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24-11-2017 | Original Paper | Uitgave 5/2018

Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 5/2018

Auteurs:: Andreia Carvalho Pereira, Inês R. Violante, Susana Mouga, Guiomar Oliveira, Miguel Castelo-Branco

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The online version of this article (https://doi.org/10.1007/s10803-017-3406-8) contains supplementary material, which is available to authorized users.

Abstract

The nature of neurochemical changes in autism spectrum disorder (ASD) remains controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high-functioning children and adolescents with ASD without associated comorbidities and fourteen controls. We observed reduced total N-acetylaspartate (tNAA) and total creatine, increased Glx/tNAA but unchanged glutamate + glutamine (Glx) and unchanged absolute or relative gamma-aminobutyric acid (GABA+) in the ASD group. Importantly, both smaller absolute and relative GABA+ levels were associated with worse communication skills and developmental delay scores assessed by the autism diagnostic interview—revised (ADI-R). We conclude that tNAA is reduced in the mPFC in ASD and that glutamatergic metabolism may be altered due to unbalanced Glx/tNAA. Moreover, GABA+ is related to autistic symptoms assessed by the ADI-R.

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Ajram, L. A., Horder, J., Mendez, M. A., Galanopoulos, A., Brennan, L. P., Wichers, R. H., et al. (2017). Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder. Translational Psychiatry, 7(5), e1137. https://doi.org/10.1038/tp.2017.104. PubMedPubMedCentralCrossRef

Alger, J. R. (2011). Quantitative proton magnetic resonance spectroscopy and spectroscopic imaging of the brain a didactic review. Topics in Magnetic Resonance Imaging: TMRI, 21(2), 115–128. CrossRef

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th edn.). Arlington: American Psychiatric Publishing. CrossRef

Arnold Anteraper, S., Triantafyllou, C., Sawyer, A. T., Hofmann, S. G., Gabrieli, J. D. & Whitfield-Gabrieli, S. (2014). Hyper-connectivity of subcortical resting-state networks in social anxiety disorder. Brain Connectivity, 4(2), 81–90. https://doi.org/10.1089/brain.2013.0180. PubMedCrossRef

Aoki, Y., Abe, O., Yahata, N., Kuwabara, H., Natsubori, T., Iwashiro, N., et al. (2012). Absence of age-related prefrontal NAA change in adults with autism spectrum disorders. Translational Psychiatry, 2(10), e178. https://doi.org/10.1038/tp.2012.108. PubMedPubMedCentralCrossRef

Aoki, Y., Kasai, K., & Yamasue, H. (2012). Age-related change in brain metabolite abnormalities in autism: A meta-analysis of proton magnetic resonance spectroscopy studies. Translational Psychiatry, 2(1), e69. https://doi.org/10.1038/tp.2011.65. PubMedPubMedCentralCrossRef

Apps, M. A. J., Rushworth, M. F. S., & Chang, S. W. C. (2016). The anterior cingulate gyrus and social cognition: Tracking the motivation of others. Neuron, 90(4), 692–707. https://doi.org/10.1016/j.neuron.2016.04.018. PubMedPubMedCentralCrossRef

Badre, D., & D’Esposito, M. (2007). Functional magnetic resonance imaging evidence for a hierarchical organization of the prefrontal cortex. Journal of Cognitive Neuroscience, 19, 2082–2099. https://doi.org/10.1162/jocn.2007.19.12.2082. PubMedCrossRef

Bartha, R. (2007). Effect of signal-to-noise ratio and spectral linewidth on metabolite quantification at 4 T. NMR in Biomedicine, 20(5), 512–521. https://doi.org/10.1002/nbm.1122. PubMedCrossRef

Bejjani, A., O’Neill, J., Kim, J. A., Frew, A. J., Yee, V. W., Ly, R., et al. (2012). Elevated glutamatergic compounds in pregenual anterior cingulate in pediatric autism spectrum disorder demonstrated by1H MRS and 1H MRSI. PLoS ONE, 7(7), e38786. https://doi.org/10.1371/journal.pone.0038786. PubMedPubMedCentralCrossRef

Benarroch, E. E. (2008). N-Acetylaspartate and N-acetylaspartylglutamate: Neurobiology and clinical significance. Neurology, 70(16), 1353–1357. https://doi.org/10.1212/01.wnl.0000311267.63292.6c. PubMedCrossRef

Benjamini, Y., & Hochberg, Y. (1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society, 57(1), 289–300. https://doi.org/10.2307/2346101.

