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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-04-2014 | Original Paper

Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis

Auteurs: Guifeng Xu, Jin Jing, Katherine Bowers, Buyun Liu, Wei Bao

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2014

Abstract

We performed a systematic literature search regarding maternal diabetes before and during pregnancy and the risk of autism spectrum disorders (ASD) in the offspring. Of the 178 potentially relevant articles, 12 articles including three cohort studies and nine case–control studies were included in the meta-analysis. Both the meta-analyses of cohort studies and case–control studies showed significant associations. The pooled relative risk and 95 % confidence interval (CI) among cohort studies was 1.48 (1.25–1.75, p < 0.001). For case–control studies, the pooled odds ratio and 95 % CI was 1.72 (1.24–2.41, p = 0.001). No indication of significant heterogeneity across studies or publication bias was observed. In conclusion, maternal diabetes was significantly associated with a greater risk of ASD in the offspring.

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Albrecht, S. S., Kuklina, E. V., Bansil, P., Jamieson, D. J., Whiteman, M. K., Kourtis, A. P., et al. (2010). Diabetes trends among delivery hospitalizations in the US, 1994–2004. Diabetes Care, 33, 768–773.PubMedCentralPubMedCrossRef

American Diabetes Association. (2004). Gestational diabetes mellitus. Diabetes Care, 27(Suppl 1), S88–S90.

American Diabetes Association. (2013). Diagnosis and classification of diabetes mellitus. Diabetes Care, 36(Suppl 1), S67–S74.PubMedCentralCrossRef

Anderson, J. L., Waller, D. K., Canfield, M. A., Shaw, G. M., Watkins, M. L., & Werler, M. M. (2005). Maternal obesity, gestational diabetes, and central nervous system birth defects. Epidemiology, 16, 87–92.PubMedCrossRef

Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators; Centers for Disease Control and Prevention. (2012). Prevalence of autism spectrum disorders–Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveill Summ, 61, 1–19.

Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., et al. (1995). Autism as a strongly genetic disorder: evidence from a British twin study. Psychological Medicine, 25, 63–77.PubMedCrossRef

Bardenheier, B. H., Elixhauser, A., Imperatore, G., Devlin, H. M., Kuklina, E. V., Geiss, L. S., et al. (2013). Variation in prevalence of gestational diabetes mellitus among hospital discharges for obstetric delivery across 23 states in the United States. Diabetes Care, 36, 1209–1214.PubMedCrossRef

Bell, R., Bailey, K., Cresswell, T., Hawthorne, G., Critchley, J., & Lewis-Barned, N. (2008). Trends in prevalence and outcomes of pregnancy in women with pre-existing type I and type II diabetes. BJOG: An International Journal of Obstetrics and Gynaecology, 115, 445–452.CrossRef

Biri, A., Onan, A., Devrim, E., Babacan, F., Kavutcu, M., & Durak, I. (2006). Oxidant status in maternal and cord plasma and placental tissue in gestational diabetes. Placenta, 27, 327–332.PubMedCrossRef

Brimacombe, M., Ming, X., & Lamendola, M. (2007). Prenatal and birth complications in autism. Maternal and Child Health Journal, 11, 73–79.PubMedCrossRef

Buchmayer, S., Johansson, S., Johansson, A., Hultman, C. M., Sparen, P., & Cnattingius, S. (2009). Can association between preterm birth and autism be explained by maternal or neonatal morbidity? Pediatrics, 124, e817–e825.PubMedCrossRef

Burstyn, I., Sithole, F., & Zwaigenbaum, L. (2010). Autism spectrum disorders, maternal characteristics and obstetric complications among singletons born in Alberta, Canada. Chronic Diseases in Canada, 30, 125–134.PubMed

Burstyn, I., Wang, X., Yasui, Y., Sithole, F., & Zwaigenbaum, L. (2011). Autism spectrum disorders and fetal hypoxia in a population-based cohort: accounting for missing exposures via Estimation-Maximization algorithm. BMC Medical Research Methodology, 11, 2.PubMedCentralPubMedCrossRef

Chauhan, A., Chauhan, V., Brown, W. T., & Cohen, I. (2004). Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin–the antioxidant proteins. Life Sciences, 75, 2539–2549.PubMedCrossRef

Chen, X., & Scholl, T. O. (2005). Oxidative stress: Changes in pregnancy and with gestational diabetes mellitus. Current Diabetes Reports, 5, 282–288.PubMedCrossRef

Croen, L. A., Grether, J. K., Yoshida, C. K., Odouli, R., & Van de Water, J. (2005). Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: A case-control study. Archives of Pediatrics and Adolescent Medicine, 159, 151–157.PubMedCrossRef

DerSimonian, R., & Laird, N. (1986). Meta-analysis in clinical trials. Controlled Clinical Trials, 7, 177–188.PubMedCrossRef

