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01-08-2012 | Original paper | Uitgave 8/2012

Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 8/2012

Auteurs:: Beth Malow, Karen W. Adkins, Susan G. McGrew, Lily Wang, Suzanne E. Goldman, Diane Fawkes, Courtney Burnette

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Dr. Burnette has moved to University of New Mexico subsequent to the time of study.

An erratum to this article can be found at http://dx.doi.org/10.1007/s10803-012-1507-y.

Abstract

Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose–response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population.

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Titel: Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes
Auteurs:: Beth Malow
Karen W. Adkins
Susan G. McGrew
Lily Wang
Suzanne E. Goldman
Diane Fawkes
Courtney Burnette
Publicatiedatum: 01-08-2012
DOI: https://doi.org/10.1007/s10803-011-1418-3
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 8/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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