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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2014

01-07-2014 | Original Paper

Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay

Auteurs: Kristen Lyall, Paul Ashwood, Judy Van de Water, Irva Hertz-Picciotto

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2014

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Abstract

The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD).
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Metagegevens
Titel
Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay
Auteurs
Kristen Lyall
Paul Ashwood
Judy Van de Water
Irva Hertz-Picciotto
Publicatiedatum
01-07-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-2017-2

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