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Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2015

01-06-2015 | Original Paper

Maternal Smoking and Autism Spectrum Disorder: A Meta-analysis

Auteurs: Brittany N. Rosen, Brian K. Lee, Nora L. Lee, Yunwen Yang, Igor Burstyn

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2015

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Abstract

We conducted a meta-analysis of 15 studies on maternal prenatal smoking and ASD risk in offspring. Using a random-effects model, we found no evidence of an association (summary OR 1.02, 95 % CI 0.93–1.12). Stratifying by study design, birth year, type of healthcare system, and adjustment for socioeconomic status or psychiatric history did not alter the findings. There was evidence that ascertaining exposure at the time of birth produced a lower summary OR than when this information was gathered after birth. There was no evidence of publication bias. Non-differential exposure misclassification was shown to have the potential for negligible influence on the results. We found no evidence to support a measurable association between maternal prenatal smoking and ASD in offspring.
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Metagegevens
Titel
Maternal Smoking and Autism Spectrum Disorder: A Meta-analysis
Auteurs
Brittany N. Rosen
Brian K. Lee
Nora L. Lee
Yunwen Yang
Igor Burstyn
Publicatiedatum
01-06-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-014-2327-z

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