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09-06-2016

Longitudinal assessment of health related quality of life of HIV infected patients treated for tuberculosis and HIV in a high burden setting

Auteurs: Thuli Mthiyane, Alex Pym, Keertan Dheda, Roxana Rustomjee, T. Reddy, Shamila Manie

Gepubliceerd in: Quality of Life Research | Uitgave 12/2016

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Abstract

Introduction

Assessment of patients receiving treatment for human immunodeficiency virus (HIV) and tuberculosis (TB) using a Health Related Quality of Life (HRQoL) instrument is important to get the subjective view of the patients’ wellbeing.

Methods

We used the Functional Assessment of HIV Infection (FAHI) HRQoL instrument to collect perceived wellness information at baseline, month 3, 6 and 12 from patients enrolled in a pharmacokinetic study between March 2007 and April 2008. Composite domain scores at each time point and their relationship with the rate of adverse events (AEs) and serious adverse events were compared between treatment arms.

Results

Out of the 82 patients enrolled, 76 were analysed. There was a significant increase in total score in all groups between baseline, month 3, 6 and 12 (all p values < 0.0001), and over time (p < 0.001). Adjusting for baseline total score, baseline CD4 count had a significant effect on the total score over time (p = 0.002) and the rate of change in total score over time, that is; interaction effect (p < 0.001). There was no difference in each domain scores between participants that received ART with TB treatment and those that received TB treatment only. Respiratory AEs had a significant effect on HRQoL.

