Skip to main content
Top
Gepubliceerd in:

28-06-2021 | Original Paper

Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial

Auteurs: Masaharu Hayashi, Kazuo Mishima, Michio Fukumizu, Hiroyuki Takahashi, Yuko Ishikawa, Izumi Hamada, Hideyuki Sugioka, Osamu Yotsuya, Yushiro Yamashita

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2022

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Robust clinical evidence has not been available for melatonin, a drug commonly administered for treating sleep problems of children with autism spectrum disorder (ASD). In a phase 3 randomized, placebo-controlled clinical trial, we administered 1-mg melatonin (n = 65), 4-mg melatonin (n = 65), or placebo (n = 66) to196 children with ASD once daily before bedtime under adequate sleep hygiene interventions. The primary outcome was sleep onset latency (SOL) assessed with the electronic sleep diary. SOL shortened significantly in the 1- and 4-mg melatonin groups compared to the placebo group (− 22.0, − 28.0, and − 5.0 min, respectively; p < 0.0001 each). This therapeutic regimen of melatonin is a reasonable clinical approach to cope with ASD-emergent difficulties in children with ASD.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference Aman, M. G., & Singh, N. (1994). Aberrant behavior checklist—community. Slosson Educational Publishing Inc. Aman, M. G., & Singh, N. (1994). Aberrant behavior checklist—community. Slosson Educational Publishing Inc.
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Association. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Association.
go back to reference Ballester, P., Martínez, M. J., Javaloyes, A., Inda, M. D., Fernández, N., Gázquez, P., Aguilar, V., Pérez, A., Hernández, L., Richdale, A. L., & Peiró, A. M. (2019). Sleep problems in adults with autism spectrum disorder and intellectual disability. Autism Research, 12(1), 66–79. https://doi.org/10.1002/aur.2000CrossRefPubMed Ballester, P., Martínez, M. J., Javaloyes, A., Inda, M. D., Fernández, N., Gázquez, P., Aguilar, V., Pérez, A., Hernández, L., Richdale, A. L., & Peiró, A. M. (2019). Sleep problems in adults with autism spectrum disorder and intellectual disability. Autism Research, 12(1), 66–79. https://​doi.​org/​10.​1002/​aur.​2000CrossRefPubMed
go back to reference Deliens, G., & Peigneux, P. (2019). Sleep-behaviour relationship in children with autism spectrum disorder: Methodological pitfalls and insights from cognition and sensory processing. Developmental Medicine & Child Neurology, 61(12), 1368–1376. https://doi.org/10.1111/dmcn.14235CrossRef Deliens, G., & Peigneux, P. (2019). Sleep-behaviour relationship in children with autism spectrum disorder: Methodological pitfalls and insights from cognition and sensory processing. Developmental Medicine & Child Neurology, 61(12), 1368–1376. https://​doi.​org/​10.​1111/​dmcn.​14235CrossRef
go back to reference Maenner, M. J., Shaw, K. A., Baio, J., Washington, A., Patrick, M., DiRienzo, M., Christensen, D. L., Wiggins, L. D., Pettygrove, S., Andrews, J. G., Lopez, M., Hudson, A., Baroud, T., Schwenk, Y., White, T., Rosenberg, C. R., Lee, L., Harrington, R. A., Huston, M., … Dietz, P. M. (2020). Prevalence of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network 11 sites, United States, 2016. MMWR Surveill Summ, 69(4), 1–12. https://doi.org/10.15585/mmwr.ss6904a1CrossRefPubMedPubMedCentral Maenner, M. J., Shaw, K. A., Baio, J., Washington, A., Patrick, M., DiRienzo, M., Christensen, D. L., Wiggins, L. D., Pettygrove, S., Andrews, J. G., Lopez, M., Hudson, A., Baroud, T., Schwenk, Y., White, T., Rosenberg, C. R., Lee, L., Harrington, R. A., Huston, M., … Dietz, P. M. (2020). Prevalence of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network 11 sites, United States, 2016. MMWR Surveill Summ, 69(4), 1–12. https://​doi.​org/​10.​15585/​mmwr.​ss6904a1CrossRefPubMedPubMedCentral
