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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-08-2012 | Original paper

Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes

Auteurs: Beth Malow, Karen W. Adkins, Susan G. McGrew, Lily Wang, Suzanne E. Goldman, Diane Fawkes, Courtney Burnette

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2012

Abstract

Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose–response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population.

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Abidin, R. R. (1995). Parenting stress index (3rd ed.). Odessa, FL: Psychological Assessment Resources.

Achenbach, T. M., & Rescorla, L. A. (2001a). Manual for the ASEBA preschool forms and profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, and Families.

Achenbach, T. M., & Rescorla, L. A. (2001b). Manual for the ASEBA school age forms and profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, and Families.

Adkins, K. W., Goldman, S.E., Fawkes, D., Surdyka, K., Wang, L., & Song, Y. et al. (in press). A pilot study of shoulder placement for actigraphy in children. Behavioral Sleep Medicine.

American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, 4th edn, Text Revision. Washington DC: American Psychiatric Association.

Andersen, I. M., Kaczmarska, J., McGrew, S. G., & Malow, B. A. (2008). Melatonin for insomnia in children with autism spectrum disorders. Journal of Child Neurology, 23(5), 482–485.PubMedCrossRef

Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000). Varieties of repetitive behavior in autism: Comparisons to mental retardation. Journal of Autism and Developmental Disorders, 30(3), 237–243.PubMedCrossRef

Carpay, J. A., Arts, W. F. M., Vermeulen, J., Stroink, H., Brouwer, O. F., Peters, A. C. B., et al. (1996). Parent-completed scales for measuring seizure severity and severity of side-effects on antiepileptic drugs in childhood epilepsy: Development and psychometric analysis. Epilepsy Research, 24, 173–181.PubMedCrossRef

Chervin, R. D., Ruzicka, D. L., Giordani, B. J., et al. (2006). Sleep-disordered breathing, behavior, and cognition in children before and after adenotonsillectomy. Pediatrics, 117, 769–778.CrossRef

Couturier, J. L., Speechley, K. N., Steele, M., Norman, R., Stringer, B., Nicholson, R., et al. (2005). Parental perception of sleep problems in children of normal intelligence with pervasive developmental disorders: Prevalence, severity, and pattern. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 815–822.PubMedCrossRef

Doyen, C., Mighiu, D., Kaye, K., Colineaux, C., Beaumanior, C., Mauraeff, Y., et al. (2011). Melatonin in children with autistic spectrum disorders: Recent and practical data. European Child and Adolescent Psychiatry, 20, 231–239.PubMedCrossRef

Dunn, L. M. (1997). Peabody picture vocabulary test (3rd ed.). Minneapolis, MN: American Guidance Service.

Gabriels, R. L., Cuccaro, M. L., Hill, D. E., Ivers, B. J., & Goldson, E. (2005). Repetitive behaviors in autism: Relationships with associated clinical features. Research on Developmental Disabilities, 26, 169–181.CrossRef

Goldman, S. E., Mc Grew, S., Johnson, K. P., Richdale, A. L., Clemons, T., & Malow, B. A. (2011a). Sleep is associated with problem behaviors in children and adolescents with autism spectrum disorders. Research in Autism Spectrum Disorders, 5, 1223–1229.CrossRef

Goldman S. E., Richdale A. L., Clemons T., & Malow B. A. (2011b). Sleep behaviors in autism spectrum disorders—variations in age from early childhood through adolescence. Journal of Autism and Developmental Disorders, May 3 (epub ahead of print).

Goldman, S. E., Surdyka, K., Cuevas, R., Adkins, K., Wang, L., Malow, B. A., et al. (2009). Defining the sleep phenotype in children with autism. Developmental Neuropsychology, 34, 560–573.PubMedCrossRef

Goodlin-Jones, B. L., Sitnick, S. L., & Tang, K. (2008). The children’s sleep habits questionnaire in toddlers and preschool children. Journal of Developmental and Behavioral Pediatrics, 29, 82–88.PubMedCrossRef

Guénolé, F., Godbout, R., Nicolas, A., Franco, P., Claustrat, B., & Baleyte, J. M. (2011). Melatonin for disordered sleep in individuals with autism spectrum disorders: Systematic review and discussion. Sleep Medicine Reviews, 15(6), 379–387.PubMedCrossRef

Harrington, J. W., Rosen, L., & Garnecho, A. (2006). Parental perceptions and use of complementary and alternative medicine practices for children with autism spectrum disorders in private practice. Journal of Developmental and Behavioral Pediatrics, 27(2 Suppl), S156–S161.PubMedCrossRef

Hollingshead, A. B. (1975). Four factor index of social status. New Haven, CT: Yale University, Department of Sociology.

