Skip to main content
Top

2021 | OriginalPaper | Hoofdstuk

2. Medische diagnostiek

Auteurs : Robert Damstra, PhD, MD, Kristiana Gordon, PhD, MD, Malou van Zanten, PhD, PT, Sahar Mansour, PhD, MD, Kirsten van Duinen, MD, Sarah Thomis, MSc, Nele Devoogdt, PhD, PT, Inge Fourneau, PhD, MD, Sjan Lavrijsen, PhD, MD, Wendemagegn Enbiale, MD, Michette de Rooij, PhD, MD

Gepubliceerd in: Oedeem en oedeemtherapie

Uitgeverij: Bohn Stafleu van Loghum

share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Samenvatting

Medische diagnostiek vormt de basis voor de analyse van zwelling. Er wordt veel aandacht besteed aan de aspecten rond secundair lymfoedeem, mede in relatie met het uitlokkend moment, zoals een oncologische behandeling, filariasis, podoconiosis, erysipelas of overgewicht. Ook wordt besproken dat primair lymfoedeem geen diagnose is en de oude (tijdsgebonden) indeling in congenitaal, precox en tarda wordt verlaten. Middels een speciaal algoritme wordt de work-up bij verdenking van aangeboren lymfoedeem/vasculaire malformatie gepresenteerd waarbij de verschillende genetische afwijkingen worden doorgenomen. Zorgvuldige feno- en genotypering zijn hierbij essentieel. Ook kan zwelling door een veneuze pathologie worden verklaard. Door een systematische benadering van anamnese, lichamelijk en aanvullend onderzoek krijgt u een helder en praktisch beeld van de medische diagnostiek van zwelling. Er is een speciaal hoofdstuk voor huidafwijkingen bij en door lymfoedeem. Het hele hoofdstuk is rijk geïllustreerd met fotomateriaal.
Literatuur
6.
go back to reference International Society of L. The diagnosis and treatment of peripheral lymphedema: 2013 Consensus Document of the International Society of Lymphology. Lymphology 2013;46(1):1–11 [published Online First: 2013/08/13]. International Society of L. The diagnosis and treatment of peripheral lymphedema: 2013 Consensus Document of the International Society of Lymphology. Lymphology 2013;46(1):1–11 [published Online First: 2013/08/13].
8.
go back to reference Bertsch T, Erbacher G, Corda D, et al. European best practice of lipedema. European Best Practice of Lipedema. Phlebologie. 2020. Bertsch T, Erbacher G, Corda D, et al. European best practice of lipedema. European Best Practice of Lipedema. Phlebologie. 2020.
9.
go back to reference Gloviczki P, Driscoll DJ. Klippel-Trenaunay syndrome: current management. Phlebology. 2007;22(6):291–8. Gloviczki P, Driscoll DJ. Klippel-Trenaunay syndrome: current management. Phlebology. 2007;22(6):291–8.
18.
go back to reference Huang Q, Ge BJ, Liu LM, et al. Successful management of chylous ascites with total parenteral nutrition, somatostatin, and fibrin glue. Chin Med J (Engl). 2007;120(20):1847–9 [published Online First: 2007/11/22]. Huang Q, Ge BJ, Liu LM, et al. Successful management of chylous ascites with total parenteral nutrition, somatostatin, and fibrin glue. Chin Med J (Engl). 2007;120(20):1847–9 [published Online First: 2007/11/22].
21.
22.
go back to reference Connell FC, Gordon K, Brice G, et al. The classification and diagnostic algorithm for primary lymphatic dysplasia: an update from 2010 to include molecular findings. Clin Genet. 2013;84(4):303–14. https://doi.org/10.1111/cge.12173 [published Online First: 2013/04/30]. Connell FC, Gordon K, Brice G, et al. The classification and diagnostic algorithm for primary lymphatic dysplasia: an update from 2010 to include molecular findings. Clin Genet. 2013;84(4):303–14. https://​doi.​org/​10.​1111/​cge.​12173 [published Online First: 2013/04/30].