Bollmann, S., Ghisleni, C., Poil, S.-S., Martin, E., Ball, J., Eich-Höchli, D., et al. (2015). Developmental changes in gamma-aminobutyric acid levels in attention-deficit/hyperactivity disorder. Translational Psychiatry, 5, e589. https://doi.org/10.1038/tp.2015.79. PubMedPubMedCentralCrossRef

Bozzi, Y., Provenzano, G., & Casarosa, S. (2017). Neurobiological bases of autism-epilepsy comorbidity: A focus on excitation/inhibition imbalance. European Journal of Neuroscience. https://doi.org/10.1111/ejn.13595. PubMed

Brix, M. K., Ersland, L., Hugdahl, K., Grüner, R., Posserud, M.-B., Hammar, Å, et al. (2015). Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited. Frontiers in Human Neuroscience, 9(June), 1–12. https://doi.org/10.3389/fnhum.2015.00365.

Brunsdon, V. Ea, & Happé, F. (2014). Exploring the “fractionation” of autism at the cognitive level. Autism: The International Journal of Research and Practice, 18(1), 17–30. https://doi.org/10.1177/1362361313499456. CrossRef

Cecil, K. M. (2013). Proton magnetic resonance spectroscopy: technique for the neuroradiologist. Neuroimaging Clinics of North America, 23(3), 381–392. https://doi.org/10.1016/j.nic.2012.10.003. PubMedPubMedCentralCrossRef

Chowdhury, F. A., O’Gorman, R. L., Nashef, L., Elwes, R. D., Edden, R. A., Murdoch, J. B., et al. (2015). Investigation of glutamine and GABA levels in patients with idiopathic generalized epilepsy using MEGAPRESS. Journal of Magnetic Resonance Imaging, 41(3), 694–699. https://doi.org/10.1002/jmri.24611. PubMedCrossRef

Chugani, D. C. (2012). Neuroimaging and neurochemistry of autism. Pediatric Clinics of North America, 59(1), 63–73. https://doi.org/10.1016/j.pcl.2011.10.002. PubMedCrossRef

Cleve, M., Gussew, A., & Reichenbach, J. R. (2015). In vivo detection of acute pain-induced changes of GABA + and Glx in the human brain by using functional 1H MEGA-PRESS MR spectroscopy. NeuroImage, 105, 67–75. https://doi.org/10.1016/j.neuroimage.2014.10.042. PubMedCrossRef

Cochran, D. M., Sikoglu, E. M., Hodge, S. M., Edden, R. a. E., Foley, A., Kennedy, D. N., et al. (2015). Relationship among glutamine, γ-aminobutyric acid, and social cognition in autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 25(4), 150428120459000. https://doi.org/10.1089/cap.2014.0112. CrossRef

Constantino, J. N., & Gruber, C. P. (2005). Social responsiveness scale (SRS). Los Angeles, CA: Western Psychological Services.

Daly, E., Ecker, C., Hallahan, B., Deeley, Q., Craig, M., Murphy, C., et al. (2014). Response inhibition and serotonin in autism: A functional MRI study using acute tryptophan depletion. Brain, 137(9), 2600–2610. https://doi.org/10.1093/brain/awu178. PubMedPubMedCentralCrossRef

DeVito, T. J., Drost, D. J., Neufeld, R. W. J., Rajakumar, N., Pavlosky, W., Williamson, P., & Nicolson, R. (2007). Evidence for cortical dysfunction in autism: A proton magnetic resonance spectroscopic imaging study. Biological Psychiatry, 61(4), 465–473. https://doi.org/10.1016/j.biopsych.2006.07.022. PubMedCrossRef

Drenthen, G. S., Barendse, E. M., Aldenkamp, A. P., van Veenendaal, T. M., Puts, N. A. J., Edden, R. A. E., et al. (2016). Altered neurotransmitter metabolism in adolescents with high-functioning autism. Psychiatry Research Neuroimaging, 256, 44–49. https://doi.org/10.1016/j.pscychresns.2016.09.007. PubMedCrossRef

