Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

12-05-2021 | Original Paper

Maternal Exposure to Pesticides and Risk of Autism Spectrum Disorders in Offspring: A Meta-analysis

Auteurs: Li Wang, Shiming Tang, Songjie Wu, Lihua Yao, Dezhen Su, Ying Wang

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2022

Abstract

This meta-analysis was conducted to estimate the overall association between maternal exposure to pesticides and risk of ASD in offspring. PubMed, EMBASE, Web of Science, and the PsycINFO were searched until December 30, 2020 to include eligible studies. Eight studies with 50,426 participants, 5810 of whom had ASD, were involved in the study. Overall, the summary OR (95% confidence interval) of ASDs in offspring for maternal exposure to pesticide estimated by residential proximity measures and self-report was 1.88 (1.10–3.20). However, maternal exposure to pesticide measured by biomarkers was not associated with an increased risk of ASDs (pooled OR 1.13; 95% CI 0.83–1.54). Further well-designed studies are needed to confirm our findings.

vorige artikel Intervention Services for Autistic Adults: An ASDEU Study of Autistic Adults, Carers, and Professionals’ Experiences

volgende artikel Early Reading Comprehension Intervention for Preschoolers with Autism Spectrum Disorder and Hyperlexia

Alleen toegankelijk voor geautoriseerde gebruikers

American Psychiatric Association (APA). (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th ed. American Psychiatric Association. Retrieved April 4, 2020, from https://www.psychiatry.org/psychiatrists/practice/dsm

Andersen, H. R., Debes, F., Wohlfahrt-Veje, C., Murata, K., & Grandjean, P. (2015). Occupational pesticide exposure in early pregnancy associated with sex-specific neurobehavioral deficits in the children at school age. Neurotoxicology and Teratology, 47, 1–9. https://doi.org/10.1016/j.ntt.2014.10.006CrossRefPubMed

Bachelet, D., Truong, T., Verner, M.-A., Arveux, P., Kerbrat, P., Charlier, C., Guihenneuc-Jouyaux, C., & Guénel, P. (2011). Determinants of serum concentrations of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls among French women in the CECILE study. Environmental Research, 111, 861–870. https://doi.org/10.1016/j.envres.2011.06.001CrossRefPubMed

Baxter, A. J., Brugha, T. S., Erskine, H. E., Scheurer, R. W., Vos, T., & Scott, J. G. (2015). The epidemiology and global burden of autism spectrum disorders. Psychological Medicine, 45, 601–613. https://doi.org/10.1017/s003329171400172xCrossRefPubMed

Begg, C. B., & Mazumdar, M. (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088–1101CrossRefPubMed

Bigbee, J. W., Sharma, K. V., Chan, E. L. P., & Bögler, O. (2000). Evidence for the direct role of acetylcholinesterase in neurite outgrowth in primary dorsal root ganglion neurons. Brain Research, 861, 354–362. https://doi.org/10.1016/S0006-8993(00)02046-1CrossRefPubMed

Bjørklund, G., Meguid, N. A., El-Bana, M. A., Tinkov, A. A., Saad, K., Dadar, M., Hemimi, M., Skalny, A. V., Hosnedlová, B., Kizek, R., Osredkar, J., Urbina, M. A., Fabjan, T., El-Houfey, A. A., Kałużna-Czaplińska, J., Gątarek, P., & Chirumbolo, S. (2020). Oxidative stress in autism spectrum disorder. Molecular Neurobiology. https://doi.org/10.1007/s12035-019-01742-2CrossRefPubMedPubMedCentral

Bradman, A., Barr, D. B., Claus Henn, B. G., Drumheller, T., Curry, C., & Eskenazi, B. (2003). Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: A validation study. Environmental Health Perspectives, 111, 1779–1782. https://doi.org/10.1289/ehp.6259CrossRefPubMedPubMedCentral

Brown, A. S., Cheslack-Postava, K., Rantakokko, P., Kiviranta, H., Hinkka-Yli-Salomäki, S., McKeague, I. W., Surcel, H.-M., & Sourander, A. (2018). Association of maternal insecticide levels with autism in offspring from a national birth cohort. American Journal of Psychiatry, 175, 1094–1101. https://doi.org/10.1176/appi.ajp.2018.17101129CrossRefPubMed

Burdorf, A., Brand, T., Jaddoe, V. W., Hofman, A., Mackenbach, J. P., & Steegers, E. A. P. (2011). The effects of work-related maternal risk factors on time to pregnancy, preterm birth and birth weight: The generation R study. Occupational and Environmental Medicine, 68, 197. https://doi.org/10.1136/oem.2009.046516CrossRefPubMed

Casida, J. E. (2009). Pest toxicology: The primary mechanisms of pesticide action. Chemical Research in Toxicology, 22, 609–619. https://doi.org/10.1021/tx8004949CrossRefPubMed