27.
go back to reference Jones GE, Ostergaard P, Moore AT, et al. Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR): review of phenotype associated with KIF11 mutations. Eur J Hum Genet. 2014;22(7):881–7. https://doi.org/10.1038/ejhg.2013.263 [published Online First: 2013/11/28]. Jones GE, Ostergaard P, Moore AT, et al. Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR): review of phenotype associated with KIF11 mutations. Eur J Hum Genet. 2014;22(7):881–7. https://​doi.​org/​10.​1038/​ejhg.​2013.​263 [published Online First: 2013/11/28].
28.
go back to reference Fotiou E, Martin-Almedina S, Simpson MA, et al. Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. Nat Commun. 2015;6:8085. https://doi.org/10.1038/ncomms9085 [published Online First: 2015/09/04]. Fotiou E, Martin-Almedina S, Simpson MA, et al. Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. Nat Commun. 2015;6:8085. https://​doi.​org/​10.​1038/​ncomms9085 [published Online First: 2015/09/04].
29.
go back to reference Martin-Almedina S, Martinez-Corral I, Holdhus R, et al. EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. J Clin Invest. 2016;126(8):3080–8. https://doi.org/10.1172/jci85794 [published Online First: 2016/07/12]. Martin-Almedina S, Martinez-Corral I, Holdhus R, et al. EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. J Clin Invest. 2016;126(8):3080–8. https://​doi.​org/​10.​1172/​jci85794 [published Online First: 2016/07/12].
30.
go back to reference Brice GW, Mansour S, Ostergaard P, et al. Milroy Disease. 2014. Brice GW, Mansour S, Ostergaard P, et al. Milroy Disease. 2014.
31.
go back to reference Irrthum A, Karkkainen MJ, Devriendt K, et al. Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase. Am J Hum Genet. 2000;67(2):295–301. https://doi.org/10.1086/303019 [published Online First: 2000/06/17]. Irrthum A, Karkkainen MJ, Devriendt K, et al. Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase. Am J Hum Genet. 2000;67(2):295–301. https://​doi.​org/​10.​1086/​303019 [published Online First: 2000/06/17].
32.
go back to reference Gordon K, Schulte D, Brice G, et al. Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema. Circ Res. 2013;112(6):956–60. https://doi.org/10.1161/circresaha.113.300350 [published Online First: 2013/02/16]. Gordon K, Schulte D, Brice G, et al. Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema. Circ Res. 2013;112(6):956–60. https://​doi.​org/​10.​1161/​circresaha.​113.​300350 [published Online First: 2013/02/16].
33.
go back to reference Brice G, Mansour S, Bell R, et al. Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24. J Med Genet. 2002;39(7):478–83. https://doi.org/10.1136/jmg.39.7.478 [published Online First: 2002/07/13]. Brice G, Mansour S, Bell R, et al. Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24. J Med Genet. 2002;39(7):478–83. https://​doi.​org/​10.​1136/​jmg.​39.​7.​478 [published Online First: 2002/07/13].
34.
go back to reference Fang J, Dagenais SL, Erickson RP, et al. Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome. Am J Hum Genet. 2000;67(6):1382–8. https://doi.org/10.1086/316915 [published Online First: 2000/11/15]. Fang J, Dagenais SL, Erickson RP, et al. Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome. Am J Hum Genet. 2000;67(6):1382–8. https://​doi.​org/​10.​1086/​316915 [published Online First: 2000/11/15].
35.
go back to reference Ostergaard P, Simpson MA, Connell FC, et al. Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome). Nat Genet. 2011;43(10):929–31. https://doi.org/10.1038/ng.923 [published Online First: 2011/09/06]. Ostergaard P, Simpson MA, Connell FC, et al. Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome). Nat Genet. 2011;43(10):929–31. https://​doi.​org/​10.​1038/​ng.​923 [published Online First: 2011/09/06].
