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07-05-2021

Mindfulness-based stress reduction for breast cancer survivors (MBSR(BC)): evaluating mediators of psychological and physical outcomes in a large randomized controlled trial

Auteurs: Cecile A. Lengacher, L. Forest Gruss, Kevin E. Kip, Richard R. Reich, Katterine G. Chauca, Manolete S. Moscoso, Anisha Joshi, Sara Tinsley, Budhrani Shani, Lakeshia Cousin, Carly Paterson Khan, Matthew Goodman, Jong Y. Park

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 5/2021

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Abstract

MBSR(BC) is known to have a positive impact on psychological and physical symptoms among breast cancer survivors (BCS). The cognitive mechanisms of “how” MBSR(BC) works was addressed in a recent study that found that there was strong consistent evidence that reduced emotional reactivity is a mediator and moderate consistent evidence that mindfulness, rumination, and worry were mediators. The purpose of this study, as part of a larger R01 trial, was to test whether positive effects achieved from the MBSR(BC) program were mediated through changes in increased mindfulness, decreased fear of breast cancer recurrence, and perceived stress. Female BCS > 21 years diagnosed with Stage 0-III breast cancer were randomly assigned to a 6-week MBSR(BC) or a Usual Care (UC)regimen. Potential mediators of 6- and 12-week outcomes were identified by analysis of covariance (ANCOVA), followed by formal mediational analyses of main effects of MBSR(BC) on 6- and 12-week outcomes, including percentage of total effects explained. Among 322 BCS (167 MBSR(BC) and 155 UC), fear of recurrence and perceived stress, but not mindfulness, mediated reductions in anxiety and fatigue at weeks 6 and 12, partially supporting our hypothesis of cognitive mechanisms of MBSR(BC).

Trial Registration

Registration Number: NCT01177124 http://​www.​ClinicalTrials.​gov
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Metagegevens
Titel
Mindfulness-based stress reduction for breast cancer survivors (MBSR(BC)): evaluating mediators of psychological and physical outcomes in a large randomized controlled trial
Auteurs
Cecile A. Lengacher
L. Forest Gruss
Kevin E. Kip
Richard R. Reich
Katterine G. Chauca
Manolete S. Moscoso
Anisha Joshi
Sara Tinsley
Budhrani Shani
Lakeshia Cousin
Carly Paterson Khan
Matthew Goodman
Jong Y. Park
Publicatiedatum
07-05-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 5/2021
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-021-00214-0