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Gepubliceerd in:

01-04-2016

Mapping chronic liver disease questionnaire scores onto SF-6D utility values in patients with primary sclerosing cholangitis

Auteurs: Evangelos Kalaitzakis, Maria Benito de Valle, Monira Rahman, Björn Lindkvist, Einar Björnsson, Roger Chapman, Nick Kontodimopoulos

Gepubliceerd in: Quality of Life Research | Uitgave 4/2016

Abstract

Purpose

The chronic liver disease questionnaire (CLDQ) is a frequently used liver-specific quality of life instrument, but it does not provide information on preference-adjusted health status, which is essential for cost-utility analysis. We aimed to develop a mapping function deriving utilities from the CLDQ in primary sclerosing cholangitis (PSC).

Methods

Short form-6D (SF-6D) utilities were calculated from SF-36 data collected in a recent prospective study in which unselected patients with PSC also completed the CLDQ. Ordinary least squares (OLS), generalized linear, median, and kernel regression analyses were employed to devise a mapping function predicting utilities. This was validated in three random subsamples of the cohort and in a separate sample of PSC patients following liver transplantation. Adjusted R ² and root-mean-square error (RMSE) as well as Pearson’s r coefficients and mean absolute errors between predicted and observed values were used to determine model performance.

Results

Decompensated liver disease and fatigue, systemic symptoms, and emotional distress, assessed with the CLDQ, were related to worse SF-6D utilities. The final OLS prediction model explained 66.3 % of the variance in the derivation sample. Predicted and observed utilities were strongly correlated (r = 0.807, p < 0.001), but the mean absolute error (0.0604) and adjusted RMSE (10.6 %) were of intermediate size. Similar model characteristics were observed after employment of generalized linear and median regression models and at validation.

Conclusions

A model has been constructed, showing good validity predicting SF-6D utilities from CLDQ scores at the group level in PSC. Further testing is required to externally validate the model.

vorige artikel Generic and disease-specific estimates of quality of life in macular degeneration: mapping the MacDQoL onto the EQ-5D-3L

volgende artikel Perceived family functioning, adolescent psychopathology and quality of life in the general population: a 6-month follow-up study

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Titel: Mapping chronic liver disease questionnaire scores onto SF-6D utility values in patients with primary sclerosing cholangitis
Auteurs: Evangelos Kalaitzakis
Maria Benito de Valle
Monira Rahman
Björn Lindkvist
Einar Björnsson
Roger Chapman
Nick Kontodimopoulos
Publicatiedatum: 01-04-2016
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 4/2016
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-015-1161-x

Bohn Stafleu van Loghum

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Abstract

Purpose

Methods

Results

Conclusions

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