Edden, R. A. E., & Barker, P. B. (2007). Spatial effects in the detection of γ-aminobutyric acid: Improved sensitivity at high fields using inner volume saturation. Magnetic Resonance in Medicine, 58(6), 1276–1282. https://doi.org/10.1002/mrm.21383. PubMedCrossRef

Edden, R. A. E., Pomper, M. G., & Barker, P. B. (2007). In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 T. Magnetic Resonance in Medicine, 57(6), 977–982. https://doi.org/10.1002/mrm.21234. PubMedCrossRef

Ende, G. (2015). Proton magnetic resonance spectroscopy: Relevance of glutamate and GABA to neuropsychology. Neuropsychology Review, 25(3), 315–325. https://doi.org/10.1007/s11065-015-9295-8. PubMedCrossRef

Fatemi, S. H., Halt, A. R., Stary, J. M., Kanodia, R., Schulz, S. C., & Realmuto, G. R. (2002). Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices. Biological Psychiatry, 52(8), 805–810. https://doi.org/10.1016/S0006-3223(02)01430-0. PubMedCrossRef

Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Rooney, R. J., Patel, D. H., & Thuras, P. D. (2010). mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism. Journal of Autism and Developmental Disorders, 40(6), 743–750. https://doi.org/10.1007/s10803-009-0924-z. PubMedPubMedCentralCrossRef

Fatemi, S. H., Reutiman, T. J., Folsom, T. D., & Thuras, P. D. (2009). GABA(A) receptor downregulation in brains of subjects with autism. Journal of Autism and Developmental Disorders, 39(2), 223–230. https://doi.org/10.1007/s10803-008-0646-7. PubMedCrossRef

Faul, F., Erdfelder, E., Buchner, A., & Lang, A.-G. (2009). Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behavior Research Methods, 41(4), 1149–1160. https://doi.org/10.3758/BRM.41.4.1149. PubMedCrossRef

Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007). G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2), 175–191. https://doi.org/10.3758/BF03193146. PubMedCrossRef

Fombonne, E. (2003). Epidemiological surveys of autism and other pervasive developmental disorders: an update. Journal of autism and developmental disorders, 33(4), 365–382. http://www.ncbi.nlm.nih.gov/pubmed/12959416.

Ford, T. C., & Crewther, D. P. (2016). A Comprehensive review of the 1H-MRS metabolite spectrum in autism spectrum disorder. Frontiers in Molecular Neuroscience. https://doi.org/10.3389/fnmol.2016.00014. PubMedPubMedCentral

Fujii, E., Mori, K., Miyazaki, M., Hashimoto, T., Harada, M., & Kagami, S. (2010). Function of the frontal lobe in autistic individuals: a proton magnetic resonance spectroscopic study. The journal of medical investigation: JMI, 57(1–2), 35–44. http://www.ncbi.nlm.nih.gov/pubmed/20299741.

Gaetz, W., Bloy, L., Wang, D. J., Port, R. G., Blaskey, L., Levy, S. E., & Roberts, T. P. L. (2014). GABA estimation in the brains of children on the autism spectrum: Measurement precision and regional cortical variation. NeuroImage, 86, 1–9. https://doi.org/10.1016/j.neuroimage.2013.05.068. PubMedCrossRef

Gasparovic, C., Song, T., Devier, D., Bockholt, H. J., Caprihan, A., Mullins, P. G., et al. (2006). Use of tissue water as a concentration reference for proton spectroscopic imaging. Magnetic Resonance in Medicine, 55(6), 1219–1226. https://doi.org/10.1002/mrm.20901. PubMedCrossRef

Geschwind, D. H. (2009). Advances in autism. Annual Review of Medicine, 60, 367–380. https://doi.org/10.1146/annurev.med.60.053107.121225. PubMedPubMedCentralCrossRef

Goji, A., Ito, H., Mori, K., Harada, M., Hisaoka, S., Toda, Y., et al. (2017). Assessment of anterior cingulate cortex (ACC) and left cerebellar metabolism in asperger’s syndrome with proton magnetic resonance spectroscopy (MRS). Plos ONE, 12(1), e0169288. https://doi.org/10.1371/journal.pone.0169288. PubMedPubMedCentralCrossRef

