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31-01-2019 | ORIGINAL PAPER

Mindfulness-Based Stress Reduction with Individuals Who Have Rheumatoid Arthritis: Evaluating Depression and Anxiety as Mediators of Change in Disease Activity

Auteurs: Francesca A. Fogarty, Roger J. Booth, Arier C. Lee, Nicola Dalbeth, Nathan S. Consedine

Gepubliceerd in: Mindfulness | Uitgave 7/2019

Abstract

Although the current randomized controlled trial has previously reported an effect of mindfulness-based stress reduction (MBSR) on improving disease activity in rheumatoid arthritis (RA), the possible mechanisms underlying this relationship remain unknown. This report presents secondary analyses examining anxiety and depression as potential mediators of the effect of MBSR on changes in RA disease activity. Fifty-one RA patients were randomized to either MBSR or to a wait-list control group. Depression and anxiety (Hospital and Anxiety Depression Scale) and RA disease activity (DAS28-CRP) were assessed at baseline (T1), post-treatment (T2), and at two (T3) and four (T4) months’ follow-up. Intention to treat (ITT) and per protocol (PP) analyses using multivariate analyses of variance showed that depression was lower in the MBSR than in the control group, post-treatment and at both follow-up time points. PP analyses suggested that anxiety was lower in the MBSR than in the control group post-treatment. In partial support of expectation, mediation analyses showed that a reduction in depression across the intervention (T2-T1) mediated the effect of MBSR on improvements in RA disease activity at both follow-up time points (T3-T1; T4-T1). This effect held across ITT and PP analyses. PP analyses also suggested an indirect effect of MBSR on RA disease activity via increased anxiety at T3, but not at T4. Together, findings suggest that improvements in depression (rather than anxiety) may mediate the effect of MBSR on RA disease activity. Screening for, and treating depression in RA with MBSR, may have downstream benefits for RA disease activity.

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Alamanos, Y., & Drosos, A. (2005). Epidemiology of adult rheumatoid arthritis. Autoimmunity Reviews, 4(3), 130–136.CrossRefPubMed

Arch, J. J., & Ayers, C. R. (2013). Which treatment worked better for whom? Moderators of group cognitive behavioral therapy versus adapted mindfulness based stress reduction for anxiety disorders. Behaviour Research and Therapy, 51(8), 434–442.CrossRefPubMed

Armijo-Olivo, S., Warren, S., & Magee, D. (2009). Intention to treat analysis, compliance, drop-outs and how to deal with missing data in clinical research: a review. Physical Therapy Reviews, 14(1), 36–49.

Arnett, F. C., Edworthy, S. M., Bloch, D. A., Mcshane, D. J., Fries, J. F., Cooper, N. S., et al. (1988). The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis and Rheumatism, 31(3), 315–324.CrossRefPubMed

Baer, R. A. (2003). Mindfulness training as a clinical intervention: a conceptual and empirical review. Clinical Psychology: Science and Practice, 10, 125–143.

Brown, K., & Ryan, R. (2003). The benefits of being present: mindfulness and its role in psychological well-being. Journal of Personality and Social Psychology, 84, 822-848.CrossRefPubMed

Cordingley, L., Prajapati, R., Plant, D., Maskell, D., Morgan, C., Ali, F. R., et al. (2014). Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis. Arthritis Care and Research, 66, 861–868.CrossRefPubMed

Creswell, J. D. (2016). Mindfulness interventions. Annual Review of Psychology, 68, 491-516.

Creswell, J. D., Pacilio, L. E., Lindsay, E. K., & Brown, K. W. (2014). Brief mindfulness meditation training alters psychological and neuroendocrine responses to social evaluative stress. Psychoneuroendocrinology, 44, 1–12.CrossRefPubMed

Cutolo, M., Kitas, G., & van Riel, P. (2014). Burden of disease in treated rheumatoid arthritis patients: going beyond the joint. Seminars in Arthritis and Rheumatism, 43(4), 479–488.CrossRefPubMed

DiMatteo, M. R., Lepper, H. S., & Croghan, T. W. (2000). Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Archives of Internal Medicine, 160(14), 2101–2107.CrossRefPubMed

Fogarty, F. A., Booth, R. J., Gamble, G. D., Dalbeth, N., & Consedine, N. S. (2015). The effect of mindfulness-based stress reduction on disease activity in people with rheumatoid arthritis: a randomised controlled trial. Annals of the Rheumatic Diseases, 74, 472–474.CrossRefPubMed

Fritz, M. S., & MacKinnon, D. P. (2007). Required sample size to detect the mediated effect. Psychological Science, 18(3), 233–239.CrossRefPubMed

Godha, D., Shi, L., & Mavronicolas, H. (2010). Association between tendency towards depression and severity of rheumatoid arthritis from a national representative sample: the Medical Expenditure Panel Survey. Current Medical Research and Opinion, 26, 1685–1690.CrossRefPubMed

Grossman, P., Niemann, L., Schmidt, S., & Walach, H. (2004). Mindfulness-based stress reduction and health benefits: a meta-analysis. Journal of Psychosomatic Research, 57, 35–43.CrossRefPubMed

Hayes, A. F. (2013). Introduction to mediation, moderation, and conditional process analysis: a regression-based approach. Guilford Press.