Conclusion

We found that assessment of HRQoL of participants in TB–HIV treatment using the FAHI instrument was useful in evaluating treatment responses. It showed improvement consistent with decrease in adverse events and signs and symptoms of TB. Number and type of AEs was related to lower HRQoL in spite of TB cure.
Literatuur
1.
go back to reference Lorenz, K., et al. (2006). Changes in symptoms and health-related quality of life in a nationally representative sample of adults in treatment for HIV. Quality of Life Research, 15(6), 951–958.CrossRefPubMed Lorenz, K., et al. (2006). Changes in symptoms and health-related quality of life in a nationally representative sample of adults in treatment for HIV. Quality of Life Research, 15(6), 951–958.CrossRefPubMed
2.
go back to reference Kaplan, R. M., & Bush, J. W. (1982). Health-related quality of life measurement for evaluation research and policy analysis. Health Psychology, 1(1), 61.CrossRef Kaplan, R. M., & Bush, J. W. (1982). Health-related quality of life measurement for evaluation research and policy analysis. Health Psychology, 1(1), 61.CrossRef
3.
go back to reference Aggarwal, A. N., et al. (2013). Assessment of health-related quality of life in patients with pulmonary tuberculosis under programme conditions. The International Journal of Tuberculosis and Lung Disease, 17(7), 947–953.CrossRefPubMed Aggarwal, A. N., et al. (2013). Assessment of health-related quality of life in patients with pulmonary tuberculosis under programme conditions. The International Journal of Tuberculosis and Lung Disease, 17(7), 947–953.CrossRefPubMed
4.
go back to reference Mekasha, T. & Woldemichael, K. (2009). Assessment of patients’ health related quality of life during tuberculosis treatment as compared to their neighbours in Hawassa town, Ethiopia. Master’s thesis in public health. Mekasha, T. & Woldemichael, K. (2009). Assessment of patients’ health related quality of life during tuberculosis treatment as compared to their neighbours in Hawassa town, Ethiopia. Master’s thesis in public health.
5.
6.
go back to reference Duyan, B., et al. (2005). Relationship between quality of life and characteristics of patients hospitalized with tuberculosis. The International Journal of Tuberculosis and Lung Disease, 9(12), 1361–1366.PubMed Duyan, B., et al. (2005). Relationship between quality of life and characteristics of patients hospitalized with tuberculosis. The International Journal of Tuberculosis and Lung Disease, 9(12), 1361–1366.PubMed
7.
go back to reference Hansel, N., et al. (2004). Quality of life in tuberculosis: Patient and provider perspectives. Quality of Life Research, 13, 639–652.CrossRefPubMed Hansel, N., et al. (2004). Quality of life in tuberculosis: Patient and provider perspectives. Quality of Life Research, 13, 639–652.CrossRefPubMed
8.
go back to reference Guo, N., Marra, F., & Marra, C. (2009). Measuring health-related quality of life in tuberculosis: A systematic review. Health and Quality of Life Outcomes, 7(1), 14.CrossRefPubMedPubMedCentral Guo, N., Marra, F., & Marra, C. (2009). Measuring health-related quality of life in tuberculosis: A systematic review. Health and Quality of Life Outcomes, 7(1), 14.CrossRefPubMedPubMedCentral
9.
go back to reference Dhuria, M., Sharma, N., & Ingle, G. (2008). Impact of tuberculosis on the quality of life. Indian journal of community medicine: official publication of Indian Association of Preventive & Social Medicine, 33(1), 58.CrossRef Dhuria, M., Sharma, N., & Ingle, G. (2008). Impact of tuberculosis on the quality of life. Indian journal of community medicine: official publication of Indian Association of Preventive & Social Medicine, 33(1), 58.CrossRef
10.
go back to reference Kohli, R. M., et al. (2005). Assessment of quality of life among HIV-infected persons in Pune, India. Quality of life Research, 14(6), 1641–1647.CrossRefPubMed Kohli, R. M., et al. (2005). Assessment of quality of life among HIV-infected persons in Pune, India. Quality of life Research, 14(6), 1641–1647.CrossRefPubMed
11.
go back to reference Mutimura, E., Stewart, A., & Crowther, N. (2007). Assessment of quality of life in HAART-treated HIV-positive subjects with body fat redistribution in Rwanda. AIDS Research and Therapy, 4(19), 1–8. Mutimura, E., Stewart, A., & Crowther, N. (2007). Assessment of quality of life in HAART-treated HIV-positive subjects with body fat redistribution in Rwanda. AIDS Research and Therapy, 4(19), 1–8.
12.
go back to reference Murri, R., et al. (2003). Determinants of health-related quality of life in HIV-infected patients. AIDS Care, 15, 581–590.CrossRefPubMed Murri, R., et al. (2003). Determinants of health-related quality of life in HIV-infected patients. AIDS Care, 15, 581–590.CrossRefPubMed
13.
go back to reference Campsmith, M. L., Nakashima, A. K., & Davidson, A. J. (2003). Self-reported health-related quality of life in persons with HIV infection: Results from a multi-site interview project. Health Quality Life Outcomes, 1, 12.CrossRef Campsmith, M. L., Nakashima, A. K., & Davidson, A. J. (2003). Self-reported health-related quality of life in persons with HIV infection: Results from a multi-site interview project. Health Quality Life Outcomes, 1, 12.CrossRef
14.
go back to reference Gill, C. J., et al. (2002). Relationship of HIV viral loads, CD4 counts, and HAART use to health-related quality of life. Journal of acquired immune deficiency syndromes (1999), 30(5), 485–492.CrossRef Gill, C. J., et al. (2002). Relationship of HIV viral loads, CD4 counts, and HAART use to health-related quality of life. Journal of acquired immune deficiency syndromes (1999), 30(5), 485–492.CrossRef