37.
go back to reference Ostergaard P, Simpson MA, Brice G, et al. Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype. J Med Genet. 2011;48(4):251–5. https://doi.org/10.1136/jmg.2010.085563 [published Online First: 2011/01/27]. Ostergaard P, Simpson MA, Brice G, et al. Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype. J Med Genet. 2011;48(4):251–5. https://​doi.​org/​10.​1136/​jmg.​2010.​085563 [published Online First: 2011/01/27].
39.
go back to reference Keppler-Noreuil KM, Rios JJ, Parker VE, et al. PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation. Am J Med Genet A. 2015;167A(2):287–95. https://doi.org/10.1002/ajmg.a.36836 [published Online First: 2015/01/06]. Keppler-Noreuil KM, Rios JJ, Parker VE, et al. PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation. Am J Med Genet A. 2015;167A(2):287–95. https://​doi.​org/​10.​1002/​ajmg.​a.​36836 [published Online First: 2015/01/06].
41.
go back to reference Nagai Y, Aoyama K, Endo Y, et al. Lymphedema of the extremities developed as the initial manifestation of rheumatoid arthritis. Eur J Dermatol. 2007;17(2):175–6. Nagai Y, Aoyama K, Endo Y, et al. Lymphedema of the extremities developed as the initial manifestation of rheumatoid arthritis. Eur J Dermatol. 2007;17(2):175–6.
43.
go back to reference Stoberl C, Partsch H. [Erysipelas and lymphedema–egg or hen?]. Z Hautkr. 1987;62(1):56–62 [published Online First: 1987/01/01]. Stoberl C, Partsch H. [Erysipelas and lymphedema–egg or hen?]. Z Hautkr. 1987;62(1):56–62 [published Online First: 1987/01/01].
47.
go back to reference Kinmonth JB, Taylor GW, Tracy GD, et al. Primary lymphoedema; clinical and lymphangiographic studies of a series of 107 patients in which the lower limbs were affected. Br J Surg. 1957;45(189):1–9. https://doi.org/10.1002/bjs.18004518902 [published Online First: 1957/07/01]. Kinmonth JB, Taylor GW, Tracy GD, et al. Primary lymphoedema; clinical and lymphangiographic studies of a series of 107 patients in which the lower limbs were affected. Br J Surg. 1957;45(189):1–9. https://​doi.​org/​10.​1002/​bjs.​18004518902 [published Online First: 1957/07/01].
48.
go back to reference Partsch H, Stoberl C, Urbanek A, et al. Clinical use of indirect lymphography in different forms of leg edema. Lymphology. 1988;21(3):152–60 [published Online First: 1988/09/01]. Partsch H, Stoberl C, Urbanek A, et al. Clinical use of indirect lymphography in different forms of leg edema. Lymphology. 1988;21(3):152–60 [published Online First: 1988/09/01].
52.
go back to reference Lee BB, Andrade M, Antignani PL, et al. Diagnosis and treatment of primary lymphedema. Consensus document of the International Union of Phlebology (IUP)-2013. Int Angiol. 2013;32(6):541–74 [published Online First: 2013/11/12]. Lee BB, Andrade M, Antignani PL, et al. Diagnosis and treatment of primary lymphedema. Consensus document of the International Union of Phlebology (IUP)-2013. Int Angiol. 2013;32(6):541–74 [published Online First: 2013/11/12].
55.
go back to reference Henze E, Schelbert HR, Collins JD, et al. Lymphoscintigraphy with Tc-99m-labeled dextran. J Nucl Med. 1982;23(10):923–9 [published Online First: 1982/10/01]. Henze E, Schelbert HR, Collins JD, et al. Lymphoscintigraphy with Tc-99m-labeled dextran. J Nucl Med. 1982;23(10):923–9 [published Online First: 1982/10/01].