Harada, M., Taki, M. M., Nose, A., Kubo, H., Mori, K., Nishitani, H., & Matsuda, T. (2011). Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 T instrument. Journal of Autism and Developmental Disorders, 41(4), 447–454. https://doi.org/10.1007/s10803-010-1065-0. PubMedCrossRef

Harris, A. D., Puts, N. A. J., & Edden, R. A. E. (2015). Tissue correction for GABA-edited MRS: Considerations of voxel composition, tissue segmentation, and tissue relaxations. Journal of Magnetic Resonance Imaging, 42(5), 1431–1440. https://doi.org/10.1002/jmri.24903. PubMedPubMedCentralCrossRef

Hashimoto, T., Sasaki, M., Sugai, K., Hanaoka, S., Fukumizu, M., Kato, T., et al. (2001). Paroxysmal discharges on EEG in young autistic patients are frequent in frontal regions. Journal of Medical Investigation, 48(3–4), 175–180. http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L33545846%5Cnhttp://sfx.library.uu.nl/utrecht?sid=EMBASE&issn=13431420&id=doi:&atitle=Paroxysmal+discharges+on+EEG+in+young+autistic+patients+are+frequent+in+frontal+regions.&stitle=. PubMed

Hassan, T. H., Abdelrahman, H. M., Abdel Fattah, N. R., El-Masry, N. M., Hashim, H. M., El-Gerby, K. M., & Abdel Fattah, N. R. (2013). Blood and brain glutamate levels in children with autistic disorder. Research in Autism Spectrum Disorders, 7(4), 541–548. https://doi.org/10.1016/j.rasd.2012.12.005. CrossRef

Hodge, S. M., Makris, N., Kennedy, D. N., Caviness, V. S., Howard, J., McGrath, L., et al. (2010). Cerebellum, language, and cognition in autism and specific language impairment. Journal of Autism and Developmental Disorders, 40(3), 300–316. https://doi.org/10.1007/s10803-009-0872-7. PubMedPubMedCentralCrossRef

Horder, J., Lavender, T., Mendez, M., O’Gorman, R., Daly, E., Craig, M. C., et al. (2013). Reduced subcortical glutamate/glutamine in adults with autism spectrum disorders: a [ ¹H]MRS study. Translational Psychiatry, 3(April), e279. https://doi.org/10.1038/tp.2013.53. PubMedPubMedCentralCrossRef

Ipser, J. C., Syal, S., Bentley, J., Adnams, C. M., Steyn, B., & Stein, D. J. (2012). 1H-MRS in autism spectrum disorders: A systematic meta-analysis. Metabolic Brain Disease, 27(3), 275–287. https://doi.org/10.1007/s11011-012-9293-y. PubMedCrossRef

Ito, H., Mori, K., Harada, M., Hisaoka, S., Toda, Y., Mori, T., et al. (2017). A proton magnetic resonance spectroscopic study in autism spectrum disorder using a 3-tesla clinical magnetic resonance imaging (MRI) System: The anterior cingulate cortex and the left cerebellum. Journal of Child Neurology, 32(8), 88307381770298. https://doi.org/10.1177/0883073817702981. CrossRef

Joshi, G., Biederman, J., Wozniak, J., Goldin, R. L., Crowley, D., Furtak, S., et al. (2013). Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: A pilot study at 4T. European Archives of Psychiatry and Clinical Neuroscience, 263(5), 379–384. https://doi.org/10.1007/s00406-012-0369-9. PubMedCrossRef

Kubas, B., Kułak, W., Sobaniec, W., Tarasow, E., Lebkowska, U., & Walecki, J. (2012). Metabolite alterations in autistic children: a 1H MR spectroscopy study. Advances in Medical Sciences, 57(1), 152–156. https://doi.org/10.2478/v10039-012-0014-x. PubMedCrossRef

Lai, M.-C., Lombardo, M. V., & Baron-Cohen, S. (2014). Autism. The Lancet, 383(9920), 896–910. https://doi.org/10.1016/S0140-6736(13)61539-1. CrossRef