Dodds, L., Fell, D. B., Shea, S., Armson, B. A., Allen, A. C., & Bryson, S. (2011). The role of prenatal, obstetric and neonatal factors in the development of autism. Journal of Autism and Developmental Disorders, 41, 891–902.PubMedCrossRef

Egger, M., Davey Smith, G., Schneider, M., & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629–634.PubMedCentralPubMedCrossRef

Eidelman, A. I., & Samueloff, A. (2002). The pathophysiology of the fetus of the diabetic mother. Seminars in Perinatology, 26, 232–236.PubMedCrossRef

Elhameed, M. A. A., Elbaky, A. E. O. A., & Kamel, E. A. (2011). A controlled study of the risk factors and clinical picture of children with autism in an Egyptian sample. Egypt Journal of Neurology, Neurosurgery and Psychiatry, 48, 271–276.

Fernandez-Morera, J. L., Rodriguez-Rodero, S., Menendez-Torre, E., & Fraga, M. F. (2010). The possible role of epigenetics in gestational diabetes: Cause, consequence, or both. Obstetrics and Gynecology International, 2010, 605163.PubMedCentralPubMedCrossRef

Ferrara, A. (2007). Increasing prevalence of gestational diabetes mellitus: A public health perspective. Diabetes Care, 30(Suppl 2), S141–S146.PubMedCrossRef

Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal risk factors for autism: Comprehensive meta-analysis. British Journal of Psychiatry, 195, 7–14.PubMedCentralPubMedCrossRef

Gardener, H., Spiegelman, D., & Buka, S. L. (2011). Perinatal and neonatal risk factors for autism: A comprehensive meta-analysis. Pediatrics, 128, 344–355.PubMedCentralPubMedCrossRef

Georgieff, M. K. (2006). The effect of maternal diabetes during pregnancy on the neurodevelopment of offspring. Minnesota Medicine, 89, 44–47.PubMed

Gillberg, C. (1999). Neurodevelopmental processes and psychological functioning in autism. Development and Psychopathology, 11, 567–587.PubMedCrossRef

Guinchat, V., Thorsen, P., Laurent, C., Cans, C., Bodeau, N., & Cohen, D. (2012). Pre-, peri- and neonatal risk factors for autism. Acta Obstetricia et Gynecologica Scandinavica, 91, 287–300.PubMedCrossRef

Hayes, D. K., Fan, A. Z., Smith, R. A., & Bombard, J. M. (2011). Trends in selected chronic conditions and behavioral risk factors among women of reproductive age, behavioral risk factor surveillance system, 2001–2009. Preventing Chronic Disease, 8, A120.PubMedCentralPubMed

Herrera, E., & Ortega-Senovilla, H. (2010). Disturbances in lipid metabolism in diabetic pregnancy: Are these the cause of the problem? Best Practice and Research Clinical Endocrinology and Metabolism, 24, 515–525.PubMedCrossRef

Higgins, J. P., & Thompson, S. G. (2002). Quantifying heterogeneity in a meta-analysis. Statistics in Medicine, 21, 1539–1558.PubMedCrossRef

Huerta, J. M., Tormo, M. J., Egea-Caparros, J. M., Ortola-Devesa, J. B., & Navarro, C. (2009). Accuracy of self-reported diabetes, hypertension and hyperlipidemia in the adult Spanish population. DINO study findings. Revista Espanola de Cardiologia, 62, 143–152.PubMedCrossRef

Hultman, C. M., Sparen, P., & Cnattingius, S. (2002). Perinatal risk factors for infantile autism. Epidemiology, 13, 417–423.PubMedCrossRef

International Diabetes Federation. (2013) IDF Policy Briefing: Diabetes in Pregnancy: Protecting Maternal Health. Accessed July 10, 2013, from http://www.idf.org/sites/default/files/Policy_Briefing_DiabetesInPregancy.pdf.

Juul-Dam, N., Townsend, J., & Courchesne, E. (2001). Prenatal, perinatal, and neonatal factors in autism, pervasive developmental disorder-not otherwise specified, and the general population. Pediatrics, 107, E63.PubMedCrossRef

Keil, A., Daniels, J. L., Forssen, U., Hultman, C., Cnattingius, S., Soderberg, K. C., et al. (2010). Parental autoimmune diseases associated with autism spectrum disorders in offspring. Epidemiology, 21, 805–808.PubMedCentralPubMedCrossRef

Kolevzon, A., Gross, R., & Reichenberg, A. (2007). Prenatal and perinatal risk factors for autism: a review and integration of findings. Archives of Pediatrics and Adolescent Medicine, 161, 326–333.PubMedCrossRef

Krakowiak, P., Walker, C. K., Bremer, A. A., Baker, A. S., Ozonoff, S., Hansen, R. L., et al. (2012). Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics, 129, e1121–e1128.PubMedCentralPubMedCrossRef

Leonard, H., de Klerk, N., Bourke, J., & Bower, C. (2006). Maternal health in pregnancy and intellectual disability in the offspring: A population-based study. Annals of Epidemiology, 16, 448–454.PubMedCrossRef

