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Gepubliceerd in: Journal of Autism and Developmental Disorders 4/2011

01-04-2011 | Original Paper

Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument

Auteurs: Masafumi Harada, Masako M. Taki, Ayumi Nose, Hitoshi Kubo, Kenji Mori, Hiromu Nishitani, Tsuyoshi Matsuda

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2011

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Abstract

Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu.
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Metagegevens
Titel
Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument
Auteurs
Masafumi Harada
Masako M. Taki
Ayumi Nose
Hitoshi Kubo
Kenji Mori
Hiromu Nishitani
Tsuyoshi Matsuda
Publicatiedatum
01-04-2011
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 4/2011
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-010-1065-0