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Quality of Life Research
Gepubliceerd in: Quality of Life Research 1/2010

01-02-2010

Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire

Auteurs: Helen Dakin, Stavros Petrou, Mark Haggard, Sarah Benge, Ian Williamson

Gepubliceerd in: Quality of Life Research | Uitgave 1/2010

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Abstract

Purpose

To investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores.

Methods

A placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores.

Results

OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error: 0.134 with HL and 0.132 without; R 2: 0.63 with HL and 0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difficulties, predicted HL, age and sex also produced accurate predictions.

Conclusion

Regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME.
vorige artikel Caregiver education in Parkinson’s disease: formative evaluation of a standardized program in seven European countries
volgende artikel Health status utilities and the impact of pressure ulcers in long-term care residents in Ontario
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Metagegevens
Titel
Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire
Auteurs
Helen Dakin
Stavros Petrou
Mark Haggard
Sarah Benge
Ian Williamson
Publicatiedatum
01-02-2010
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 1/2010
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-009-9558-z

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