Landim, R. C. G., Edden, R. A. E., Foerster, B., Li, L. M., Covolan, R. J. M., & Castellano, G. (2015). Investigation of NAA and NAAG dynamics underlying visual stimulation using MEGA-PRESS in a functional MRS experiment. Magnetic Resonance Imaging, 34(3), 239–245. https://doi.org/10.1016/j.mri.2015.10.038. PubMedPubMedCentralCrossRef

Letzkus, J. J., Wolff, S. B. E., & Luthi, A. (2015). Disinhibition, a circuit mechanism for associative learning and memory. Neuron, 88(2), 264–276. https://doi.org/10.1016/j.neuron.2015.09.024. PubMedCrossRef

Lever, A. G., & Geurts, H. M. (2016). Psychiatric Co-occurring symptoms and disorders in young, middle-aged, and older adults with autism spectrum disorder. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-016-2722-8. PubMedPubMedCentral

Li, C. T., Lu, C. F., Lin, H. C., Huang, Y. Z., Juan, C. H., Su, T. P., et al. (2017). Cortical inhibitory and excitatory function in drug-naive generalized anxiety disorder. Brain Stimulation, 10(3), 604–608. https://doi.org/10.1016/j.brs.2016.12.007. PubMedCrossRef

Long, Z., Dyke, J. P., Ma, R., Huang, C. C., Louis, E. D., & Dydak, U. (2015). Reproducibility and effect of tissue composition on cerebellar γ-aminobutyric acid (GABA) MRS in an elderly population. NMR in Biomedicine, 28(10), 1315–1323. https://doi.org/10.1002/nbm.3381. PubMedPubMedCentralCrossRef

Lord, C., Rutter, M., DiLavore, P., & Risis, S. (1999). Autism diagnostic observation schedule (ADOS). Los Angeles: Western Psychological Services.

Maddock, R. J., Casazza, G. A., Fernandez, D. H., & Maddock, M. I. (2016). Acute modulation of cortical glutamate and GABA content by physical activity. Journal of Neuroscience, 36(8), 2449–2457. https://doi.org/10.1523/JNEUROSCI.3455-15.2016. PubMedCrossRef

Maltezos, S., Horder, J., Coghlan, S., Skirrow, C., O’Gorman, R., Lavender, T. J., et al. (2014). Glutamate/glutamine and neuronal integrity in adults with ADHD: a proton MRS study. Translational Psychiatry, 4(3), e373. https://doi.org/10.1038/tp.2014.11. PubMedPubMedCentralCrossRef

Marín, O. (2012). Interneuron dysfunction in psychiatric disorders. Nature Reviews Neuroscience, 13(2), 107–120. https://doi.org/10.1038/nrn3155. PubMedCrossRef

Markram, H., Rinaldi, T., & Markram, K. (2007). The intense world syndrome–an alternative hypothesis for autism. Frontiers in Neuroscience, 1(1), 77–96. https://doi.org/10.3389/neuro.01.1.1.006.2007. PubMedPubMedCentralCrossRef

Mendez, M. A., Horder, J., Myers, J., Coghlan, S., Stokes, P., Erritzoe, D., et al. (2013). The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: A pilot [11C]Ro15–4513 positron emission tomography study. Neuropharmacology, 68, 195–201. https://doi.org/10.1016/j.neuropharm.2012.04.008. PubMedCrossRef

Mescher, M., Merkle, H., Kirsch, J., Garwood, M., & Gruetter, R. (1998). Simultaneous in vivo spectral editing and water suppression. NMR in Biomedicine, 11(6), 266–272. https://doi.org/10.1002/(SICI)1099-1492(199810)11:6<266::AID-NBM530>3.0.CO;2-J PubMedCrossRef

Mlynrik, V., Gruber, S., & Moser, E. (2001). Proton T1 and T2 relaxation times of human brain metabolites at 3 T. NMR in Biomedicine, 14(5), 325–331. https://doi.org/10.1002/nbm.713. CrossRef

Moffett, J. R., Arun, P., Ariyannur, P. S., & Namboodiri, A. M. A. (2013). N-Acetylaspartate reductions in brain injury: Impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation. Frontiers in Neuroenergetics, 5(DEC), 1–19. https://doi.org/10.3389/fnene.2013.00011.