Cheslack-Postava, K., Rantakokko, P. V., Hinkka-Yli-Salomäki, S., Surcel, H.-M., McKeague, I. W., Kiviranta, H. A., Sourander, A., & Brown, A. S. (2013). Maternal serum persistent organic pollutants in the finnish prenatal study of autism: A pilot study. Neurotoxicology and Teratology, 38, 1–5. https://doi.org/10.1016/j.ntt.2013.04.001CrossRefPubMedPubMedCentral

Christian, M. A., Samms-Vaughan, M., Lee, M., Bressler, J., Hessabi, M., Grove, M. L., Shakespeare-Pellington, S., Desai, C. C., Reece, J.-A., Loveland, K. A., Boerwinkle, E., & Rahbar, M. H. (2018). Maternal exposures associated with autism spectrum disorder in Jamaican children. Journal of Autism and Developmental Disorders, 48, 2766–2778. https://doi.org/10.1007/s10803-018-3537-6CrossRefPubMedPubMedCentral

de Bildt, A., Sytema, S., Ketelaars, C., Kraijer, D., Mulder, E., Volkmar, F., & Minderaa, R. (2004). Interrelationship between autism diagnostic observation schedule-generic (ADOS-G), autism diagnostic interview-revised (ADI-R), and the diagnostic and statistical manual of mental disorders (DSM-IV-TR) classification in children and adolescents with mental retardation. Journal of Autism and Developmental Disorders, 34, 129–137. https://doi.org/10.1023/B:JADD.0000022604.22374.5fCrossRefPubMed

De Felice, A., Scattoni, M. L., Ricceri, L., & Calamandrei, G. (2015). Prenatal exposure to a common organophosphate insecticide delays motor development in a mouse model of idiopathic autism. PLoS ONE, 10, e0121663. https://doi.org/10.1371/journal.pone.0121663CrossRefPubMedPubMedCentral

Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629. https://doi.org/10.1136/bmj.315.7109.629CrossRefPubMedPubMedCentral

Eskenazi, B., Marks, A. R., Bradman, A., Harley, K., Barr, D. B., Johnson, C., Morga, N., & Jewell, N. P. (2007). Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environmental health perspectives, 115, 792–8. https://doi.org/10.1289/ehp.9828CrossRefPubMedPubMedCentral

Evangelou, E., Ntritsos, G., Chondrogiorgi, M., Kavvoura, F. K., Hernández, A. F., Ntzani, E. E., & Tzoulaki, I. (2016). Exposure to pesticides and diabetes: A systematic review and meta-analysis. Environment International, 91, 60–68. https://doi.org/10.1016/j.envint.2016.02.013CrossRefPubMed

Furlong, M. A., Engel, S. M., Barr, D. B., & Wolff, M. S. (2014). Prenatal exposure to organophosphate pesticides and reciprocal social behavior in childhood. Environment International, 70, 125–131. https://doi.org/10.1016/j.envint.2014.05.011CrossRefPubMedPubMedCentral

Gray, L. E., Jr., & Ostby, J. (1998). Effects of pesticides and toxic substances on behavioral and morphological reproductive development: Endocrine versus nonendocrine mechanisms. Toxicology and Industrial Health, 14, 159–184. https://doi.org/10.1177/074823379801400111CrossRefPubMed

Hamra, G. B., Lyall, K., Windham, G. C., Calafat, A. M., Sjödin, A., Volk, H., & Croen, L. A. (2019). Prenatal exposure to endocrine-disrupting chemicals in relation to autism spectrum disorder and intellectual disability. Epidemiology (Cambridge, Mass), 30, 418–426. https://doi.org/10.1097/ede.0000000000000983CrossRef

Higgins, J. P., & Thompson, S. G. (2002). Quantifying heterogeneity in a meta-analysis. Statistics in Medicine, 21, 1539–1558. https://doi.org/10.1002/sim.1186CrossRefPubMed

Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557. https://doi.org/10.1136/bmj.327.7414.557CrossRefPubMedPubMedCentral

Keil, A. P., Daniels, J. L., & Hertz-Picciotto, I. (2014). Autism spectrum disorder, flea and tick medication, and adjustments for exposure misclassification: The CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Environmental Health : A Global Access Science Source, 13, 3. https://doi.org/10.1186/1476-069x-13-3CrossRef

Landrigan, P. (2017). Pesticides and human reproduction. JAMA Internal Medicine. https://doi.org/10.1001/jamainternmed.2017.5092CrossRef

Lee, D.-H., Lind, L., Jacobs, D. R., Salihovic, S., van Bavel, B., & Lind, P. M. (2012). Associations of persistent organic pollutants with abdominal obesity in the elderly: The prospective investigation of the vasculature in uppsala seniors (PIVUS) study. Environment International, 40, 170–178. https://doi.org/10.1016/j.envint.2011.07.010CrossRefPubMed

