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Gepubliceerd in: Child Psychiatry & Human Development 2/2019

04-08-2018 | Original Article

N-methyl-d-aspartate Partial Agonist Enhanced Intensive Cognitive-Behavioral Therapy of Panic Disorder in Adolescents

Auteurs: Ovsanna Leyfer, Aubrey Carpenter, Donna Pincus

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 2/2019

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Abstract

Panic disorder (PD) can result in significant functional impairment. Studies of cognitive behavioral therapy (CBT) for PD have demonstrated response rates ranging between 38 and 65%. d-cycloserine (DCS), a partial NMDA agonist, may enhance the effects of exposure-based therapy for PD in adults; however, no studies have examined its effect in adolescents with PD. This study examined the feasibility and acceptability of the use of DCS to augment intensive CBT for PD in adolescents. Twenty-four adolescents (ages 12–17) participated in this randomized, double-blinded, placebo-controlled trial, to compare CBT + DCS to CBT + placebo. The results demonstrated the feasibility and acceptability of the treatment to participants. No significant differences were found between the two groups, but both groups showed significant improvement. This is the first investigation of DCS in the treatment of PD in adolescents and it provides initial support for a more extensive study of DCS augmentation of CBT among adolescents with PD.
Literatuur
1.
go back to reference Barlow DH (2001) Anxiety and its disorders: the nature and treatment of anxiety and panic. Guilford Press, New York Barlow DH (2001) Anxiety and its disorders: the nature and treatment of anxiety and panic. Guilford Press, New York
5.
go back to reference Ollendick T, Pincus D (2008) Panic disorder in adolescents. In: RG Steele, TD Elkin, M Roberts (eds) Handbook of evidence based therapies for children and adolescents. Springer, New York, pp 83–102 CrossRef Ollendick T, Pincus D (2008) Panic disorder in adolescents. In: RG Steele, TD Elkin, M Roberts (eds) Handbook of evidence based therapies for children and adolescents. Springer, New York, pp 83–102 CrossRef
6.
go back to reference Mattis SG, Pincus DB (2003) Treatment of SAD and panic disorder in children and adolescents. In: PM Barrett, TH Ollendick (eds) Handbook of interventions that work with children and adolescents: prevention and treatment. Wiley, West Sussex, pp 145–169 Mattis SG, Pincus DB (2003) Treatment of SAD and panic disorder in children and adolescents. In: PM Barrett, TH Ollendick (eds) Handbook of interventions that work with children and adolescents: prevention and treatment. Wiley, West Sussex, pp 145–169
10.
go back to reference Hendriks G-J, Kampman M, Keijsers GPJ et al (2014) Cognitive-behavioral therapy for panic disorder with agoraphobia in older people: a comparison with younger patients. Depress Anxiety 31:669–677 CrossRefPubMed Hendriks G-J, Kampman M, Keijsers GPJ et al (2014) Cognitive-behavioral therapy for panic disorder with agoraphobia in older people: a comparison with younger patients. Depress Anxiety 31:669–677 CrossRefPubMed
11.
go back to reference Roshanaei-Moghaddam B, Pauly MC, Atkins DC et al (2011) Relative effects of CBT and pharmacotherapy in depression versus anxiety: is medication somewhat better for depression, and CBT somewhat better for anxiety?. Depress Anxiety 28:560–567 CrossRefPubMed Roshanaei-Moghaddam B, Pauly MC, Atkins DC et al (2011) Relative effects of CBT and pharmacotherapy in depression versus anxiety: is medication somewhat better for depression, and CBT somewhat better for anxiety?. Depress Anxiety 28:560–567 CrossRefPubMed
20.
go back to reference Pincus DB, Elkins RM, Hardway C (2014) Intensive treatments for adolescent panic disorder and agoraphobia: helping youth move beyond avoidance. Psychopathol Rev 1:189–194 CrossRef Pincus DB, Elkins RM, Hardway C (2014) Intensive treatments for adolescent panic disorder and agoraphobia: helping youth move beyond avoidance. Psychopathol Rev 1:189–194 CrossRef
22.