Isaacs, J. D., & Ferraccioli, G. (2011). The need for personalised medicine for rheumatoid arthritis. Annals of the Rheumatic Diseases, 70, 4–7.CrossRefPubMed

Kabat-Zinn, J. (1990). Full catastrophe living: using the wisdom of your body and mind to face stress, pain and illness. New York: Bantam Dell.

Kabat-Zinn, J. (2003). Mindfulness-based interventions in context: past, present, and future. Clinical Psychology: Science and Practice, 10, 144–156.

Kazdin, A. E. (2007). Mediators and mechanisms of change in psychotherapy research. Annual Review of Clinical Psychology, 3, 1–27.CrossRefPubMed

Keng, S., Smoski, M., & Robins, C. (2011). Effects of mindfulness on psychological health: a review of empirical studies. Clinical Psychology Review, 31, 1041–1056.CrossRefPubMedPubMedCentral

Lee, T. J., Cameron, L. D., Wünsche, B., & Stevens, C. (2011). A randomized trial of computer-based communications using imagery and text information to alter representations of heart disease risk and motivate protective behaviour. British Journal of Health Psychology, 16(1), 72–91.CrossRefPubMed

Lengacher, C., Johnson-Mallard, V., Post-White, J., Moscoso, M., Jacobsen, P., Klein, T., et al. (2009). Randomized controlled trial of mindfulness-based stress reduction (MBSR) for survivors of breast cancer. Psycho-Oncology, 18, 1261–1272.CrossRefPubMed

Leventhal, H., Diefenbach, M., & Leventhal, E. A. (1992). Illness cognition: using common sense to understand treatment adherence and affect cognition interactions. Cognitive Therapy and Research, 16, 143–163.CrossRef

Lindsay, E. K., & Creswell, J. D. (2017). Mechanisms of mindfulness training: Monitor and Acceptance Theory (MAT). Clinical Psychology Review, 51, 48–59.

Logue, M. B., Thomas, A. M., Barbee, J. G., Hoehn-Saric, R., Maddock, R. J., Schwab, J., et al. (1993). Generalized anxiety disorder patients seek evaluation for cardiological symptoms at the same frequency as patients with panic disorder. Journal of Psychiatric Research, 27(1), 55–59.CrossRefPubMed

Lok, E. Y. C., Mok, C. C., Cheng, C. W., & Cheung, E. F. C. (2010). Prevalence and determinants of psychiatric disorders in patients with rheumatoid arthritis. Psychosomatics, 51, 338–338.e8.CrossRefPubMed

Lubeck, D., Spitz, P., Fries, J., Wolfe, F., Mitchell, D., & Roth, S. (1986). A multicenter study of annual health service utilization and costs in rheumatoid arthritis. Arthritis and Rheumatism, 29, 488–493.CrossRefPubMed

Lundkvist, J., Kastäng, F., & Kobelt, G. (2008). The burden of rheumatoid arthritis and access to treatment: health burden and costs. The European Journal of Health Economics, 8, 49–60.CrossRef

Matcham, F., Rayner, L., Steer, S., & Hotopf, M. (2013). The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis. Rheumatology, 52(12), 2136–2148.CrossRefPubMedPubMedCentral

Matcham, F., Norton, S., Scott, D. L., Steer, S., & Hotopf, M. (2015). Symptoms of depression and anxiety predict treatment response and long-term physical health outcomes in rheumatoid arthritis: secondary analysis of a randomized controlled trial. Rheumatology, 55(2), 268-278.

Merkes, M. (2010). Mindfulness-based stress reduction for people with chronic diseases. Australian Journal of Primary Health, 16(3), 200–210.CrossRefPubMed

Moss-Morris, R., Weinman, J., Petrie, K., Horne, R., Cameron, L., & Buick, D. (2002). The Revised Illness Perception Questionnaire (IPQ-R). Psychology and Health, 17, 1–16.CrossRef

Pennebaker, J. W. (2000). Psychological factors influencing the reporting of physical symptoms. The science of self-report: implications for research and practice. Mahwah, NJ: Erlbaum, 299–315.