57.
go back to reference Szuba A, Shin WS, Strauss HW, et al. The third circulation: radionuclide lymphoscintigraphy in the evaluation of lymphedema. J Nucl Med. 2003;44(1):43–57 [published Online First: 2003/01/08]. Szuba A, Shin WS, Strauss HW, et al. The third circulation: radionuclide lymphoscintigraphy in the evaluation of lymphedema. J Nucl Med. 2003;44(1):43–57 [published Online First: 2003/01/08].
59.
go back to reference Aldrich MB, Guilliod R, Fife CE, et al. Lymphatic abnormalities in the normal contralateral arms of subjects with breast cancer-related lymphedema as assessed by near-infrared fluorescent imaging. Biomed Opt Express. 2012;3(6):1256–65. https://doi.org/10.1364/boe.3.001256 [published Online First: 2012/06/29]. Aldrich MB, Guilliod R, Fife CE, et al. Lymphatic abnormalities in the normal contralateral arms of subjects with breast cancer-related lymphedema as assessed by near-infrared fluorescent imaging. Biomed Opt Express. 2012;3(6):1256–65. https://​doi.​org/​10.​1364/​boe.​3.​001256 [published Online First: 2012/06/29].
60.
go back to reference Thomis S, Dams L, Fourneau I, et al. Correlation Between Clinical Assessment And Lymphofluoroscopy In Patients With Breast Cancer-Related Lymphedema: A Study Of Concurrent Validity. Lymphat Res Biol. 2020. https://doi.org/10.1089/lrb.2019.0090 [published Online First: 2020/03/27]. Thomis S, Dams L, Fourneau I, et al. Correlation Between Clinical Assessment And Lymphofluoroscopy In Patients With Breast Cancer-Related Lymphedema: A Study Of Concurrent Validity. Lymphat Res Biol. 2020. https://​doi.​org/​10.​1089/​lrb.​2019.​0090 [published Online First: 2020/03/27].
63.
go back to reference Nelzen O, Bergqvist D, Lindhagen A. The prevalence of chronic lower-limb ulceration has been underestimated: results of a validated population questionnaire. Br J Surg. 1996;83(2):255–8. [published Online First: 1996/02/01]. Nelzen O, Bergqvist D, Lindhagen A. The prevalence of chronic lower-limb ulceration has been underestimated: results of a validated population questionnaire. Br J Surg. 1996;83(2):255–8. [published Online First: 1996/02/01].
64.
go back to reference Charpy J, Audier M. Les troubles trophiques des membres inférieurs d’orgine veineuse: Masson. 1956. Charpy J, Audier M. Les troubles trophiques des membres inférieurs d’orgine veineuse: Masson. 1956.
67.
68.
go back to reference Maessen-Visch MB, Neumann HAM, Koedam MI, et al. Répercussions de l’atrophie blanche sur les patients atteints d’un ulcus cruris venosum. Phlébologie. 1997;50:367–70. Maessen-Visch MB, Neumann HAM, Koedam MI, et al. Répercussions de l’atrophie blanche sur les patients atteints d’un ulcus cruris venosum. Phlébologie. 1997;50:367–70.
69.
go back to reference Van der Veer G, Eekhof JAH, Walma EP, et al. NHG-standaarden voor de huisarts I: Elsevier/Bunge; 1999. pag. 349–55. Van der Veer G, Eekhof JAH, Walma EP, et al. NHG-standaarden voor de huisarts I: Elsevier/Bunge; 1999. pag. 349–55.
70.
go back to reference Püschel K, Hoops E, Lignitz E. Fatale blutungen aus unterschenkelvarizes. Phlebol u Proktol. 1987;16:162. Püschel K, Hoops E, Lignitz E. Fatale blutungen aus unterschenkelvarizes. Phlebol u Proktol. 1987;16:162.
74.
go back to reference Richtlijn ‘Diepe veneuze trombose en longembolie’: Kwaliteitsinstituut voor de gezondheidszorg CBO, 1999:26. Richtlijn ‘Diepe veneuze trombose en longembolie’: Kwaliteitsinstituut voor de gezondheidszorg CBO, 1999:26.