Mori, K., Toda, Y., Ito, H., Mori, T., Goji, A., Fujii, E., et al. (2013). A proton magnetic resonance spectroscopic study in autism spectrum disorders: Amygdala and orbito-frontal cortex. Brain and Development, 35(2), 139–145. https://doi.org/10.1016/j.braindev.2012.09.016. PubMedCrossRef

Mori, T., Mori, K., Fujii, E., Toda, Y., Miyazaki, M., Harada, M., et al. (2012). Evaluation of the GABAergic nervous system in autistic brain: 123I-iomazenil SPECT study. Brain and Development, 34(8), 648–654. https://doi.org/10.1016/j.braindev.2011.10.007. PubMedCrossRef

Morris, L. S., Baek, K., & Voon, V. (2016). Distinct cortico-striatal connections with subthalamic nucleus underlie facets of compulsivity. Cortex, 88, 143–150. https://doi.org/10.1016/j.cortex.2016.12.018. PubMedCrossRef

Mouga, S., Café, C., Almeida, J., Marques, C., Duque, F., & Oliveira, G. (2016). Intellectual profiles in the autism spectrum and other neurodevelopmental disorders. Journal of Autism and Developmental Disorders, 46(9), 2940–2955. https://doi.org/10.1007/s10803-016-2838-x. PubMedCrossRef

Murphy, D. (2002). Asperger syndrome: a proton magnetic resonance spectroscopy study of brain. Archives of General Psychiatry, 59(NOVEMBER), 885–891. http://archpsyc.jamanetwork.com/article.aspx?articleid=206824.

Naaijen, J., Lythgoe, D. J., Amiri, H., Buitelaar, J. K., & Glennon, J. C. (2015). Fronto-striatal glutamatergic compounds in compulsive and impulsive syndromes: A review of magnetic resonance spectroscopy studies. Neuroscience and Biobehavioral Reviews, 52, 74–88. https://doi.org/10.1016/j.neubiorev.2015.02.009. PubMedCrossRef

Neale, J. H., Bzdega, T., & Wroblewska, B. (2000). N-acetylaspartylglutamate: The most abundant peptide neurotransmitter in the mammalian central nervous system. Journal of Neurochemistry, 75(2), 443–452. https://doi.org/10.1046/j.1471-4159.2000.0750443.x. PubMedCrossRef

O’Gorman, R. L., Michels, L., Edden, R. A., Murdoch, J. B., & Martin, E. (2011). In vivo detection of GABA and glutamate with MEGA-PRESS: Reproducibility and gender effects. Journal of Magnetic Resonance Imaging, 33(5), 1262–1267. https://doi.org/10.1002/jmri.22520. PubMedPubMedCentralCrossRef

Oblak, a, Gibbs, T. T., & Blatt, G. J. (2009). Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism. Autism Research : Official Journal of the International Society for Autism Research, 2(4), 205–219. https://doi.org/10.1002/aur.88. CrossRef

Oblak, A. L., Gibbs, T. T., & Blatt, G. J. (2010). Decreased GABAB receptors in the cingulate cortex and fusiform gyrus in Autism. Journal of Neurochemistry, 114(5), 1414–1423. https://doi.org/10.1111/j.1471-4159.2010.06858.x. PubMedPubMedCentral

Oliveira, G., Ataide, A., Marques, C., Miguel, T. S., Coutinho, A. M., Mota-Vieira, L., et al. (2007). Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions. Developmental Medicine & Child Neurology, 49(10), 726–733. https://doi.org/10.1111/j.1469-8749.2007.00726.x. CrossRef

Patel, T., Blyth, J. C., Griffiths, G., Kelly, D., & Talcott, J. B. (2014). Moderate relationships between NAA and cognitive ability in healthy adults: implications for cognitive spectroscopy. Frontiers in Human Neuroscience, 8(February), 39. https://doi.org/10.3389/fnhum.2014.00039. PubMedPubMedCentral

Port, R. G., Gaetz, W., Bloy, L., Wang, D. J., Blaskey, L., Kuschner, E. S., et al. (2016). Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD. Autism Research. https://doi.org/10.1002/aur.1686. PubMedPubMedCentral

