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The online version of this article (doi:10.1007/s10803-013-1899-3) contains supplementary material, which is available to authorized users.
The last two decades have witnessed a surge in research investigating the application of oxytocin as a method of enhancing social behaviour in humans. Preliminary evidence suggests oxytocin may have potential as an intervention for autism. We evaluated a 5-day ‘live-in’ intervention using a double-blind randomized control trial. 38 male youths (7–16 years old) with autism spectrum disorders were administered 24 or 12 international units (depending on weight) intranasal placebo or oxytocin once daily over four consecutive days. The oxytocin or placebo was administered during parent–child interaction training sessions. Parent and child behaviours were assessed using parent reports, clinician ratings, and independent observations, at multiple time points to measure side-effects; social interaction skills; repetitive behaviours; emotion recognition and diagnostic status. Compared to placebo, intranasal oxytocin did not significantly improve emotion recognition, social interaction skills, or general behavioral adjustment in male youths with autism spectrum disorders. The results show that the benefits of nasal oxytocin for young individuals with autism spectrum disorders may be more circumscribed than suggested by previous studies, and suggest caution in recommending it as an intervention that is broadly effective.
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American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text revision): DSM-IV-TR. Washington, DC: American Psychiatric Association.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010). Promoting social behaviour with oxytocin in high-functioning autism spectrum disorders. Proceedings of the National Academy of Science, 107, 4389–4394. CrossRef
Baron-Cohen, S. (2007). Mind reading the interactive guide to emotions. London: Jessica Kingsley Publishers.
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011). Social effects of oxytocin in humans: Context and person matter. Trends in Cognitive Sciences, 15, 301–309. PubMed
Bellini, S., & Akullian, J. (2007). A meta-analysis of video modelling and video self-modeling interventions for children and adolescents with autism spectrum disorders. Council for Exceptional Children, 73, 264–287.
Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000). Varieties of repetitive behavior in autism: Comparisons to mental retardation. Journal of Autism and Development Disorders, 30, 237–243. CrossRef
Bowlby, J., Ainsworth, M., & Bretherton, I. (1992). The origins of attachment theory. Developmental Psychology, 28, 759–775. CrossRef
Campbell, D. B., Datta, D., Jones, S. T., Lee, E. B., Sutcliffe, J. S., Hammock, E. A. D., et al. (2011). Association of oxytocin receptor (OXTR) gene variants with multiply phenotype domains of autism spectrum disorder. Journal of Neurodevelopmental Disorders, 3, 101–112. CrossRefPubMedCentralPubMed
Constantino, J. N., & Gruber, C. P. (2005). Social Responsiveness Scale (SRS) manual. Los Angeles, CA: Western Psychological Services.
Dadds, M. R., Hawes, D., & Merz, S. (2004). The UNSW facial emotion task. Sydney: Department of Psychology, University of New South Wales.
Dawson, G., Berniers, R., & Ring, R. H. (2012). Social attention: a possible early indicator of efficacy in autism clinical trials. Journal of Neurological Disorders, 4(11), 1–12.
Gresham, F. M., & Elliot, S. N. (1990). Social skills rating scale. Circle Pines, MN: American Guidance Service.
Kennedy, H. (2011). What is video interaction guidance (VIG)? In H. Kennedy, M. Lawlor, & L. Todd (Eds.), Video interaction guidance: A relationship-based intervention to promote attunement, empathy and wellbeing. London: Jessica Kingsley Publishers.
MacDonald, E., & Dadds, M. R. (2010). Family observation schedule— Autism spectrum disorders. Unpublished manuscript, University of New South Wales. Available from authors.
Marcus, D. J., & Nelson, C. A. (2001). Neural bases and development of face recognition in autism. CNS Spectrums, 6, 36–59. PubMed
Miller, M., Bales, K. L., Taylor, S. L., Yoon, J., Hostetler, C. M., Carter, C. S., et al. (2013). Oxytocin and vasopressin in children and adolescents with autism spectrum disorders: sex differences and associations with symptoms. Autism Research. February 14. doi: 10.1002/aur.1270.
Novartis Pharmaceuticals. (2009). Novartis Australia health care professionals. Available at http://www.novartis.com.au/products_healthcare.html.
Pasalich, D., & Dadds, M. R. (2009). Family observation schedule VI. Unpublished manuscript, University of New South Wales. Available from authors.
Patterson, G. R. (1982). A social learning approach (vol 3): Coercive family process. Eugene, OR: Castalia Publishing Company.
Schopler, E. C., Reichler, R. J., & Renner, B. R. (1988). The Childhood Autism Rating Scale (CARS). Los Angeles, CA: Western Psychological Services.
Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum: Prevalence, comorbidity and associated factors in a population-derived sample. Journal of the American Academy of Child & Adolescent Psychiatry, 47, 921–929. CrossRef
Tachibana, M., Kagitani-Shimono, K., Mohri, I., Yamamoto, T., Sanefuji, W., Nakamura, A., et al. (2013). Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 23(2), 123–127. doi: 10.1089/cap.2012.0048. CrossRefPubMed
The OSU Research Unit on Paediatric Psychopharmacology. (2005a). OSU Autism Rating Scale-DSM-IV (OARS-4). Columbus, OH: The OSU Research Unit on Paediatric Psychopharmacology.
The OSU Research Unit on Paediatric Psychopharmacology. (2005b). OSU autism CGI. Columbus, OH: The OSU Research Unit on Paediatric Psychopharmacology.
Wechsler, D. (2005). Wechsler Intelligence Scale for children (WISC-IV) (4th ed.). Sydney, Australia: Harcourt Assessment.
- Nasal Oxytocin for Social Deficits in Childhood Autism: A Randomized Controlled Trial
Mark R. Dadds
- Springer US