Pincus, T., Griffith, J., Pearce, S., & Isenberg, D. (1996). Prevalence of self-reported depression in patients with rheumatoid arthritis. Rheumatology, 35, 879–883.CrossRef

Pradhan, E., Baumgarten, M., Langenberg, P., Handwerger, B., Gilpin, A. K., Magyari, T., et al. (2007). Effect of mindfulness-based stress reduction in rheumatoid arthritis patients. Arthritis Care and Research, 57(7), 1134–1142.CrossRefPubMed

Puhan, M. A., Chandra, D., Mosenifar, Z., Ries, A., Make, B., Hansel, N., et al. (2011). The minimal important difference of exercise tests in severe COPD. European Respiratory Journal, 37(4), 784–790.CrossRefPubMed

Rathbun, A., Reed, G., & Harrold, L. (2013). The temporal relationship between depression and rheumatoid arthritis disease activity, treatment persistence and response: a systematic review. Rheumatology, 52(10), 1785–1794.CrossRefPubMed

Rathbun, A. M., Harrold, L. R., & Reed, G. W. (2015). Temporal effect of depressive symptoms on the longitudinal evolution of rheumatoid arthritis disease activity. Arthritis Care and Research, 67(6), 765–775.CrossRefPubMed

Spitzer, R. L., Kroenke, K., Williams, J. B., & Löwe, B. (2006). A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of Internal Medicine, 166(10), 1092–1097.CrossRefPubMed

Treharne, G. J., Kitas, G. D., Lyons, A. C., & Booth, D. A. (2005). Well-being in rheumatoid arthritis: the effects of disease duration and psychosocial factors. Journal of Health Psychology, 10(3), 457–474.CrossRefPubMed

Unnebrink, K., & Windeler, J. (2001). Intention‐to‐treat: methods for dealing with missing values in clinical trials of progressively deteriorating diseases. Statistics in Medicine, 20(24), 3931–3946.

Urbaniak, G., & Plous, S. (2013). Research randomizer (version 4.0) [computer software]. Retrieved July, 7, 2013.

VanDyke, M. M., Parker, J. C., Smarr, K. L., Hewett, J. E., Johnson, G. E., Slaughter, J. R., et al. (2004). Anxiety in rheumatoid arthritis. Arthritis Care and Research, 51(3), 408–412.CrossRefPubMed

Visvanathan, A., Galloway, J., Matcham, F., Hotopf, M., & Norton, S. (2016). The relationship between anxiety and disease characteristics in patients with rheumatoid arthritis: a cross-sectional observational study. Rheumatology, 55(suppl 1), i87–i88.

Waraich, P., Goldner, E. M., Somers, J. M., & Hsu, L. (2004). Prevalence and incidence studies of mood disorders: a systematic review of the literature. The Canadian Journal of Psychiatry, 49(2), 124–138.CrossRefPubMed

Weinman, J., Petrie, K. J., Moss-Morris, R., & Horne, R. (1996). The illness perception questionnaire: a new method for assessing the cognitive representation of illness. Psychology and Health, 11(3), 431–445.CrossRef

Wells, G., Becker, J., Teng, J., Dougados, M., Schiff, M., Smolen, J., et al. (2009). Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Annals of the Rheumatic Diseases, 68(6), 954–960.CrossRefPubMed

Wittchen, H. U., Kessler, R., Pfister, H., Höfler, M., & Lieb, R. (2000). Why do people with anxiety disorders become depressed? A prospective-longitudinal community study. Acta Psychiatrica Scandinavica, 102(s406), 14–23.CrossRef

Wolitzky-Taylor, K. B., Arch, J. J., Rosenfield, D., & Craske, M. G. (2012). Moderators and non-specific predictors of treatment outcome for anxiety disorders: a comparison of cognitive behavioral therapy to acceptance and commitment therapy. Journal of Consulting and Clinical Psychology, 80(5), 786-799.CrossRefPubMed

Zangi, H. A., Mowinckel, P., Finset, A., Eriksson, L. R., Høystad, T. Ø., Lunde, A. K., et al. (2012). A mindfulness-based group intervention to reduce psychological distress and fatigue in patients with inflammatory rheumatic joint diseases: a randomised controlled trial. Annals of the Rheumatic Diseases, 71, 911–917.CrossRefPubMed

Zautra, A., Davis, M., Reich, J., Nicassario, P., Tennen, H., Finan, P., et al. (2008). Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression. Journal of Consulting and Clinical Psychology, 76(3), 408–421.CrossRefPubMed

Zeidan, F., Gordon, N. S., Merchant, J., & Goolkasian, P. (2010). The effects of brief mindfulness meditation training on experimentally induced pain. The Journal of Pain, 11(3), 199–209.

Zeidan, F., Emerson, N. M., Farris, S. R., Ray, J. N., Jung, Y., McHaffie, J. G., & Coghill, R. C. (2015). Mindfulness meditation-based pain relief employs different neural mechanisms than placebo and sham mindfulness meditation-induced analgesia. Journal of Neuroscience, 35(46), 15307–15325.

Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67(6), 361–370.

Titel: Mindfulness-Based Stress Reduction with Individuals Who Have Rheumatoid Arthritis: Evaluating Depression and Anxiety as Mediators of Change in Disease Activity
Auteurs: Francesca A. Fogarty
Roger J. Booth
Arier C. Lee
Nicola Dalbeth
Nathan S. Consedine
Publicatiedatum: 31-01-2019
Uitgeverij: Springer US
Gepubliceerd in: Mindfulness / Uitgave 7/2019
Print ISSN: 1868-8527
Elektronisch ISSN: 1868-8535
DOI: https://doi.org/10.1007/s12671-018-1090-1

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