Lee, I., Eriksson, P., Fredriksson, A., Buratovic, S., & Viberg, H. (2015). Developmental neurotoxic effects of two pesticides: Behavior and neuroprotein studies on endosulfan and cypermethrin. Toxicology, 335, 1–10. https://doi.org/10.1016/j.tox.2015.06.010CrossRefPubMed

Lord, C., Brugha, T. S., Charman, T., Cusack, J., Dumas, G., Frazier, T., Jones, E. J. H., Jones, R. M., Pickles, A., State, M. W., Taylor, J. L., & Veenstra-VanderWeele, J. (2020). Autism spectrum disorder. Nature Reviews Disease Primers, 6, 5. https://doi.org/10.1038/s41572-019-0138-4CrossRefPubMedPubMedCentral

Lu, C., Bravo, R., Caltabiano, L. M., Irish, R. M., Weerasekera, G., & Barr, D. B. (2005). The presence of dialkylphosphates in fresh fruit juices: Implication for organophosphorus pesticide exposure and risk assessments. Journal of Toxicology and Environmental Health, Part A, 68, 209–227. https://doi.org/10.1080/15287390590890554CrossRef

Lyall, K., Croen, L. A., Sjödin, A., Yoshida, C. K., Zerbo, O., Kharrazi, M., & Windham, G. C. (2017). Polychlorinated biphenyl and organochlorine pesticide concentrations in maternal mid-pregnancy serum samples: Association with autism spectrum disorder and intellectual disability. Environmental Health Perspectives, 125, 474–480. https://doi.org/10.1289/EHP277CrossRefPubMed

Morales, D. R., Slattery, J., Evans, S., & Kurz, X. (2018). Antidepressant use during pregnancy and risk of autism spectrum disorder and attention deficit hyperactivity disorder: Systematic review of observational studies and methodological considerations. BMC Medicine, 16, 6. https://doi.org/10.1186/s12916-017-0993-3CrossRefPubMedPubMedCentral

Mostafalou, S., & Abdollahi, M. (2017). Pesticides: An update of human exposure and toxicity. Archives of Toxicology, 91, 549–599. https://doi.org/10.1007/s00204-016-1849-xCrossRefPubMed

World Health Organization. (2019). Fact sheet, autism spectrum disorders. World Health Organization, Retrieved April 4, 2020, from https://www.who.int/news-room/fact-sheets/detail/autism-spectrum-disorders

Pang, Y., Lee, C. M., Wright, M., Shen, J., Shen, B., & Bo, J. (2018). Challenges of case identification and diagnosis of autism spectrum disorders in China: A critical review of procedures, assessment, and diagnostic criteria. Research in Autism Spectrum Disorders, 53, 53–66. https://doi.org/10.1016/j.rasd.2018.06.003CrossRef

Pearson, B. L., Simon, J. M., McCoy, E. S., Salazar, G., Fragola, G., & Zylka, M. J. (2016). Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. Nature Communications, 7, 11173. https://doi.org/10.1038/ncomms11173CrossRefPubMedPubMedCentral

Philippat, C., Barkoski, J., Tancredi, D. J., Elms, B., Barr, D. B., Ozonoff, S., Bennett, D. H., & Hertz-Picciotto, I. (2018). Prenatal exposure to organophosphate pesticides and risk of autism spectrum disorders and other non-typical development at 3 years in a high-risk cohort. International Journal of Hygiene and Environmental Health, 221, 548–555. https://doi.org/10.1016/j.ijheh.2018.02.004CrossRefPubMedPubMedCentral

Roberts Eric, M., English Paul, B., Grether Judith, K., Windham Gayle, C., Somberg, L., & Wolff, C. (2007). Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the california central valley. Environmental Health Perspectives, 115, 1482–1489. https://doi.org/10.1289/ehp.10168CrossRefPubMedPubMedCentral

Ruediger, T., & Bolz, J. (2007). Neurotransmitters and the development of neuronal circuits. Advances in Experimental Medicine and Biology, 621, 104–115. https://doi.org/10.1007/978-0-387-76715-4_8CrossRefPubMed

Sagiv, S. K., Harris, M. H., Gunier, R. B., Kogut, K. R., Harley, K. G., Deardorff, J., Bradman, A., Holland, N., & Eskenazi, B. (2018). Prenatal organophosphate pesticide exposure and traits related to autism spectrum disorders in a population living in proximity to agriculture. Environmental Health Perspectives, 126, 047012. https://doi.org/10.1289/ehp2580CrossRefPubMedPubMedCentral

