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19-11-2019

Mapping PedsQLTM scores onto CHU9D utility scores: estimation, validation and a comparison of alternative instrument versions

Auteurs: Rohan Sweeney, Gang Chen, Lisa Gold, Fiona Mensah, Melissa Wake

Gepubliceerd in: Quality of Life Research | Uitgave 3/2020

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Abstract

Background

The Paediatric Quality of Life InventoryTM 4.0 Generic Core Scales (PedsQL) is a non-preference based instrument for assessing health related quality of life (HRQoL) in children. Recent papers presented algorithms of parental proxy and short-form versions of the PedsQL onto the validated preference-based Child Health Utility 9D (CHU9D) instrument, to enable conversion of PedsQL scores to quality adjusted life years for use in economic evaluation. However, further research was needed to both validate these algorithms, and assess if use of the full 23-item PedsQL self-report instrument is preferable to other PedsQL versions for mapping onto child self-report CHU9D utilities.

Objective

To develop a mapping algorithm for converting the 23-item PedsQL instrument onto the CHU9D instrument and provide an external validation of two recently published algorithms that might be considered alternatives.

Methods

Data from children in the Longitudinal Study of Australian Children (LSAC) were used (N = 1801). Six econometric methods were compared to identify the best algorithms, assessed against a series of goodness-of-fit criteria. The same data and goodness-of-fit criteria were used in the external validation exercise for previously published mapping algorithms.

Results

The optimal mapping algorithm was identified, which used PedsQL dimension scores to predict the CHU9D utilities. It performed well against standard goodness-of-fit tests. The external validation exercise revealed the recently published alternative algorithms also performed relatively well.

Conclusion

The identified mapping algorithms can be used to facilitate cost-utility analysis in comparable populations when only the PedsQL instrument is available. Results from this population indicate the algorithms identified in this paper are well suited for estimating CHU9D self-report utilities when the full 23-item self-report PedsQL instrument has been used.
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Voetnoten
1
Whilst the need for a representative Australian sample is not applicable in this analysis, survey weights are available for research investigations that do have that requirement.
 
2
The 23 item PedsQL instrument enables calculation of overall and dimension-level scores even when some individual questions/items have not been answered (see https://​www.​pedsql.​org/​score.​html).
 
3
Note that we initially also considered the beta mixture regression proposed by Gray and Hernández-Alava [23]; however, the single class beta regression was found to perform better than latent class regressions for each model-level, as such the beta mixture regression results were omitted. The multivariable fractional polynomials (MFP) regression approach (which was estimated using a robust regression model) was also initially investigated for inclusion as a seventh econometric estimation method. However, it was ruled out for inclusion as it was found to be unstable in Model 2 validations, producing a lower bound estimate of − 0.4825 CHU9D utility score in the validation exercise (further MFP results are available upon request).
 
4
Overall 26.2% children reported any medical condition. The most commonly reported condition was asthma (reported by 13.5% children); others include allergy, blood clotting condition, bone disorder, broken bone(s) that are still healing, chronic or recurring pain/discomfort, diabetes, difficulty gripping or holding things, hearing loss, incomplete use of arms/fingers/feet/legs, infection or injury to toes/toenails, mental illnesses, restriction in physical activities, shortness of breath causing restriction and vision loss.
 
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Metagegevens
Titel
Mapping PedsQLTM scores onto CHU9D utility scores: estimation, validation and a comparison of alternative instrument versions
Auteurs
Rohan Sweeney
Gang Chen
Lisa Gold
Fiona Mensah
Melissa Wake
Publicatiedatum
19-11-2019
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 3/2020
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-019-02357-9