go back to reference Malow, B., Adkins, K. W., McGrew, S. G., Wang, L., Goldman, S. E., Fawkes, D., & Burnette, C. (2012). Melatonin for sleep in children with autism: A controlled trial examining dose, tolerability, and outcomes. Journal of Autism & Developmental Disorders, 42(8), 1729–1737. https://doi.org/10.1007/s10803-011-1418-3CrossRef Malow, B., Adkins, K. W., McGrew, S. G., Wang, L., Goldman, S. E., Fawkes, D., & Burnette, C. (2012). Melatonin for sleep in children with autism: A controlled trial examining dose, tolerability, and outcomes. Journal of Autism & Developmental Disorders, 42(8), 1729–1737. https://​doi.​org/​10.​1007/​s10803-011-1418-3CrossRef
go back to reference Rigney, G., Ali, N. S., Corkum, P. V., Brown, C. A., Constantin, E., Godbout, R., Hanlon-Dearman, A., Ipsiroglu, O., Reid, G. J., Shea, S., & Smith, I. M. (2018). A systematic review to explore the feasibility of a behavioural sleep intervention for insomnia in children with neurodevelopmental disorders: A transdiagnostic approach. Sleep Medicine Reviews, 41, 244–254. https://doi.org/10.1016/j.smrv.2018.03.008CrossRefPubMed Rigney, G., Ali, N. S., Corkum, P. V., Brown, C. A., Constantin, E., Godbout, R., Hanlon-Dearman, A., Ipsiroglu, O., Reid, G. J., Shea, S., & Smith, I. M. (2018). A systematic review to explore the feasibility of a behavioural sleep intervention for insomnia in children with neurodevelopmental disorders: A transdiagnostic approach. Sleep Medicine Reviews, 41, 244–254. https://​doi.​org/​10.​1016/​j.​smrv.​2018.​03.​008CrossRefPubMed
go back to reference Veatch, O. J., Goldman, S. E., Adkins, K. W., & Malow, B. A. (2015). Melatonin in children with autism spectrum disorders: How does the evidence fit together? Journal of Natural Sciences, 1(7), e125. Veatch, O. J., Goldman, S. E., Adkins, K. W., & Malow, B. A. (2015). Melatonin in children with autism spectrum disorders: How does the evidence fit together? Journal of Natural Sciences, 1(7), e125.
go back to reference Waldhauser, F., Weiszenbacher, G., Tatzer, E., Gisinger, B., Waldhauser, M., Schemper, M., & Frisch, H. (1988). Alterations in nocturnal serum melatonin levels in humans with growth and aging. Journal of Clinical Endocrinology & Metabolism, 66(3), 648–652. https://doi.org/10.1210/jcem-66-3-648CrossRef Waldhauser, F., Weiszenbacher, G., Tatzer, E., Gisinger, B., Waldhauser, M., Schemper, M., & Frisch, H. (1988). Alterations in nocturnal serum melatonin levels in humans with growth and aging. Journal of Clinical Endocrinology & Metabolism, 66(3), 648–652. https://​doi.​org/​10.​1210/​jcem-66-3-648CrossRef
go back to reference Wright, B., Sims, D., Smart, S., Alwazeer, A., Alderson-Day, B., Allgar, V., Whitton, C., Tomlinson, H., Bennett, S., Jardine, J., McCaffrey, N., Leyland, C., Jakeman, C., & Miles, J. (2011). Melatonin versus placebo in children with autism spectrum conditions and severe sleep problems not amenable to behaviour management strategies: A randomised controlled crossover trial. Journal of Autism & Developmental Disorders, 41(2), 175–184. https://doi.org/10.1007/s10803-010-1036-5CrossRef Wright, B., Sims, D., Smart, S., Alwazeer, A., Alderson-Day, B., Allgar, V., Whitton, C., Tomlinson, H., Bennett, S., Jardine, J., McCaffrey, N., Leyland, C., Jakeman, C., & Miles, J. (2011). Melatonin versus placebo in children with autism spectrum conditions and severe sleep problems not amenable to behaviour management strategies: A randomised controlled crossover trial. Journal of Autism & Developmental Disorders, 41(2), 175–184. https://​doi.​org/​10.​1007/​s10803-010-1036-5CrossRef
Metagegevens
Titel
Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial
Auteurs
Masaharu Hayashi
Kazuo Mishima
Michio Fukumizu
Hiroyuki Takahashi
Yuko Ishikawa
Izumi Hamada
Hideyuki Sugioka
Osamu Yotsuya
Yushiro Yamashita
Publicatiedatum
28-06-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-05139-w

Andere artikelen Uitgave 6/2022

Journal of Autism and Developmental Disorders 6/2022 Naar de uitgave