Swipe om te navigeren naar een ander artikel
To further our understanding of the relationships between asthma control and health-related quality of life (HRQOL) and provide insights into the relative usefulness of various measures in different research contexts. We present a conceptual model and test it with longitudinal survey data.
Participants recruited via population sampling and hospital Emergency Departments completed questionnaires every 6 months for up to 3 years. Measures included: sleep disturbance, use of short-acting beta agonists (SABA), activity limitation, urgent medical visits, hospital use, Marks’ Asthma Quality of Life Questionnaire (AQLQ-M) and the SF-36 Health Survey. Correlation analysis and multi-level models tested predictions from the conceptual model.
A total of 213 people with asthma aged 16–75 years provided 967 observations. Correlations between asthma control and asthma-specific HRQOL were stronger than those between asthma control and generic HRQOL. The asthma control variables explained 54–58% of the variance in asthma-specific HRQOL and 8–25% of the variance in generic HRQOL. Activity limitation was the main contributor to between-person variation, while sleep disturbance and SABA use were the main contributors to within-person variation.
Sleep disturbance and SABA use may be most useful in evaluating treatment effectiveness, while activity limitation may be better when monitoring the impact of asthma in populations.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Marks, G. B. (2000). Current methods in measuring health-related quality of life in adults with asthma. In K. B. Weiss, A. S. Buist, & S. D. Sullivan (Eds.), Asthma’s impact on society (pp. 127–180). New York: Marcel Dekker.
Rutten-van Mölken, M., Custers, F., van Doorslaer, E., et al. (1995). Comparison of performance of four instruments in evaluating the effects of salmeterol on asthma quality of life. The European Respiratory Journal, 8, 888–898. PubMed
Vollmer, W. M., Markson, L. E., O’Connor, E., et al. (1999). Association of asthma control with health care utilization and quality of life. American Journal of Respiratory and Critical Care Medicine, 160(5), 1647–1652. PubMed
Katz, P. P., Yelin, E. H., Eisner, M. D., et al. (2002). Perceived control of asthma and quality of life among adults with asthma. Annals of Allergy, Asthma & Immunology, 89(3), 251–258. CrossRef
Moy, M. L., Israel, E., Weiss, S. T., et al. (2001). Clinical predictors of health-related quality of life depend on asthma severity. American Journal of Respiratory and Critical Care Medicine, 163(4), 924–929. PubMed
Vollmer, W. M. (2004). Assessment of asthma control and severity. Annals of Allergy, Asthma & Immunology, 93(5), 409–413. (quiz 414–406).
Ware, J. E., Snow, K. K., Kosinski, M., et al. (1993). SF-36 health survey manual and interpretation guide. Boston: The Health Institute, New England Medical Centre.
Ware, J. E., Kosinski, M., & Keller, S. D. (1994). SF-36 physical and mental health summary scales: A user’s manual. Boston: Health Assessment Lab.
Australian Bureau of Statistics (ABS). (1997). National health survey: SF36 population norms, Australia. Canberra: ABS.
SAS Institute Inc. (1999). SAS/STAT user’s guide, version 8. Cary, NC: SAS Institute Inc.
Fayers, P. M., & Machin, D. (2000). Quality of life: Assessment, analysis and interpretation (1st ed.). Chichester: Wiley.
Goldstein, H. (1995). Multilevel statistical models (2nd ed.). London: Arnold.
Snijders, T. B., & Bosker, R. (1999). Chapter 7: How much does the model explain? In Multilevel analysis: An introduction to basic and advanced multilevel modelling (pp. 99–108). London: Sage.
Osoba, D., & King, M. (2005). Interpreting QOL in individuals and groups: Meaningful differences. In P. Fayers & R. Hays (Eds.), Assessing quality of life in clinical trials (2nd ed., pp. 243–257). Oxford: Oxford University Press.
- Measures of asthma control and quality of life: longitudinal data provide practical insights into their relative usefulness in different research contexts
Madeleine T. King
Patricia M. Kenny
Guy B. Marks
- Springer Netherlands