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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2015

01-02-2015 | Original Paper

Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders

Auteurs: J. Christopher Edgar, Sarah Y. Khan, Lisa Blaskey, Vivian Y. Chow, Michael Rey, William Gaetz, Katelyn M. Cannon, Justin F. Monroe, Lauren Cornew, Saba Qasmieh, Song Liu, John P. Welsh, Susan E. Levy, Timothy P. L. Roberts

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2015

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Abstract

Previous studies have observed evoked response latency as well as gamma band superior temporal gyrus (STG) auditory abnormalities in individuals with autism spectrum disorders (ASD). A limitation of these studies is that associations between these two abnormalities, as well as the full extent of oscillatory phenomena in ASD in terms of frequency and time, have not been examined. Subjects were presented pure tones at 200, 300, 500, and 1,000 Hz while magnetoencephalography assessed activity in STG auditory areas in a sample of 105 children with ASD and 36 typically developing controls (TD). Findings revealed a profile such that auditory STG processes in ASD were characterized by pre-stimulus abnormalities across multiple frequencies, then early high-frequency abnormalities followed by low-frequency abnormalities. Increased pre-stimulus activity was a ‘core’ abnormality, with pre-stimulus activity predicting post-stimulus neural abnormalities, group membership, and clinical symptoms (CELF-4 Core Language Index). Deficits in synaptic integration in the auditory cortex are associated with oscillatory abnormalities in ASD as well as patient symptoms. Increased pre-stimulus activity in ASD likely demonstrates a fundamental signal-to-noise deficit in individuals with ASD, with elevations in oscillatory activity suggesting an inability to maintain an appropriate ‘neural tone’ and an inability to rapidly return to a resting state prior to the next stimulus.
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1
Complex demodulation uses a finite impulse response (FIR) low-pass filter with a Gaussian wave shape in the time domain. Complex demodulation is equivalent to a wavelet transformation using Morlet-type wavelets with a fixed time–frequency resolution across frequencies.
 
Literatuur
go back to reference Berg, P., & Scherg, M. (1994). A multiple source approach to the correction of eye artifacts. Electroencephalography and Clinical Neurophysiology, 90(3), 229–241. PubMedCrossRef Berg, P., & Scherg, M. (1994). A multiple source approach to the correction of eye artifacts. Electroencephalography and Clinical Neurophysiology, 90(3), 229–241. PubMedCrossRef
go back to reference Bibbig, A., Traub, R. D., & Whittington, M. A. (2002). Long-range synchronization of gamma and beta oscillations and the plasticity of excitatory and inhibitory synapses: A network model. Journal of Neurophysiology, 88(4), 1634–1654. PubMed Bibbig, A., Traub, R. D., & Whittington, M. A. (2002). Long-range synchronization of gamma and beta oscillations and the plasticity of excitatory and inhibitory synapses: A network model. Journal of Neurophysiology, 88(4), 1634–1654. PubMed
go back to reference Cantor, D. S., Thatcher, R. W., Hrybyk, M., & Kaye, H. (1986). Computerized EEG analyses of autistic children. Journal of Autism and Developmental Disorders, 16(2), 169–187. PubMedCrossRef Cantor, D. S., Thatcher, R. W., Hrybyk, M., & Kaye, H. (1986). Computerized EEG analyses of autistic children. Journal of Autism and Developmental Disorders, 16(2), 169–187. PubMedCrossRef