76.
go back to reference Kappert A. Phlegmasia coerulea dolens. Bern, Huber: Hringer H. Akute tiefe Becken- und Beinvenenthrombosen; 1977. Kappert A. Phlegmasia coerulea dolens. Bern, Huber: Hringer H. Akute tiefe Becken- und Beinvenenthrombosen; 1977.
77.
go back to reference Feuerstein W. Die diagnose des postthrombotischen syndroms. Phlebol u Proktol. 1979;8. Feuerstein W. Die diagnose des postthrombotischen syndroms. Phlebol u Proktol. 1979;8.
78.
go back to reference Lochner J, Agathos M, Geier J, et al. Die Bedeutung von Kontaktallergien bei der Behandlung alterer Menschen mit Stauungsdermatitis. Phlebologie. 1997;26:111–4. Lochner J, Agathos M, Geier J, et al. Die Bedeutung von Kontaktallergien bei der Behandlung alterer Menschen mit Stauungsdermatitis. Phlebologie. 1997;26:111–4.
79.
81.
go back to reference Peschen M, Vanscheidt W, Sigmund G, et al. Computertomographische und magnetresonanzttomographische Untersuchungen vor und nach paratibialer Fasziotomie. Hautarzt. 1996;47(7):521–5.CrossRef Peschen M, Vanscheidt W, Sigmund G, et al. Computertomographische und magnetresonanzttomographische Untersuchungen vor und nach paratibialer Fasziotomie. Hautarzt. 1996;47(7):521–5.CrossRef
82.
go back to reference Wittens C, Davies AH, Baekgaard N, et al. Editor’s choice – management of chronic venous disease: clinical practice guidelines of the european society for vascular surgery (ESVS). Eur J Vasc Endovasc Surg. 2015;49(6):678–737. https://doi.org/10.1016/j.ejvs.2015.02.007 [published Online First: 2015/04/30]. Wittens C, Davies AH, Baekgaard N, et al. Editor’s choice – management of chronic venous disease: clinical practice guidelines of the european society for vascular surgery (ESVS). Eur J Vasc Endovasc Surg. 2015;49(6):678–737. https://​doi.​org/​10.​1016/​j.​ejvs.​2015.​02.​007 [published Online First: 2015/04/30].
83.
go back to reference Conte MS, Pomposelli FB. Society for vascular surgery practice guidelines for atherosclerotic occlusive disease of the lower extremities management of asymptomatic disease and claudication. Introduction. J Vasc Surg. 2015;61(3 Suppl):1S. https://doi.org/10.1016/j.jvs.2014.12.006 [published Online First: 2015/02/28]. Conte MS, Pomposelli FB. Society for vascular surgery practice guidelines for atherosclerotic occlusive disease of the lower extremities management of asymptomatic disease and claudication. Introduction. J Vasc Surg. 2015;61(3 Suppl):1S. https://​doi.​org/​10.​1016/​j.​jvs.​2014.​12.​006 [published Online First: 2015/02/28].
85.
go back to reference Richtlijn Perifeer Arterieel Vaatlijden (PAV). In: (FMS) FMs, ed. Nederland, 2016. Richtlijn Perifeer Arterieel Vaatlijden (PAV). In: (FMS) FMs, ed. Nederland, 2016.
90.
go back to reference Cranendonk DR, Lavrijsen APM, Prins JM, et al. Cellulitis: current insights into pathophysiology and clinical management. Neth J Med. 2017;75(9):366–78 [published Online First: 2017/12/09]. Cranendonk DR, Lavrijsen APM, Prins JM, et al. Cellulitis: current insights into pathophysiology and clinical management. Neth J Med. 2017;75(9):366–78 [published Online First: 2017/12/09].