15.
go back to reference McInerney, P. (2008). Quality of life and physical functioning in HIV-infected individuals receiving antiretroviral therapy in KwaZulu-Natal, South Africa. Nursing & Health Sciences, 10(4), 266–272.CrossRef McInerney, P. (2008). Quality of life and physical functioning in HIV-infected individuals receiving antiretroviral therapy in KwaZulu-Natal, South Africa. Nursing & Health Sciences, 10(4), 266–272.CrossRef
16.
go back to reference O’Keefe, E., & Wood, R. (1996). The impact of human immunodeficiency virus (HIV) infection on quality of life in a multiracial South African population. Quality of Life Research, 5(2), 275–280.CrossRefPubMed O’Keefe, E., & Wood, R. (1996). The impact of human immunodeficiency virus (HIV) infection on quality of life in a multiracial South African population. Quality of Life Research, 5(2), 275–280.CrossRefPubMed
17.
go back to reference Robberstad, B., & Olsen, J. (2010). The health related quality of life of people living with HIV/AIDS in sub-Saharan Africa—A literature review and focus group study. Cost Effectiveness and Resource Allocation, 8(1), 5.CrossRefPubMedPubMedCentral Robberstad, B., & Olsen, J. (2010). The health related quality of life of people living with HIV/AIDS in sub-Saharan Africa—A literature review and focus group study. Cost Effectiveness and Resource Allocation, 8(1), 5.CrossRefPubMedPubMedCentral
18.
go back to reference Deribew, A., et al. (2013). Change in quality of life: A follow up study among patients with HIV infection with and without TB in Ethiopia. BMC Public Health, 13(1), 408.CrossRefPubMedPubMedCentral Deribew, A., et al. (2013). Change in quality of life: A follow up study among patients with HIV infection with and without TB in Ethiopia. BMC Public Health, 13(1), 408.CrossRefPubMedPubMedCentral
19.
go back to reference Louw, J., et al. (2012). Quality of life among tuberculosis (TB), TB retreatment and/or TB–HIV co-infected primary public health care patients in three districts in South Africa. Health Quality Life Outcomes, 10(77), 1477–7525. Louw, J., et al. (2012). Quality of life among tuberculosis (TB), TB retreatment and/or TB–HIV co-infected primary public health care patients in three districts in South Africa. Health Quality Life Outcomes, 10(77), 1477–7525.
20.
go back to reference Dowdy, D. W., et al. (2013). Quality of life among people treated for tuberculosis and human immunodeficiency virus in Rio de Janeiro, Brazil. The International Journal of Tuberculosis and Lung Disease, 17(3), 345–347.CrossRefPubMedPubMedCentral Dowdy, D. W., et al. (2013). Quality of life among people treated for tuberculosis and human immunodeficiency virus in Rio de Janeiro, Brazil. The International Journal of Tuberculosis and Lung Disease, 17(3), 345–347.CrossRefPubMedPubMedCentral
21.
go back to reference World Health Organization. (2013). Global tuberculosis report 2013. Geneva, Switzerland: WHO, HTM/TB. World Health Organization. (2013). Global tuberculosis report 2013. Geneva, Switzerland: WHO, HTM/TB.
22.
go back to reference WHO. (2014). Global Tuberculosis Report 2014. World Health Organization. WHO. (2014). Global Tuberculosis Report 2014. World Health Organization.
23.
go back to reference Bekker, L.-G., & Wood, R. (2010). The changing natural history of tuberculosis and HIV coinfection in an urban area of hyperendemicity. Clinical Infectious Diseases, 50(Supplement 3), S208–S214.CrossRefPubMed Bekker, L.-G., & Wood, R. (2010). The changing natural history of tuberculosis and HIV coinfection in an urban area of hyperendemicity. Clinical Infectious Diseases, 50(Supplement 3), S208–S214.CrossRefPubMed
24.
go back to reference Godfrey-Faussett, P., et al. (2002). How human immunodeficiency virus voluntary testing can contribute to tuberculosis control. Bulletin of the World Health Organization, 80(12), 939–945.PubMed Godfrey-Faussett, P., et al. (2002). How human immunodeficiency virus voluntary testing can contribute to tuberculosis control. Bulletin of the World Health Organization, 80(12), 939–945.PubMed
25.
go back to reference Lawn, S. D., Torok, M. E., & Wood, R. (2011). Optimum time to start antiretroviral therapy during HIV-associated opportunistic infections. Current Opinion in Infectious Diseases, 24(1), 34–42.CrossRefPubMedPubMedCentral Lawn, S. D., Torok, M. E., & Wood, R. (2011). Optimum time to start antiretroviral therapy during HIV-associated opportunistic infections. Current Opinion in Infectious Diseases, 24(1), 34–42.CrossRefPubMedPubMedCentral
26.
go back to reference Badri, M., Wilson, D., & Wood, R. (2002). Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: A cohort study. Lancet, 359, 2059–2064.CrossRefPubMed Badri, M., Wilson, D., & Wood, R. (2002). Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: A cohort study. Lancet, 359, 2059–2064.CrossRefPubMed
27.
go back to reference Yee, D., et al. (2003). American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: Treatment of tuberculosis Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis. American Journal of Respiratory and Critical Care Medicine, 167, 603–662.CrossRef Yee, D., et al. (2003). American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: Treatment of tuberculosis Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis. American Journal of Respiratory and Critical Care Medicine, 167, 603–662.CrossRef
28.
go back to reference McIlleron, H., et al. (2012). Reduced antituberculosis drug concentrations in HIV-infected patients who are men or have low weight: Implications for international dosing guidelines. Antimicrobial Agents and Chemotherapy, 56(6), 3232–3238.CrossRefPubMedPubMedCentral McIlleron, H., et al. (2012). Reduced antituberculosis drug concentrations in HIV-infected patients who are men or have low weight: Implications for international dosing guidelines. Antimicrobial Agents and Chemotherapy, 56(6), 3232–3238.CrossRefPubMedPubMedCentral