go back to reference Casanova, M. F., Buxhoeveden, D. P., & Brown, C. (2002). Clinical and macroscopic correlates of minicolumnar pathology in autism. Journal of Child Neurology, 17(9), 692–695. PubMedCrossRef Casanova, M. F., Buxhoeveden, D. P., & Brown, C. (2002). Clinical and macroscopic correlates of minicolumnar pathology in autism. Journal of Child Neurology, 17(9), 692–695. PubMedCrossRef
go back to reference Ehrlichman, R. S., Gandal, M. J., Maxwell, C. R., Lazarewicz, M. T., Finkel, L. H., Contreras, D., et al. (2009). N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia. Neuroscience, 158(2), 705–712. PubMedCrossRef Ehrlichman, R. S., Gandal, M. J., Maxwell, C. R., Lazarewicz, M. T., Finkel, L. H., Contreras, D., et al. (2009). N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia. Neuroscience, 158(2), 705–712. PubMedCrossRef
go back to reference Gage, N. M., Siegel, B., Callen, M., & Roberts, T. P. (2003). Cortical sound processing in children with autism disorder: An MEG investigation. Neuroreport, 14(16), 2047–2051. PubMedCrossRef Gage, N. M., Siegel, B., Callen, M., & Roberts, T. P. (2003). Cortical sound processing in children with autism disorder: An MEG investigation. Neuroreport, 14(16), 2047–2051. PubMedCrossRef
go back to reference Hoechstetter, K., Bornfleth, H., Weckesser, D., Ille, N., Berg, P., & Scherg, M. (2004). BESA source coherence: A new method to study cortical oscillatory coupling. Brain Topography, 16(4), 233–238. PubMedCrossRef Hoechstetter, K., Bornfleth, H., Weckesser, D., Ille, N., Berg, P., & Scherg, M. (2004). BESA source coherence: A new method to study cortical oscillatory coupling. Brain Topography, 16(4), 233–238. PubMedCrossRef
go back to reference Jackson, M. E., Homayoun, H., & Moghaddam, B. (2004). NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America, 101(22), 8467–8472. PubMedCentralPubMedCrossRef Jackson, M. E., Homayoun, H., & Moghaddam, B. (2004). NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America, 101(22), 8467–8472. PubMedCentralPubMedCrossRef
go back to reference Lachaux, J. P., Rodriguez, E., Martinerie, J., & Varela, F. J. (1999). Measuring phase synchrony in brain signals. Human Brain Mapping, 8(4), 194–208. PubMedCrossRef Lachaux, J. P., Rodriguez, E., Martinerie, J., & Varela, F. J. (1999). Measuring phase synchrony in brain signals. Human Brain Mapping, 8(4), 194–208. PubMedCrossRef
go back to reference Leung, L. W. (1985). Spectral analysis of hippocampal EEG in the freely moving rat: Effects of centrally active drugs and relations to evoked potentials. Electroencephalography and Clinical Neurophysiology, 60(1), 65–77. PubMedCrossRef Leung, L. W. (1985). Spectral analysis of hippocampal EEG in the freely moving rat: Effects of centrally active drugs and relations to evoked potentials. Electroencephalography and Clinical Neurophysiology, 60(1), 65–77. PubMedCrossRef
go back to reference Lins, O. G., Picton, T. W., Berg, P., & Scherg, M. (1993). Ocular artifacts in recording EEGs and event-related potentials. II: Source dipoles and source components. Brain Topography, 6(1), 65–78. PubMedCrossRef Lins, O. G., Picton, T. W., Berg, P., & Scherg, M. (1993). Ocular artifacts in recording EEGs and event-related potentials. II: Source dipoles and source components. Brain Topography, 6(1), 65–78. PubMedCrossRef
