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Gepubliceerd in: Quality of Life Research 9/2014

01-11-2014 | Brief Communication

Longitudinal changes in health-related quality of life in normal glucose tolerance, prediabetes and type 2 diabetes: results from the KORA S4/F4 cohort study

Auteurs: Matthias Hunger, Rolf Holle, Christa Meisinger, Wolfgang Rathmann, Annette Peters, Michaela Schunk

Gepubliceerd in: Quality of Life Research | Uitgave 9/2014

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Abstract

Purpose

The aim of this study was to examine how transition between normal glucose tolerance, prediabetes and diabetes over a 7 year period is associated with change in health-related quality of life (HRQL) in an elder German population-based cohort.

Methods

We used data from 1,046 participants of the KORA S4/F4 cohort study aged 55–74 years at baseline. Based on an oral glucose tolerance test, prediabetes was defined as impaired fasting glucose and/or impaired glucose tolerance. HRQL was assessed with the SF-12 questionnaire. Using linear regression, we estimated mean change in HRQL over time, depending on glucose status at baseline and follow-up, adjusted by demographic and lifestyle variables.

Results

Individuals progressing to prediabetes or diabetes experienced a greater loss in the physical component score than patients with persistent normal glucose tolerance (−2.31 and −7.44 vs. −1.08), but the difference was only significant for subjects converting to diabetes. Subjects with prediabetes at baseline and diabetes at follow-up had a significant loss in mental health compared to subjects with persistent prediabetes.

Conclusions

There is first evidence that worsening of glucose metabolism over time is associated with deteriorating HRQL, however, further and larger longitudinal studies are needed to confirm these findings.
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Metagegevens
Titel
Longitudinal changes in health-related quality of life in normal glucose tolerance, prediabetes and type 2 diabetes: results from the KORA S4/F4 cohort study
Auteurs
Matthias Hunger
Rolf Holle
Christa Meisinger
Wolfgang Rathmann
Annette Peters
Michaela Schunk
Publicatiedatum
01-11-2014
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 9/2014
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-014-0689-5

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