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Nicholas B. Allen and Ronald E. Dahl contributed equally to this work.
This commentary discusses the articles in this special section with an emphasis on the specific utility of multivariate, multi-level models in developmental psychopathology for ultimately contributing to both etiologic insights and translational advances. These issues are considered not only in terms of the specific papers, but also within a larger set of questions regarding the opportunities (and challenges) currently facing the field. We describe why we believe this an exciting time for integrative team-science approaches to tackle these challenges—a time that holds great promise for rapid advances in integrative developmental science that includes a biological level of mechanistic understanding. In order to facilitate this, we outline a range of approaches within both translational neuroscience and translational developmental science that can be used as frameworks for understanding how such research can provide etiologic insights regarding real-world targets at the level of social, behavioral, and affective processes that can be modified during key developmental windows of opportunity. We conclude that a “construct validity” framework, where biological data form a critical, but not privileged, component of key etiological mechanisms, combined with a developmental perspective on key period of sensitivity to intervention effects, is most likely to provide significant translational outcomes.
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Clarke, R., Halsey, J., Lewington, S., Lonn, E., Armitage, J., Manson, J. E., & Collins, R. (2010). Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals. Archives of Internal Medicine, 170, 1622–1631. PubMedCrossRef
Cristea, I. A., Mogoașe, C., David, D., & Cuijpers, P. (2015). Practitioner review: cognitive bias modification for mental health problems in children and adolescents: a meta‐analysis. Journal of Child Psychology and Psychiatry.
McArthur, R. A., & Borsini, F. (2008). What do you mean by “Translational research”? An enquiry through animal and translational models for CNS drug discovery: psychiatric disorders. Animal and translational models for CNS drug discovery. Vol 1: Psychiatric disorders.
McCauley, E., Schloredt, K., Gudmundsen, G., Martell, C., & Dimidjian, S. (2011). Expanding behavioral activation to depressed adolescents: lessons learned in treatment development. Cognitive and Behavioral Practice, 18, 371–383. CrossRef
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Spielberg, J. M., Jarcho, J. M., Dahl, R. E., Pine, D. S., Ernst, M., & Nelson, E. E. (2015). Anticipation of peer evaluation in anxious adolescents: divergence in neural activation & maturation. Social Cognitive and Affective Neuroscience. doi: 10.1093/scan/nsu165.
- Multi-Level Models of Internalizing Disorders and Translational Developmental Science: Seeking Etiological Insights that can Inform Early Intervention Strategies
Nicholas B. Allen
Ronald E. Dahl
- Springer US