go back to reference Ma, J., & Leung, L. S. (2000). Relation between hippocampal gamma waves and behavioral disturbances induced by phencyclidine and methamphetamine. Behavioural Brain Research, 111(1–2), 1–11. PubMedCrossRef Ma, J., & Leung, L. S. (2000). Relation between hippocampal gamma waves and behavioral disturbances induced by phencyclidine and methamphetamine. Behavioural Brain Research, 111(1–2), 1–11. PubMedCrossRef
go back to reference Ma, J., & Leung, L. S. (2007). The supramammillo-septal-hippocampal pathway mediates sensorimotor gating impairment and hyperlocomotion induced by MK-801 and ketamine in rats. Psychopharmacology (Berl), 191(4), 961–974. CrossRef Ma, J., & Leung, L. S. (2007). The supramammillo-septal-hippocampal pathway mediates sensorimotor gating impairment and hyperlocomotion induced by MK-801 and ketamine in rats. Psychopharmacology (Berl), 191(4), 961–974. CrossRef
go back to reference Oram Cardy, J. E. (2008). Auditory evoked fields predict language ability and impairment in children. International Journal of Psychophysiology, 68(2), 170–175. PubMedCrossRef Oram Cardy, J. E. (2008). Auditory evoked fields predict language ability and impairment in children. International Journal of Psychophysiology, 68(2), 170–175. PubMedCrossRef
go back to reference Orekhova, E. V., Stroganova, T. A., Nygren, G., Tsetlin, M. M., Posikera, I. N., Gillberg, C., et al. (2007). Excess of high frequency electroencephalogram oscillations in boys with autism. Biological Psychiatry, 62(9), 1022–1029. PubMedCrossRef Orekhova, E. V., Stroganova, T. A., Nygren, G., Tsetlin, M. M., Posikera, I. N., Gillberg, C., et al. (2007). Excess of high frequency electroencephalogram oscillations in boys with autism. Biological Psychiatry, 62(9), 1022–1029. PubMedCrossRef
go back to reference Paetau, R., Ahonen, A., Salonen, O., & Sams, M. (1995). Auditory evoked magnetic fields to tones and pseudowords in healthy children and adults. Journal of Clinical Neurophysiology, 12(2), 177–185. PubMedCrossRef Paetau, R., Ahonen, A., Salonen, O., & Sams, M. (1995). Auditory evoked magnetic fields to tones and pseudowords in healthy children and adults. Journal of Clinical Neurophysiology, 12(2), 177–185. PubMedCrossRef
go back to reference Papp, N., & Ktonas, P. (1977). Critical evaluation of complex demodulation techniques for the quantification of bioelectrical activity. Biomedical Sciences Instrumentation, 13, 135–145. PubMed Papp, N., & Ktonas, P. (1977). Critical evaluation of complex demodulation techniques for the quantification of bioelectrical activity. Biomedical Sciences Instrumentation, 13, 135–145. PubMed
go back to reference Pinault, D. (2008). N-methyl d-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant gamma oscillations in the rat neocortex. Biological Psychiatry, 63(8), 730–735. PubMedCrossRef Pinault, D. (2008). N-methyl d-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant gamma oscillations in the rat neocortex. Biological Psychiatry, 63(8), 730–735. PubMedCrossRef
go back to reference Roberts, T. P., Cannon, K. M., Tavabi, K., Blaskey, L., Khan, S. Y., Monroe, J. F., et al. (2011). Auditory magnetic mismatch field latency: A biomarker for language impairment in Autism. Biological Psychiatry, 70(3), 263–269. doi: 10.​1016/​j.​biopsych.​2011.​01.​015. Roberts, T. P., Cannon, K. M., Tavabi, K., Blaskey, L., Khan, S. Y., Monroe, J. F., et al. (2011). Auditory magnetic mismatch field latency: A biomarker for language impairment in Autism. Biological Psychiatry, 70(3), 263–269. doi: 10.​1016/​j.​biopsych.​2011.​01.​015.
