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Gepubliceerd in: Journal of Autism and Developmental Disorders 8/2020

07-02-2020 | Original Paper

Maternal Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Risk for Autism Spectrum Disorders in Offspring: A Meta-analysis

Auteurs: Zhixian Zhu, Shiming Tang, Xiaopeng Deng, Ying Wang

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2020

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Abstract

This study assessed the relationships between maternal systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) and risk for autism spectrum disorders (ASDs) in offspring. Seven observational studies, including 25,005 ASD cases and 4,543,321 participants, were included for meta-analysis. Pooled results by using random-effects models suggested that maternal RA was associated with an increased risk for ASDs [odds ratio (OR) 1.39, 95% confidence interval (CI) 1.16–1.67], while maternal SLE was associated with an increased risk for ASDs only in western population (OR 1.91, 95% CI 1.02–3.57). Further study is warranted to confirm these results.
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Metagegevens
Titel
Maternal Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Risk for Autism Spectrum Disorders in Offspring: A Meta-analysis
Auteurs
Zhixian Zhu
Shiming Tang
Xiaopeng Deng
Ying Wang
Publicatiedatum
07-02-2020
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 8/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-020-04400-y

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