Pouwels, P. J. W., & Frahm, J. (1997). Differential distribution of NAA and NAAG in human brain as determined by quantitative localized proton MRS. NMR in Biomedicine, 10(2), 73–78. https://doi.org/10.1002/(SICI)1099-1492(199704)10:2<73::AID-NBM448>3.0.CO;2-4 PubMedCrossRef

Provencher, S. (1993). Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic Resonance in Medicine, 30(6), 672–679 PubMedCrossRef

Provencher, S. W. (2001). Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR in Biomedicine, 14(4), 260–264. https://doi.org/10.1002/nbm.698. PubMedCrossRef

Puts, N. A. J., Wodka, E. L., Harris, A. D., Crocetti, D., Tommerdahl, M., Mostofsky, S. H., & Edden, R. A. E. (2016). Reduced GABA and altered somatosensory function in children with autism spectrum disorder. Autism Research, 10, 608–619. https://doi.org/10.1002/aur.1691. PubMedPubMedCentralCrossRef

Rae, C. D. (2014). A guide to the metabolic pathways and function of metabolites observed in human brain 1H magnetic resonance spectra. Neurochemical Research, 39(1), 1–36. https://doi.org/10.1007/s11064-013-1199-5. PubMedCrossRef

Ribeiro, M. J., Violante, I. R., Bernardino, I., Edden, R. A. E., & Castelo-Branco, M. (2015). Abnormal relationship between GABA, neurophysiology and impulsive behavior in neurofibromatosis type 1. Cortex, 64, 194–208. https://doi.org/10.1016/j.cortex.2014.10.019. PubMedCrossRef

Robertson, C. E., Ratai, E.-M., & Kanwisher, N. (2015). Reduced GABAergic action in the autistic brain. Current Biology, 26(1), 80–85. https://doi.org/10.1016/j.cub.2015.11.019. PubMedCrossRef

Rojas, D. C., Becker, K. M., & Wilson, L. B. (2014a). Magnetic resonance spectroscopy studies of glutamate and GABA in autism: Implications for excitation-inhibition imbalance theory. Current Developmental Disorders Reports, 2, 46–57. https://doi.org/10.1007/s40474-014-0032-4. CrossRef

Rojas, D. C., Singel, D., Steinmetz, S., Hepburn, S., & Brown, M. S. (2014b). Decreased left perisylvian GABA concentration in children with autism and unaffected siblings. NeuroImage, 86, 28–34. https://doi.org/10.1016/j.neuroimage.2013.01.045. PubMedCrossRef

Rowland, L. M., Krause, B. W., Wijtenburg, S., McMahon, R. P., Chiappelli, J., Nugent, K. L., et al. (2015). Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study. Molecular Psychiatry. https://doi.org/10.1038/mp.2015.34. PubMedPubMedCentral

Rubenstein, J. L. R., & Merzenich, M. M. (2003). Model of autism : increased ratio of excitation / inhibition in key neural systems. Genes, Brain and Behavior, 2(5), 255–267. https://doi.org/10.1046/j.1601-183X.2003.00037.x. CrossRef

Rutter, M., Bailey, A., & Lord, C. (2003). Social communication questionnaire. Los Angeles: Western Psychological Services.

Rutter, M., Le Couteur, A., & Lord, C. (2003). The autism diagnostic interview-revised (ADI-R). Los Angeles, CA: Western Psychological Services.

Scholl, J., Kolling, N., Nelissen, N., Stagg, C. J., Harmer, C. J., & Rushworth, M. F. (2017). Excitation and inhibition in anterior cingulate predict use of past experiences. eLife, 6, 1–15. https://doi.org/10.7554/eLife.20365. CrossRef

Schür, R. R., Draisma, L. W. R., Wijnen, J. P., Boks, M. P., Koevoets, M. G. J. C., Joëls, M., et al. (2016). Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of ¹ H-MRS studies. Human Brain Mapping, 37(April), 3337–3352. https://doi.org/10.1002/hbm.23244. PubMedCrossRef

Shungu, D. C., Mao, X., Gonzales, R., Soones, T. N., Dyke, J. P., van der Veen, J. W., & Kegeles, L. S. (2016). Brain gamma-aminobutyric acid (GABA) detection in vivo with the J-editing 1H MRS technique: a comprehensive methodological evaluation of sensitivity enhancement, macromolecule contamination and test-retest reliability. NMR in Biomedicine, 29(7), 932–942. https://doi.org/10.1002/nbm.3539. PubMedPubMedCentralCrossRef

Solleveld, M., Schrantee, A., Puts, N., Reneman, L., & Lucassen, P. (2017). Age-dependent, lasting effects of methylphenidate on the GABAergic system of ADHD patients. NeuroImage: Clinical. https://doi.org/10.1016/j.nicl.2017.06.003.

