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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-10-2014 | Original Paper

Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep

Auteurs: Suzanne E. Goldman, Karen W. Adkins, M. Wade Calcutt, Melissa D. Carter, Robert L. Goodpaster, Lily Wang, Yaping Shi, Helen J. Burgess, David L. Hachey, Beth A. Malow

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2014

Abstract

Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (C _max) and time to peak concentration (T _max) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin.

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Titel: Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep
Auteurs: Suzanne E. Goldman
Karen W. Adkins
M. Wade Calcutt
Melissa D. Carter
Robert L. Goodpaster
Lily Wang
Yaping Shi
Helen J. Burgess
David L. Hachey
Beth A. Malow
Publicatiedatum: 01-10-2014
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-014-2123-9

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