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Journal of Autism and Developmental Disorders

Gepubliceerd in:

28-06-2021 | Original Paper

Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial

Auteurs: Masaharu Hayashi, Kazuo Mishima, Michio Fukumizu, Hiroyuki Takahashi, Yuko Ishikawa, Izumi Hamada, Hideyuki Sugioka, Osamu Yotsuya, Yushiro Yamashita

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2022

Abstract

Robust clinical evidence has not been available for melatonin, a drug commonly administered for treating sleep problems of children with autism spectrum disorder (ASD). In a phase 3 randomized, placebo-controlled clinical trial, we administered 1-mg melatonin (n = 65), 4-mg melatonin (n = 65), or placebo (n = 66) to196 children with ASD once daily before bedtime under adequate sleep hygiene interventions. The primary outcome was sleep onset latency (SOL) assessed with the electronic sleep diary. SOL shortened significantly in the 1- and 4-mg melatonin groups compared to the placebo group (− 22.0, − 28.0, and − 5.0 min, respectively; p < 0.0001 each). This therapeutic regimen of melatonin is a reasonable clinical approach to cope with ASD-emergent difficulties in children with ASD.

vorige artikel The Effect of Mindfulness-Based and Acceptance Commitment Therapy-Based Interventions to Improve the Mental Well-Being Among Parents of Children with Developmental Disabilities: A Systematic Review and Meta-Analysis

volgende artikel Alexithymic But Not Autistic Traits Impair Prosocial Behavior

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Titel: Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial
Auteurs: Masaharu Hayashi
Kazuo Mishima
Michio Fukumizu
Hiroyuki Takahashi
Yuko Ishikawa
Izumi Hamada
Hideyuki Sugioka
Osamu Yotsuya
Yushiro Yamashita
Publicatiedatum: 28-06-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05139-w

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