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Gepubliceerd in:

15-07-2019

Mediators and moderators of change in mindfulness-based stress reduction for painful diabetic peripheral neuropathy

Auteurs: Karolina A. Rozworska, Patricia A. Poulin, Amanda Carson, Giorgio A. Tasca, Howard J. Nathan

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 2/2020

Abstract

Painful diabetic peripheral neuropathy (PDPN) is a chronic pain condition with modest response to pharmacotherapy. Participation in mindfulness-based stress reduction (MBSR) leads to improvements in pain-related outcomes but the mechanisms of change are unknown. The present study examined the mediators and moderators of change in 62 patients with PDPN who participated in a randomized controlled trial comparing MBSR to waitlist. Changes in mindfulness and pain catastrophizing were tested simultaneously as mediators. Increased mindfulness mediated the association between participation in MBSR and improved pain severity, pain interference, and the physical component of health-related quality of life (HRQoL) 3 months later. The mediation effect of pain catastrophizing was not significant. Linear moderated trends were also found. Post-hoc moderated mediation analyses suggested that MBSR patients with longer histories of diabetes might increase their mindfulness levels more, which in turn leads to improved pain severity and physical HRQoL. These results allow for a deeper understanding of pathways by which MBSR benefits patients with PDPN.

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Titel: Mediators and moderators of change in mindfulness-based stress reduction for painful diabetic peripheral neuropathy
Auteurs: Karolina A. Rozworska
Patricia A. Poulin
Amanda Carson
Giorgio A. Tasca
Howard J. Nathan
Publicatiedatum: 15-07-2019
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 2/2020
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-019-00079-4

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