Levy, S. E., Mandell, D. S., & Schultz, R. T. (2009). Autism. Lancet, 374, 1627–1638.CrossRef

London, E. A. (2000). The environment as an etiologic factor in autism: A new direction for research. Environmental Health Perspectives, 108(Suppl 3), 401–404.PubMedCentralPubMed

Lyall, K., Pauls, D. L., Spiegelman, D., Ascherio, A., & Santangelo, S. L. (2012). Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the Nurses’ Health Study II. Autism Research, 5, 21–30.PubMedCentralPubMedCrossRef

Ming, X., Stein, T. P., Brimacombe, M., Johnson, W. G., Lambert, G. H., & Wagner, G. C. (2005). Increased excretion of a lipid peroxidation biomarker in autism. Prostaglandins Leukotrienes and Essential Fatty Acids, 73, 379–384.CrossRef

National Institute for Health and Care Excellence. (2009). NICE clinical guidelines 63: Diabetes in pregnancy: Management of diabetes and its complications from pre-conception to the postnatal period. Accessed July 10, 2013, from http://guidance.nice.org.uk/CG63.

Newschaffer, C. J., Croen, L. A., Daniels, J., Giarelli, E., Grether, J. K., Levy, S. E., et al. (2007). The epidemiology of autism spectrum disorders. Annual Review of Public Health, 28, 235–258.PubMedCrossRef

Okura, Y., Urban, L. H., Mahoney, D. W., Jacobsen, S. J., & Rodeheffer, R. J. (2004). Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure. Journal of Clinical Epidemiology, 57, 1096–1103.PubMedCrossRef

Onore, C., Careaga, M., & Ashwood, P. (2012). The role of immune dysfunction in the pathophysiology of autism. Brain, Behavior, and Immunity, 26, 383–392.PubMedCentralPubMedCrossRef

Ornoy, A., Ratzon, N., Greenbaum, C., Wolf, A., & Dulitzky, M. (2001). School-age children born to diabetic mothers and to mothers with gestational diabetes exhibit a high rate of inattention and fine and gross motor impairment. Journal of Pediatric Endocrinology and Metabolism, 14(Suppl 1), 681–689.PubMed

Piven, J., Simon, J., Chase, G. A., Wzorek, M., Landa, R., Gayle, J., et al. (1993). The etiology of autism: Pre-, peri- and neonatal factors. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 1256–1263.PubMedCrossRef

Rapin, I. (2002). The autistic-spectrum disorders. New England Journal of Medicine, 347, 302–303.PubMedCrossRef

Rizzo, T. A., Dooley, S. L., Metzger, B. E., Cho, N. H., Ogata, E. S., & Silverman, B. L. (1995). Prenatal and perinatal influences on long-term psychomotor development in offspring of diabetic mothers. American Journal of Obstetrics and Gynecology, 173, 1753–1758.PubMedCrossRef

Rodier, P. M., Ingram, J. L., Tisdale, B., Nelson, S., & Romano, J. (1996). Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei. Journal of Comparative Neurology, 370, 247–261.PubMedCrossRef

Schanen, N. C. (2006). Epigenetics of autism spectrum disorders. Hum Mol Genet, 15(2), R138–R150.PubMedCrossRef

Solomon, C. G., Willett, W. C., Carey, V. J., Rich-Edwards, J., Hunter, D. J., Colditz, G. A., et al. (1997). A prospective study of pregravid determinants of gestational diabetes mellitus. The Journal of the American Medical Association, 278, 1078–1083.CrossRef

Stern, M. (2011). Insulin signaling and autism. Frontiers in Endocrinology, 2, 54.PubMedCentralPubMedCrossRef

Stroup, D. F., Berlin, J. A., Morton, S. C., Olkin, I., Williamson, G. D., Rennie, D., et al. (2000). Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. The Journal of the American Medical Association, 283, 2008–2012.CrossRef

Van den Bergh, B. R. (2011). Developmental programming of early brain and behaviour development and mental health: a conceptual framework. Developmental Medicine and Child Neurology, 53(Suppl 4), 19–23.PubMedCrossRef

Wells, G. A., Shea, B., O’Connell, D., Peterson, J., Welch, V., Losos, M., et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. Accessed January 30, 2013, from http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm.

Wong, V. C., & Hui, S. L. (2008). Epidemiological study of autism spectrum disorder in China. Journal of Child Neurology, 23, 67–72.PubMedCrossRef

Yao, Y., Walsh, W. J., McGinnis, W. R., & Pratico, D. (2006). Altered vascular phenotype in autism: correlation with oxidative stress. Archives of Neurology, 63, 1161–1164.PubMedCrossRef

Titel: Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis
Auteurs: Guifeng Xu
Jin Jing
Katherine Bowers
Buyun Liu
Wei Bao
Publicatiedatum: 01-04-2014
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 4/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-013-1928-2

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