go back to reference Norberg MM, Krystal JH, Tolin DF (2008) A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biol Psychiatry 63:1118–1126 CrossRefPubMed Norberg MM, Krystal JH, Tolin DF (2008) A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biol Psychiatry 63:1118–1126 CrossRefPubMed
23.
go back to reference Rodrigues H, Figueira I, Lopes A et al (2014) Does d-cycloserine enhance exposure therapy for anxiety disorders in humans? A meta-analysis. PLoS ONE 9:e93519 CrossRefPubMedPubMedCentral Rodrigues H, Figueira I, Lopes A et al (2014) Does d-cycloserine enhance exposure therapy for anxiety disorders in humans? A meta-analysis. PLoS ONE 9:e93519 CrossRefPubMedPubMedCentral
31.
go back to reference Carpenter-Hyland EP, Chandler LJ (2007) Adaptive plasticity of NMDA receptors and dendritic spines: implications for enhanced vulnerability of the adolescent brain to alcohol addiction. Pharmacol Biochem Behav 86:200–208 CrossRefPubMedPubMedCentral Carpenter-Hyland EP, Chandler LJ (2007) Adaptive plasticity of NMDA receptors and dendritic spines: implications for enhanced vulnerability of the adolescent brain to alcohol addiction. Pharmacol Biochem Behav 86:200–208 CrossRefPubMedPubMedCentral
32.
go back to reference George D, Mallery P, George D, Mallery P (2003) SPSS for Windows step by step: a simple guide and reference. 11.0 update, 4th edn. Allyn & Bacon, Boston George D, Mallery P, George D, Mallery P (2003) SPSS for Windows step by step: a simple guide and reference. 11.0 update, 4th edn. Allyn & Bacon, Boston
33.
go back to reference Silverman W, Albano AM (1996) Anxiety disorders interveiw schedule for DSM-IV. Graywind, New York Silverman W, Albano AM (1996) Anxiety disorders interveiw schedule for DSM-IV. Graywind, New York
38.
go back to reference Hafner RJ, Marks IM (1976) Exposure in vivo of agoraphobics: contributions of diazepam, group exposure, and anxiety evocation. Psychol Med 6:71–88 CrossRefPubMed Hafner RJ, Marks IM (1976) Exposure in vivo of agoraphobics: contributions of diazepam, group exposure, and anxiety evocation. Psychol Med 6:71–88 CrossRefPubMed
44.
go back to reference Guy W (1976) The Clinical Global Impression Scale. In: ECDEU Assessment Manual for Psychopharmacology-Revised. US Dept. of Health, Education & Welfare, ADAMHA, NIMH Psychopharmacology Research Branch, Rockville, MD, pp 218–222 Guy W (1976) The Clinical Global Impression Scale. In: ECDEU Assessment Manual for Psychopharmacology-Revised. US Dept. of Health, Education & Welfare, ADAMHA, NIMH Psychopharmacology Research Branch, Rockville, MD, pp 218–222
45.
go back to reference Mattis SG, Ollendick TH (1997) Panic in children and adolescents: a developmental analysis. Adv Clin Child Psychol 19:74 Mattis SG, Ollendick TH (1997) Panic in children and adolescents: a developmental analysis. Adv Clin Child Psychol 19:74
47.
go back to reference Davis ML, Witcraft SM, Smits JAJ et al (2016) d-cycloserine augmentation of exposure therapy: review and new directions. Qual Prim Care 24 PS:30–32 Davis ML, Witcraft SM, Smits JAJ et al (2016) d-cycloserine augmentation of exposure therapy: review and new directions. Qual Prim Care 24 PS:30–32
50.
go back to reference Hofmann SG (2014) D-cycloserine for treating anxiety disorders: making good exposures better and bad exposures worse. Depress Anxiety 31:175–177 CrossRef Hofmann SG (2014) D-cycloserine for treating anxiety disorders: making good exposures better and bad exposures worse. Depress Anxiety 31:175–177 CrossRef
51.
go back to reference Paul I, Nowak G, Layer RT et al (1994) Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. J Pharmacol Exp Ther 269:95–102 PubMed Paul I, Nowak G, Layer RT et al (1994) Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. J Pharmacol Exp Ther 269:95–102 PubMed
Metagegevens
Titel
N-methyl-d-aspartate Partial Agonist Enhanced Intensive Cognitive-Behavioral Therapy of Panic Disorder in Adolescents
Auteurs
Ovsanna Leyfer
Aubrey Carpenter
Donna Pincus
Publicatiedatum
04-08-2018
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 2/2019
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-018-0837-1

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