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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2011

01-02-2011 | ORIGINAL PAPER

Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial

Auteurs: Barry Wright, David Sims, Siobhan Smart, Ahmed Alwazeer, Ben Alderson-Day, Victoria Allgar, Clare Whitton, Heather Tomlinson, Sophie Bennett, Jenni Jardine, Nicola McCaffrey, Charlotte Leyland, Christine Jakeman, Jeremy Miles

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2011

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Abstract

Twenty-two children with autism spectrum disorders who had not responded to supported behaviour management strategies for severe dysomnias entered a double blind, randomised, controlled crossover trial involving 3 months of placebo versus 3 months of melatonin to a maximum dose of 10 mg. 17 children completed the study. There were no significant differences between sleep variables at baseline. Melatonin significantly improved sleep latency (by an average of 47 min) and total sleep (by an average of 52 min) compared to placebo, but not number of night wakenings. The side effect profile was low and not significantly different between the two arms.
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Metagegevens
Titel
Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial
Auteurs
Barry Wright
David Sims
Siobhan Smart
Ahmed Alwazeer
Ben Alderson-Day
Victoria Allgar
Clare Whitton
Heather Tomlinson
Sophie Bennett
Jenni Jardine
Nicola McCaffrey
Charlotte Leyland
Christine Jakeman
Jeremy Miles
Publicatiedatum
01-02-2011
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2011
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-010-1036-5

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