Hollway, J. A., & Aman, M. G. (2011). Sleep correlates of pervasive developmental disorders: A review of the literature. Research in Developmental Disabilities. doi:10.1016/j.ridd.2011.04.001.

Kaufman, A. S., & Kaufman, N. L. (2004). Kaufman brief intelligence test (2nd ed.). Circle Press, MN: American Guidance Service, Inc.

Krakowiak, P., Goodlin-Jones, B., Hertz-Picciotto, I., Croen, L. A., & Hansen, R. L. (2008). Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: A population-based study. Journal of Sleep Research, 17, 197–206.PubMedCrossRef

Kushida, C. A., Chang, A., Gadkary, C., Guilleminault, C., Carrillo, O., Dement, W. C., et al. (2001). Comparison of actigraphic, polysomnographic, and subjective assessment of sleep parameters in sleep-disordered patients. Sleep Medicine, 2, 389–396.PubMedCrossRef

Lam, K. S. L., & Aman, M. G. (2007). The repetitive behavior scale-revised: Independent validation in individuals with autism spectrum disorders. Journal of Autism Developmental Disorders, 37(5), 855–866.CrossRef

Lichstein, K. L., Stone, K. C., Donaldson, J., Nau, S. D., Soeffing, J. P., Murray, D., et al. (2006). Actigraphy validation with insomnia. Sleep, 29, 232–239.PubMed

Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism Developmental Disorders, 30(3), 205–223.CrossRef

Malow, B. A., Marzec, M. L., McGrew, S. G., Wang, L., & Stone, W. (2006). Characterizing sleep in children with autism spectrum disorders: A multidimensional approach. Sleep, 29, 1563–1571.PubMed

Mayes, S. D., & Calhoun, S. (2009). Variables related to sleep problems in children with autism. Research in Autism Spectrum Disorder, 3, 931–941.CrossRef

Mezick, E. J., Matthews, K. A., Hall, M., Kamarck, T. W., Buysse, D. J., Owens, J. F., et al. (2009). Intra-individual variability in sleep duration and fragmentation: Associations with stress. Psychoneuroendocrinology, 34, 1346–1354.PubMedCrossRef

Mirenda, R., Smith, I. M., & Vaillancourt, T. (2010). Validating the repetitive behavior scale-revised in young children with autism spectrum disorder. Journal of Autism Developmental Disorders, 40, 1521–1530.CrossRef

Owens, J. A., Spirito, A., & McGuinn, M. (2000). The children’s sleep habits questionnaire (CSHQ): Psychometric properties of a survey instrument for school-aged children. Sleep, 23, 1043–1051.PubMed

Phillips Respironics. Actiware/Actiware-ct (2010). Actiwatch communication and sleep analysis software instruction manual. Software Version 5.9.

Reed, H. E., McGrew, S. G., Artibee, K., Surdyka, K., Goldman, S. E., & Frank, K. (2009). Parent-based sleep education workshops in autism. Journal of Child Neurology, 24, 236–245.CrossRef

Richdale, A. L., & Schreck, K. A. (2009). Sleep problems in autism spectrum disorders: Prevalence, nature, & possible biopsychosocial aetiologies. Sleep Medicine Reviews, 13(6), 403–411.PubMedCrossRef

Rossignol, D., & Frye, R. (2011). Melatonin in autism spectrum disorders: A systemic review and meta-analysis. Developmental Medicine and Child Neurology, 53(9), 783–792.PubMedCrossRef

Schreck, K. A., Mulick, J. A., & Smith, A. F. (2004). Sleep problems as possible predictors of intensified symptoms of autism. Research Developmental Disabilities, 25, 57–66.CrossRef

Souders, M. C., Mason, T. B., Valladares, O., Bucan, M., Levy, S. A., Mandell, D. S., et al. (2009). Sleep behaviors and sleep quality in children with autism spectrum disorders. Sleep, 32, 1566–1578.PubMed

Westfall, P., Tobias, R. D., Ron, D., Wolfinger, R. D., & Hochberg, Y. (1999). Multiple comparisons and multiple tests using SAS. Cary, NC: SAS Institute Inc.

Titel: Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes
Auteurs: Beth Malow
Karen W. Adkins
Susan G. McGrew
Lily Wang
Suzanne E. Goldman
Diane Fawkes
Courtney Burnette
Publicatiedatum: 01-08-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-011-1418-3

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