go back to reference Roberts, T. P., Khan, S. Y., Rey, M., Monroe, J. F., Cannon, K., Blaskey, L., et al. (2010). MEG detection of delayed auditory evoked responses in autism spectrum disorders: Towards an imaging biomarker for autism. Autism Research, 3(1), 8–18. doi: 10.​1002/​aur.​111. PubMedCentralPubMed Roberts, T. P., Khan, S. Y., Rey, M., Monroe, J. F., Cannon, K., Blaskey, L., et al. (2010). MEG detection of delayed auditory evoked responses in autism spectrum disorders: Towards an imaging biomarker for autism. Autism Research, 3(1), 8–18. doi: 10.​1002/​aur.​111. PubMedCentralPubMed
go back to reference Roberts, T. P., Schmidt, G. L., Egeth, M., Blaskey, L., Rey, M. M., Edgar, J. C., et al. (2008). Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders. International Journal of Psychophysiology, 68(2), 149–160. PubMedCentralPubMedCrossRef Roberts, T. P., Schmidt, G. L., Egeth, M., Blaskey, L., Rey, M. M., Edgar, J. C., et al. (2008). Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders. International Journal of Psychophysiology, 68(2), 149–160. PubMedCentralPubMedCrossRef
go back to reference Rojas, D. C., Maharajh, K., Teale, P., & Rogers, S. J. (2008). Reduced neural synchronization of gamma-band MEG oscillations in first-degree relatives of children with autism. BMC Psychiatry, 8, 66. PubMedCentralPubMedCrossRef Rojas, D. C., Maharajh, K., Teale, P., & Rogers, S. J. (2008). Reduced neural synchronization of gamma-band MEG oscillations in first-degree relatives of children with autism. BMC Psychiatry, 8, 66. PubMedCentralPubMedCrossRef
go back to reference Rubenstein, J. L., & Merzenich, M. M. (2003). Model of autism: Increased ratio of excitation/inhibition in key neural systems. Genes Brain Behavior, 2(5), 255–267. CrossRef Rubenstein, J. L., & Merzenich, M. M. (2003). Model of autism: Increased ratio of excitation/inhibition in key neural systems. Genes Brain Behavior, 2(5), 255–267. CrossRef
go back to reference Saunders, J. A., Gandal, M. J., Roberts, T. P., & Siegel, S. J. (2012). NMDA antagonist MK801 recreates auditory electrophysiology disruption present in autism and other neurodevelopmental disorders. Behavioural Brain Research, 234(2), 233–237. PubMedCentralPubMedCrossRef Saunders, J. A., Gandal, M. J., Roberts, T. P., & Siegel, S. J. (2012). NMDA antagonist MK801 recreates auditory electrophysiology disruption present in autism and other neurodevelopmental disorders. Behavioural Brain Research, 234(2), 233–237. PubMedCentralPubMedCrossRef
go back to reference Saunders, J. A., Tatard-Leitman V. M., Suh, J., Billingslea, E. N., Roberts, T. P., & Siegel, S. J. (2013). Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes. Autism Research, 6(2), 69–77. doi: 10.​1002/​aur.​1264. Saunders, J. A., Tatard-Leitman V. M., Suh, J., Billingslea, E. N., Roberts, T. P., & Siegel, S. J. (2013). Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes. Autism Research, 6(2), 69–77. doi: 10.​1002/​aur.​1264.
go back to reference Scherg, M., (1990). Fundamentals of dipole source potential analysis, in Auditory evoked magnetic fields and electric potentials. Advances in audiology.In: M.H.G.L.R. Gandori, (eds), Karger: Basel, Switzerland p. 40–69. Scherg, M., (1990). Fundamentals of dipole source potential analysis, in Auditory evoked magnetic fields and electric potentials. Advances in audiology.In: M.H.G.L.R. Gandori, (eds), Karger: Basel, Switzerland p. 40–69.
go back to reference Scherg, M., & Berg, P. (1996). New concepts of brain source imaging and localization. Electroencephalography and Clinical Neurophysiology. Supplement, 46, 127–137. PubMed Scherg, M., & Berg, P. (1996). New concepts of brain source imaging and localization. Electroencephalography and Clinical Neurophysiology. Supplement, 46, 127–137. PubMed
go back to reference Scherg, M., & Ebersole, J. S. (1994). Brain source imaging of focal and multifocal epileptiform EEG activity. Neurophysiologie Clinique, 24(1), 51–60. PubMedCrossRef Scherg, M., & Ebersole, J. S. (1994). Brain source imaging of focal and multifocal epileptiform EEG activity. Neurophysiologie Clinique, 24(1), 51–60. PubMedCrossRef