29.
go back to reference Cella, D. F., et al. (1996). Development and validation of the functional assessment of human immunodeficiency virus infection (FAHI) quality of life instrument. Quality of Life Research, 5(4), 450–463.CrossRefPubMed Cella, D. F., et al. (1996). Development and validation of the functional assessment of human immunodeficiency virus infection (FAHI) quality of life instrument. Quality of Life Research, 5(4), 450–463.CrossRefPubMed
30.
go back to reference Verbeke, G., & Molenberghs, G. (2009). Linear mixed models for longitudinal data. New YorK: Springer. Verbeke, G., & Molenberghs, G. (2009). Linear mixed models for longitudinal data. New YorK: Springer.
31.
go back to reference Viala-Danten, M., et al. (2010). Psychometric evaluation of the functional assessment of HIV Infection (FAHI) questionnaire and its usefulness in clinical trials. Quality of Life Research, 19(8), 1215–1227.CrossRefPubMed Viala-Danten, M., et al. (2010). Psychometric evaluation of the functional assessment of HIV Infection (FAHI) questionnaire and its usefulness in clinical trials. Quality of Life Research, 19(8), 1215–1227.CrossRefPubMed
32.
go back to reference Wu, A. W., et al. (2004). Changes in quality of life during hemodialysis and peritoneal dialysis treatment: Generic and disease specific measures. Journal of the American Society of Nephrology, 15(3), 743–753.CrossRefPubMed Wu, A. W., et al. (2004). Changes in quality of life during hemodialysis and peritoneal dialysis treatment: Generic and disease specific measures. Journal of the American Society of Nephrology, 15(3), 743–753.CrossRefPubMed
33.
34.
go back to reference Call, S., et al. (2000). Health-related quality of life and virologic outcomes in an HIV clinic. Quality of Life Research, 9(9), 977–985.CrossRefPubMed Call, S., et al. (2000). Health-related quality of life and virologic outcomes in an HIV clinic. Quality of Life Research, 9(9), 977–985.CrossRefPubMed
35.
go back to reference Timilsina, S., & Regmi, K. (2015). Assessing quality of life and depression among people living with HIV/AIDS and TB–HIV coinfection in Kathmandu, Nepal. SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS, 11(2), 7–14.CrossRef Timilsina, S., & Regmi, K. (2015). Assessing quality of life and depression among people living with HIV/AIDS and TB–HIV coinfection in Kathmandu, Nepal. SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS, 11(2), 7–14.CrossRef
36.
go back to reference Akinboro, A.O., et al. (2014). Quality of life of Nigerians living with human immunodeficiency virus. The Pan African Medical Journal, 18, 234. Akinboro, A.O., et al. (2014). Quality of life of Nigerians living with human immunodeficiency virus. The Pan African Medical Journal, 18, 234.
37.
go back to reference Deribew, A., et al. (2013). Change in quality of life: A follow up study among patients with HIV infection with and without TB in Ethiopia. BMC Public Health, 13(408), 1471–2458. Deribew, A., et al. (2013). Change in quality of life: A follow up study among patients with HIV infection with and without TB in Ethiopia. BMC Public Health, 13(408), 1471–2458.
38.
go back to reference Venter, E., Gericke, G., & Bekker, P. (2009). Nutritional status, quality of life and CD4 cell count of adults living with HIV/AIDS in the Ga-Rankuwa area (South Africa): Original research. South African Journal of Clinical Nutrition, 3, 124–129.CrossRef Venter, E., Gericke, G., & Bekker, P. (2009). Nutritional status, quality of life and CD4 cell count of adults living with HIV/AIDS in the Ga-Rankuwa area (South Africa): Original research. South African Journal of Clinical Nutrition, 3, 124–129.CrossRef
39.
go back to reference Bauer, M., Leavens, A., & Schwartzman, K. (2013). A systematic review and meta-analysis of the impact of tuberculosis on health-related quality of life. Quality of Life Research, 22(8), 2213–2235.CrossRefPubMed Bauer, M., Leavens, A., & Schwartzman, K. (2013). A systematic review and meta-analysis of the impact of tuberculosis on health-related quality of life. Quality of Life Research, 22(8), 2213–2235.CrossRefPubMed
40.
go back to reference Ralph, A. P., et al. (2013). High morbidity during treatment and residual pulmonary disability in pulmonary tuberculosis: Under-recognised phenomena. PLoS One, 8(11), e80302.CrossRefPubMedPubMedCentral Ralph, A. P., et al. (2013). High morbidity during treatment and residual pulmonary disability in pulmonary tuberculosis: Under-recognised phenomena. PLoS One, 8(11), e80302.CrossRefPubMedPubMedCentral
41.
go back to reference Cella, D., Hahn, E., & Dineen, K. (2002). Meaningful change in cancer-specific quality of life scores: Differences between improvement and worsening. Quality of Life Research, 11(3), 207–221.CrossRefPubMed Cella, D., Hahn, E., & Dineen, K. (2002). Meaningful change in cancer-specific quality of life scores: Differences between improvement and worsening. Quality of Life Research, 11(3), 207–221.CrossRefPubMed
Metagegevens
Titel
Longitudinal assessment of health related quality of life of HIV infected patients treated for tuberculosis and HIV in a high burden setting
Auteurs
Thuli Mthiyane
Alex Pym
Keertan Dheda
Roxana Rustomjee
T. Reddy
Shamila Manie
Publicatiedatum
09-06-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 12/2016
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1332-4

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