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01-10-2009 | Uitgave 8/2009 Open Access

Quality of Life Research 8/2009

Negative and positive affect are independently associated with patient-reported health status following percutaneous coronary intervention

Quality of Life Research > Uitgave 8/2009
Henneke Versteeg, Susanne S. Pedersen, Ruud A. M. Erdman, Josephine W. I. van Nierop, Peter de Jaegere, Ron T. van Domburg



We examined the association between negative and positive affect and 12-month health status in patients treated with percutaneous coronary intervention (PCI) with drug-eluting stents.


Consecutive PCI patients (n = 562) completed the Global Mood Scale at baseline to assess affect and the EuroQoL-5D (EQ-5D) at baseline and 12-month follow-up to assess health status.


Negative affect [F(1, 522) = 17.14, P < .001] and positive affect [F(1, 522) = 5.11, P = .02] at baseline were independent associates of overall health status at 12-month follow-up, adjusting for demographic and clinical factors. Moreover, there was a significant interaction for negative by positive affect [F(1, 522) = 6.11, P = .01]. In domain-specific analyses, high negative affect was associated with problems in mobility, self-care, usual activities, pain/discomfort, and anxiety/depression with the risk being two to fivefold. Low positive affect was only associated with problems in self-care (OR: 8.14; 95% CI: 1.85–35.9; P = .006) and usual activities (OR: 1.87; 95% CI: 1.17–3.00; P = .009).


Baseline negative and positive affect contribute independently to patient-reported health status 12 months post PCI. Positive affect moderated the detrimental effects of negative affect on overall health status. Enhancing positive affect might be an important target to improve patient-centered outcomes in coronary artery disease.

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