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17-03-2023 | Original Paper

No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children

Auteurs: Seppo P. Ahlfors, Steven Graham, Hari Bharadwaj, Fahimeh Mamashli, Sheraz Khan, Robert M. Joseph, Ainsley Losh, Stephanie Pawlyszyn, Nicole M. McGuiggan, Mark Vangel, Matti S. Hämäläinen, Tal Kenet

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2024

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Abstract

Auditory steady-state response (ASSR) has been studied as a potential biomarker for abnormal auditory sensory processing in autism spectrum disorder (ASD), with mixed results. Motivated by prior somatosensory findings of group differences in inter-trial coherence (ITC) between ASD and typically developing (TD) individuals at twice the steady-state stimulation frequency, we examined ASSR at 25 and 50 as well as 43 and 86 Hz in response to 25-Hz and 43-Hz auditory stimuli, respectively, using magnetoencephalography. Data were recorded from 22 ASD and 31 TD children, ages 6–17 years. ITC measures showed prominent ASSRs at the stimulation and double frequencies, without significant group differences. These results do not support ASSR as a robust ASD biomarker of abnormal auditory processing in ASD. Furthermore, the previously observed atypical double-frequency somatosensory response in ASD did not generalize to the auditory modality. Thus, the hypothesis about modality-independent abnormal local connectivity in ASD was not supported.
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Metagegevens
Titel
No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children
Auteurs
Seppo P. Ahlfors
Steven Graham
Hari Bharadwaj
Fahimeh Mamashli
Sheraz Khan
Robert M. Joseph
Ainsley Losh
Stephanie Pawlyszyn
Nicole M. McGuiggan
Mark Vangel
Matti S. Hämäläinen
Tal Kenet
Publicatiedatum
17-03-2023
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2024
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-023-05907-w