. Psychiatry Research, 137, 11–19. CrossRefPubMed

Padmanabhan, A., Garver, K., O’Hearn, K., Nawarawong, N., Liu, R., Minshew, N., et al. (2015). Developmental changes in brain function underlying inhibitory control in autism spectrum disorders. Autism Research, 8(2), 123–135. CrossRefPubMed

Pelli, D. G. (1997). The VideoToolbox software for visual psychophysics: Transforming numbers into movies. Spatial Vision, 10, 437–442. CrossRefPubMed

Peterburs, J., Thürling, M., Rustemeier, M., Göricke, S., Suchan, B., Timmann, D., & Bellebaum, C. (2015). A cerebellar role in performance monitoring–Evidence from EEG and voxel-based morphometry in patients with cerebellar degenerative disease. Neuropsychologia, 68, 139–147. CrossRefPubMed

Reilly, J. L., Lencer, R., Bishop, J. R., Keedy, S., & Sweeney, J. A. (2008). Pharmacological treatment effects on eye movement control. Brain and Cognition, 68(3), 415–435. CrossRefPubMedPubMedCentral

Riggs, L. A., & Ratliff, F. (1952). The effects of counteracting the normal movements of the eye. Journal of the Optical Society of America, 42, 872–873.

Robertson, A. E., & Simmons, D. R. (2013). The relationship between sensory sensitivity and autistic traits in the general population. Journal of Autism and Developmental Disorders, 43(4), 775–784. CrossRefPubMed

Robinson, D. A. (1972). Eye movements evoked by collicular stimulation in the alert monkey. Vision Research, 12, 1795–1808. CrossRefPubMed

Rojas, D. C., Peterson, E., Winterrowd, E., Reite, M. L., Rogers, S. J., & Tregellas, J. R. (2006). Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms. BMC Psychiatry, 6, 56. CrossRefPubMedPubMedCentral

Rose, D. (1999). The historical roots of the theories of local signs and labeled lines. Perception, 28, 675–685. CrossRefPubMed

Schiller, P. H., & Koerner, F. (1971). Discharge characteristics of single units in superior colliculus of alert rhesus monkeys. Journal of Neurophysiology, 34, 920–934. PubMed

Schmitt, L. M., Cook, E. H., Sweeney, J. A., & Mosconi, M. W. (2014). Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem. Molecular Autism, 5(1), 47. CrossRefPubMedPubMedCentral

Sherrington, C. S. (1898). Further note on the sensory nerves of the eye-muscles. Proceedings of the Royal Society of London, 64(402–411), 120–121. CrossRef

Skavenski, A. A. (1972). Inflow as a source of extraretinal eye position information. Vision Research, 12, 221–229. CrossRefPubMed

Snodderly, D. M. (1987). Effects of light and dark environments on macaque and human fixational eye movements. Vision Research, 27, 401–415. CrossRefPubMed

Sommer, M. A., & Wurtz, R. H. (2002). A pathway in primate brain for internal monitoring of movements. Science, 296(5572), 1480–1482. CrossRefPubMed

Stanfield, A. C., McIntosh, A. M., Spencer, M. D., Philip, R., Gaur, S., & Lawrie, S. M. (2008). Towards a neuroanatomy of autism: a systematic review and meta-analysis of structural magnetic resonance imaging studies. European Psychiatry, 23(4), 289–299. CrossRefPubMed

Steinman, R. M. (1965). Effect of target size, luminance, and color on monocular fixation. Journal of Optical Society of America, 55(9), 1158–1164. CrossRef

Takarae, Y., Minshew, N. J., Luna, B., & Sweeney, J. A. (2004). Oculomotor abnormalities parallel cerebellar histopathology in autism. Journal of Neurology, Neurosurgery and Psychiatry, 75(9), 1359–1361. CrossRefPubMedPubMedCentral

Takarae, Y., Minshew, N. J., Luna, B., & Sweeney, J. A. (2007). Atypical involvement of frontostriatal systems during sensorimotor control in autism. Psychiatry Research: Neuroimaging, 156(2), 117–127. CrossRefPubMedPubMedCentral

Takayama, Y., Hashimoto, R., Tani, M., Kanai, C., Yamada, T., Watanabe, H., & Iwanami, A. (2014). Standardization of the Japanese version of the Glasgow sensory questionnaire (GSQ). Research in Autism Spectrum Disorders, 8(4), 347–353. CrossRef

Timberlake, G. T., Sharma, M. K., Grose, S. A., Gobert, D. V., Gauch, J. M., & Meino, J. H. (2005). Retinal location of the preferred retinal locus relative to the fovea in scanning laser ophthalmoscope images. Optometry and Vision Science, 82, 177–185. CrossRefPubMed

Troost, B. T., & Daroff, R. B. (1977). The ocular motor defects in progressive supranuclear palsy. Annals of Neurology, 2(5), 397–403. CrossRefPubMed

von Helmholtz, H. (1866). Handbuch der physiologischenOptik. Dritter Band Trans. by Southall, J.P.C. as Helmholtz’s Treatise on Physiological Optics volume III (1962, New York: Dover).

Wakabayashi, A., Baron-Cohen, S., Wheelwright, S., & Tojo, Y. (2006). The autism-spectrum quotient (AQ) in Japan: A cross-cultural comparison. Journal of Autism and Developmental Disorders, 36, 263–270. CrossRefPubMed

Wolpert, D. M., Miall, R. C., & Kawato, M. (1998). Internal models in the cerebellum. Trends in Cognitive Sciences, 2(9), 338–347. CrossRefPubMed

Zee, D. S., Yee, R. D., Cogan, D. G., Robinson, D. A., & Engel, W. K. (1976). Ocular motor abnormalities in hereditary cerebellar ataxia. Brain, 99, 207–234. CrossRefPubMed

Titel: Ocular Fixation Abnormality in Patients with Autism Spectrum Disorder
Auteurs: Aya Shirama
Chieko Kanai
Nobumasa Kato
Makio Kashino
Publicatiedatum: 06-01-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 5/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-015-2688-y

Bohn Stafleu van Loghum

Tip

Swipe om te navigeren naar een ander artikel

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 5/2016

Otitis Media and Related Complications Among Children with Autism Spectrum Disorders

The “Eye Avoidance” Hypothesis of Autism Face Processing

Do Individuals with High-Functioning Autism Who Speak a Tone Language Show Intonation Deficits?

Clinical Validity of the ADI-R in a US-Based Latino Population

Social Tools And Rules for Teens (The START Program): Program Description and Preliminary Outcomes of an Experiential Socialization Intervention for Adolescents with Autism Spectrum Disorder

Utility of the 3Di Short Version for the Diagnostic Assessment of Autism Spectrum Disorder and Compatibility with DSM-5