Sandin, S., Hultman, C. M., Kolevzon, A., Gross, R., MacCabe, J. H., & Reichenberg, A. (2012). Advancing maternal age is associated with increasing risk for autism: A review and meta-analysis. Journal of the American Academy of Child & Adolescent Psychiatry, 51, 477-486.e1. https://doi.org/10.1016/j.jaac.2012.02.018CrossRef

Schmidt, R. J., Kogan, V., Shelton, J. F., Delwiche, L., Hansen, R. L., Ozonoff, S., Ma, C. C., McCanlies, E. C., Bennett, D. H., Hertz-Picciotto, I., Tancredi, D. J., & Volk, H. E. (2017). Combined prenatal pesticide exposure and folic acid intake in relation to autism spectrum disorder. Environmental Health Perspectives, 125, 097007. https://doi.org/10.1289/ehp604CrossRefPubMedPubMedCentral

Shelton, J. F., Geraghty, E. M., Tancredi, D. J., Delwiche, L. D., Schmidt, R. J., Ritz, B., Hansen, R. L., & Hertz-Picciotto, I. (2014). Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides: The CHARGE study. Environmental Health Perspectives, 122, 1103–1109. https://doi.org/10.1289/ehp.1307044CrossRefPubMedPubMedCentral

Stroup, D. F., Berlin, J. A., Morton, S. C., Olkin, I., Williamson, G. D., Rennie, D., Moher, D., Becker, B. J., Sipe, T. A., & Thacker, S. B. (2000). Meta-analysis of observational studies in epidemiology: A proposal for reporting. JAMA, 283, 2008–2012. https://doi.org/10.1001/jama.283.15.2008CrossRefPubMed

Topal, A., Alak, G., Ozkaraca, M., Yeltekin, A. C., Comaklı, S., Acıl, G., Kokturk, M., & Atamanalp, M. (2017). Neurotoxic responses in brain tissues of rainbow trout exposed to imidacloprid pesticide: Assessment of 8-hydroxy-2-deoxyguanosine activity, oxidative stress and acetylcholinesterase activity. Chemosphere, 175, 186–191. https://doi.org/10.1016/j.chemosphere.2017.02.047CrossRefPubMed

Viel, J.-F., Rouget, F., Warembourg, C., Monfort, C., Limon, G., Cordier, S., & Chevrier, C. (2017). Behavioural disorders in 6-year-old children and pyrethroid insecticide exposure: The PELAGIE mother-child cohort. Occupational and Environmental Medicine, 74, 275–281. https://doi.org/10.1136/oemed-2016-104035CrossRefPubMed

von Ehrenstein, O. S., Ling, C., Cui, X., Cockburn, M., Park, A. S., Yu, F., Wu, J., & Ritz, B. (2019). Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: Population based case-control study. BMJ, 364, l962. https://doi.org/10.1136/bmj.l962CrossRef

Wang, Y., Tang, S., Xu, S., Weng, S., & Liu, Z. (2016). Maternal body mass index and risk of autism spectrum disorders in offspring: A meta-analysis. Scientific Reports, 6, 34248. https://doi.org/10.1038/srep34248CrossRefPubMedPubMedCentral

Wells, G. A., O’Connell, B. S. D., Peterson, J., Welch, V., Losos, M., & Tugwell, P. (2011). The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. The Ottawa Health Research Institute.

Xu, G., Jing, J., Bowers, K., Liu, B., & Bao, W. (2014). Maternal diabetes and the risk of autism spectrum disorders in the offspring: A systematic review and meta-analysis. Journal of Autism and Developmental Disorders, 44, 766–775. https://doi.org/10.1007/s10803-013-1928-2CrossRefPubMedPubMedCentral

Zhu, Z., Tang, S., Deng, X., & Wang, Y. (2020). Maternal systemic lupus erythematosus, rheumatoid arthritis, and risk for autism spectrum disorders in offspring: A meta-analysis. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-020-04400-yCrossRefPubMed

Titel: Maternal Exposure to Pesticides and Risk of Autism Spectrum Disorders in Offspring: A Meta-analysis
Auteurs: Li Wang
Shiming Tang
Songjie Wu
Lihua Yao
Dezhen Su
Ying Wang
Publicatiedatum: 12-05-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 4/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05063-z

Andere artikelen Uitgave 4/2022

Dysregulation in Children and Adolescents Presenting to a Multidisciplinary Autism Clinic

Original Paper

Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis

Open Access
Original Paper

Brief Report: Examining the Links Between Language Processes and Working Memory Impairments in Toddlers and Preschoolers with ASD

Brief Report

Correction to: Community Participation Comparison Between Adults on the Autism Spectrum and Adults in the General Population

Correction

The Association of the Medicaid 1915(c) Home and Community-Based Services Waivers with Emergency Department Utilization among Youth with Autism Spectrum Disorder

Original Paper

The Role of Acceptance in the Transition to Adulthood: A Multi-Informant Comparison of Practitioners, Families, and Youth with Autism

Original Paper