Spence, S. J., & Schneider, M. T. (2009). The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatric Research, 65(5), 5A–5A. https://doi.org/10.1203/01.pdr.0000352115.41382.65. CrossRef

Takahashi, H., Katayama, K., Sohya, K., Miyamoto, H., Prasad, T., Matsumoto, Y., et al. (2012). Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction. Nature Neuroscience, 15(3), 389–398. https://doi.org/10.1038/nn.3040. PubMedPubMedCentralCrossRef

Tebartz Van Elst, L., Maier, S., Fangmeier, T., Endres, D., Mueller, G., Nickel, K., et al. (2014). Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance hypothesis. Molecular Psychiatry, 19(12), 1314–132562. https://doi.org/10.1038/mp.2014.62. CrossRef

Van Overwalle, F. (2009). Social cognition and the brain: A meta-analysis. Human Brain Mapping, 30(3), 829–858. https://doi.org/10.1002/hbm.20547. PubMedCrossRef

Varghese, M., Keshav, N., Jacot-Descombes, S., Warda, T., Wicinski, B., Dickstein, D. L., et al. (2017). Autism spectrum disorder: neuropathology and animal models. Acta Neuropathologica, 134(4), 537–566. https://doi.org/10.1007/s00401-017-1736-4. PubMedCrossRef

Violante, I. R., Patricio, M., Bernardino, I., Rebola, J., Abrunhosa, A. J., Ferreira, N., & Castelo-Branco, M. (2016). GABA deficiency in NF1. Neurology, 87(9), 897–904. https://doi.org/10.1212/WNL.0000000000003044. PubMedPubMedCentralCrossRef

Violante, I. R., Ribeiro, M. J., Edden, R. A. E., Guimares, P., Bernardino, I., Rebola, J., et al. (2013). GABA deficit in the visual cortex of patients with neurofibromatosis type 1: Genotype-phenotype correlations and functional impact. Brain, 136(3), 918–925. https://doi.org/10.1093/brain/aws368. PubMedCrossRef

Wechsler, D. (2008). Manual for intelligence scale for adults. Portuguese version (M.R. Simões, A. M. Rocha, and C. Ferreira. Lisboa: Cegoc-Tea.

Wechsler, D., Simoes, M. R., Rocha, A. M., & Ferreira, C. (2003). Wechsler Intelligence Scale for Children—Portuguese version. Lisboa: Cegoc-Tea.

World Health Organization. (1992). ICD-10 classifications of mental and behavioural disorder clinical descriptions and diagnostic guidelines. Geneva: World Health Organization.

Yasuhara, A. (2010). Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). Brain and Development, 32(10), 791–798. https://doi.org/10.1016/j.braindev.2010.08.010. PubMedCrossRef

Zaroff, C. M., & Uhm, S. Y. (2012). Prevalence of autism spectrum disorders and influence of country of measurement and ethnicity. Social Psychiatry and Psychiatric Epidemiology, 47(3), 395–398. https://doi.org/10.1007/s00127-011-0350-3. PubMedCrossRef

Zikopoulos, B., & Barbas, H. (2013). Altered neural connectivity in excitatory and inhibitory cortical circuits in autism. Frontiers in Human Neuroscience, 7(September), 609. https://doi.org/10.3389/fnhum.2013.00609. PubMedPubMedCentral

Titel: Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels
Auteurs:: Andreia Carvalho Pereira
Inês R. Violante
Susana Mouga
Guiomar Oliveira
Miguel Castelo-Branco
Publicatiedatum: 24-11-2017
DOI: https://doi.org/10.1007/s10803-017-3406-8
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 5/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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