go back to reference Scherg, M., Ille, N., Bornfleth, H., & Berg, P. (2002). Advanced tools for digital EEG review: Virtual source montages, whole-head mapping, correlation, and phase analysis. Journal of Clinical Neurophysiology, 19(2), 91–112. PubMedCrossRef Scherg, M., Ille, N., Bornfleth, H., & Berg, P. (2002). Advanced tools for digital EEG review: Virtual source montages, whole-head mapping, correlation, and phase analysis. Journal of Clinical Neurophysiology, 19(2), 91–112. PubMedCrossRef
go back to reference Scherg, M., & von Cramon, D. (1985). A new interpretation of the generators of BAEP waves I-V: Results of a spatio-temporal dipole model. Electroencephalography and Clinical Neurophysiology, 62(4), 290–299. PubMedCrossRef Scherg, M., & von Cramon, D. (1985). A new interpretation of the generators of BAEP waves I-V: Results of a spatio-temporal dipole model. Electroencephalography and Clinical Neurophysiology, 62(4), 290–299. PubMedCrossRef
go back to reference Tamas, G., Buhl, E. H., Lorincz, A., & Somogyi, P. (2000). Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons. Nature Neuroscience, 3(4), 366–371. doi: 10.​1038/​73936. PubMedCrossRef Tamas, G., Buhl, E. H., Lorincz, A., & Somogyi, P. (2000). Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons. Nature Neuroscience, 3(4), 366–371. doi: 10.​1038/​73936. PubMedCrossRef
go back to reference Uhlhaas, P. J., & Singer, W. (2007). What do disturbances in neural synchrony tell us about autism? Biological Psychiatry, 62(3), 190–191. PubMedCrossRef Uhlhaas, P. J., & Singer, W. (2007). What do disturbances in neural synchrony tell us about autism? Biological Psychiatry, 62(3), 190–191. PubMedCrossRef
go back to reference Wechsler, D. (2003). Wechsler intelligence scale for children (Vol. 3). San Antonio, TX: The Psychological Corporation. Wechsler, D. (2003). Wechsler intelligence scale for children (Vol. 3). San Antonio, TX: The Psychological Corporation.
go back to reference Whittington, M. A., Traub, R. D., & Jefferys, J. G. (1995). Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation. Nature, 373(6515), 612–615. PubMedCrossRef Whittington, M. A., Traub, R. D., & Jefferys, J. G. (1995). Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation. Nature, 373(6515), 612–615. PubMedCrossRef
go back to reference Whittington, M. A., Traub, R. D., Kopell, N., Ermentrout, B., & Buhl, E. H. (2000). Inhibition-based rhythms: Experimental and mathematical observations on network dynamics. International Journal of Psychophysiology, 38(3), 315–336. PubMedCrossRef Whittington, M. A., Traub, R. D., Kopell, N., Ermentrout, B., & Buhl, E. H. (2000). Inhibition-based rhythms: Experimental and mathematical observations on network dynamics. International Journal of Psychophysiology, 38(3), 315–336. PubMedCrossRef
go back to reference Wilson, T. W., Rojas, D. C., Reite, M. L., Teale, P. D., & Rogers, S. J. (2007). Children and adolescents with autism exhibit reduced MEG steady-state gamma responses. Biological Psychiatry, 62(3), 192–197. PubMedCentralPubMedCrossRef Wilson, T. W., Rojas, D. C., Reite, M. L., Teale, P. D., & Rogers, S. J. (2007). Children and adolescents with autism exhibit reduced MEG steady-state gamma responses. Biological Psychiatry, 62(3), 192–197. PubMedCentralPubMedCrossRef
go back to reference Zvyagintsev, M., Thonnessen, H., Dammers, J., Boers, F., & Mathiak, K. (2008). An automatic procedure for the analysis of electric and magnetic mismatch negativity based on anatomical brain mapping. Journal of Neuroscience Methods, 168(2), 325–333. PubMedCrossRef Zvyagintsev, M., Thonnessen, H., Dammers, J., Boers, F., & Mathiak, K. (2008). An automatic procedure for the analysis of electric and magnetic mismatch negativity based on anatomical brain mapping. Journal of Neuroscience Methods, 168(2), 325–333. PubMedCrossRef
Metagegevens
Titel
Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders
Auteurs
J. Christopher Edgar
Sarah Y. Khan
Lisa Blaskey
Vivian Y. Chow
Michael Rey
William Gaetz
Katelyn M. Cannon
Justin F. Monroe
Lauren Cornew
Saba Qasmieh
Song Liu
John P. Welsh
Susan E. Levy
Timothy P. L. Roberts
Publicatiedatum
01-02-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1904-x