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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2013

01-07-2013 | Original Paper

Maternal Vitamin D Levels and the Autism Phenotype Among Offspring

Auteurs: Andrew J. O. Whitehouse, Barbara J. Holt, Michael Serralha, Patrick G. Holt, Prue H. Hart, Merci M. H. Kusel

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2013

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Abstract

We tested whether maternal vitamin D insufficiency during pregnancy is related to the autism phenotype. Serum 25(OH)-vitamin D concentrations of 929 women were measured at 18 weeks’ pregnancy. The mothers of the three children with a clinical diagnosis of autism spectrum disorder had 25(OH)-vitamin D concentrations above the population mean. The offspring of 406 women completed the Autism-Spectrum Quotient in early adulthood. Maternal 25(OH)-vitamin D concentrations were unrelated to offspring scores on the majority of scales. However, offspring of mothers with low 25(OH)-vitamin D concentrations (<49 nmol/L) were at increased risk for ‘high’ scores (≥2SD above mean) on the Attention Switching subscale (odds ratio: 5.46, 95 % confidence interval: 1.29, 23.05). The involvement of maternal vitamin D during pregnancy in autism requires continued investigation.
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Metagegevens
Titel
Maternal Vitamin D Levels and the Autism Phenotype Among Offspring
Auteurs
Andrew J. O. Whitehouse
Barbara J. Holt
Michael Serralha
Patrick G. Holt
Prue H. Hart
Merci M. H. Kusel
Publicatiedatum
01-07-2013
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-012-1676-8