93.
go back to reference Eells SJ, Chira S, David CG, et al. Non-suppurative cellulitis: risk factors and its association with Staphylococcus aureus colonization in an area of endemic community-associated methicillin-resistant S. aureus infections. Epidemiol Infect. 2011;139(4):606–12. https://doi.org/10.1017/s0950268810001408 [published Online First: 2010/06/22]. Eells SJ, Chira S, David CG, et al. Non-suppurative cellulitis: risk factors and its association with Staphylococcus aureus colonization in an area of endemic community-associated methicillin-resistant S. aureus infections. Epidemiol Infect. 2011;139(4):606–12. https://​doi.​org/​10.​1017/​s095026881000140​8 [published Online First: 2010/06/22].
98.
go back to reference Monitoring and epidemiological assessment of mass drug administration in the global programme to eliminate lymphatic filariasis: a manual for national elimination programmes. In: Organization WH, ed. Geneva; 2011. Monitoring and epidemiological assessment of mass drug administration in the global programme to eliminate lymphatic filariasis: a manual for national elimination programmes. In: Organization WH, ed. Geneva; 2011.
99.
100.
go back to reference Organization WH. Guideline: alternative mass drug administration regimens to eliminate lymphatic filariasis; Licence: CC BY-NC-SA 3.0 IGO, 2017. Organization WH. Guideline: alternative mass drug administration regimens to eliminate lymphatic filariasis; Licence: CC BY-NC-SA 3.0 IGO, 2017.
102.
go back to reference Pani SP, Srividya A. Clinical manifestations of bancroftian filariasis with special reference to lymphoedema grading. Indian J Med Res. 1995;102:114–8 [published Online First: 1995/09/01]. Pani SP, Srividya A. Clinical manifestations of bancroftian filariasis with special reference to lymphoedema grading. Indian J Med Res. 1995;102:114–8 [published Online First: 1995/09/01].
103.
go back to reference Olszewski WL, Jamal S, Manokaran G, et al. Skin changes in filarial and non-filarial lymphoedema of the lower extremities. Trop Med Parasitol. 1993;44(1):40–4. [published Online First: 1993/03/01]. Olszewski WL, Jamal S, Manokaran G, et al. Skin changes in filarial and non-filarial lymphoedema of the lower extremities. Trop Med Parasitol. 1993;44(1):40–4. [published Online First: 1993/03/01].
105.
go back to reference Price E. Podoconiosis: non-filarial Elephantiasis. Oxford: Oxford Medical; 1990. Price E. Podoconiosis: non-filarial Elephantiasis. Oxford: Oxford Medical; 1990.
106.
108.
go back to reference Tekola-Ayele F, Wendemagegn E. Podoconiosis: tropical lymphedema of the lower legs. In: Ltd iP, ed. Dermatology and allergology – principles and practice. Hong Kong; 2014. Tekola-Ayele F, Wendemagegn E. Podoconiosis: tropical lymphedema of the lower legs. In: Ltd iP, ed. Dermatology and allergology – principles and practice. Hong Kong; 2014.
110.
go back to reference Griffiths C, Barker J, Bleiker T, et al. Rook’s textbook of dermatology; 9th revised edition: Wiley & sons; 2016. Griffiths C, Barker J, Bleiker T, et al. Rook’s textbook of dermatology; 9th revised edition: Wiley & sons; 2016.
Metagegevens
Titel
Medische diagnostiek
Auteurs
Robert Damstra, PhD, MD
Kristiana Gordon, PhD, MD
Malou van Zanten, PhD, PT
Sahar Mansour, PhD, MD
Kirsten van Duinen, MD
Sarah Thomis, MSc
Nele Devoogdt, PhD, PT
Inge Fourneau, PhD, MD
Sjan Lavrijsen, PhD, MD
Wendemagegn Enbiale, MD
Michette de Rooij, PhD, MD
Copyright
2021
Uitgeverij
Bohn Stafleu van Loghum
DOI
https://doi.org/10.1007/978-90-368-2590-0_2