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Journal of Autism and Developmental Disorders

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01-03-2012 | Original Paper

Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism

Auteurs: Stepan Melnyk, George J. Fuchs, Eldon Schulz, Maya Lopez, Stephen G. Kahler, Jill J. Fussell, Jayne Bellando, Oleksandra Pavliv, Shannon Rose, Lisa Seidel, David W. Gaylor, S. Jill James

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2012

Abstract

Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism.

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Titel: Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
Auteurs: Stepan Melnyk
George J. Fuchs
Eldon Schulz
Maya Lopez
Stephen G. Kahler
Jill J. Fussell
Jayne Bellando
Oleksandra Pavliv
Shannon Rose
Lisa Seidel
David W. Gaylor
S. Jill James
Publicatiedatum: 01-03-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 3/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-011-1260-7

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