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Journal of Autism and Developmental Disorders

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01-04-2012 | Original Paper

Long-term Cognitive and Behavioral Therapies, Combined with Augmentative Communication, are Related to Uncinate Fasciculus Integrity in Autism

Auteurs: Matteo Pardini, Maurizio Elia, Francesco G. Garaci, Silvia Guida, Filadelfo Coniglione, Frank Krueger, Francesca Benassi, Leonardo Emberti Gialloreti

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2012

Abstract

Recent evidence points to white-matter abnormalities as a key factor in autism physiopathology. Using Diffusion Tensor Imaging, we studied white-matter structural properties in a convenience sample of twenty-two subjects with low-functioning autism exposed to long-term augmentative and alternative communication, combined with sessions of cognitive and behavioral therapy. Uncinate fasciculus structural properties correlated significantly with therapy length and early onset, as well as to clinical outcome, independently from IQ, age or symptoms severity at therapy onset. Moreover, adherence to therapy was linked with better clinical outcome and uncinate fasciculus structural integrity. The results point to the capability of a long-term rehabilitation of subjects with low-functioning autism to produce white-matter structural modifications, which could thus play a role in the rehabilitative outcome.

vorige artikel Predictive and Concurrent Validity of Parent Concern About Young Children at Risk for Autism

volgende artikel Measuring Change in Social Interaction Skills of Young Children with Autism

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Titel: Long-term Cognitive and Behavioral Therapies, Combined with Augmentative Communication, are Related to Uncinate Fasciculus Integrity in Autism
Auteurs: Matteo Pardini
Maurizio Elia
Francesco G. Garaci
Silvia Guida
Filadelfo Coniglione
Frank Krueger
Francesca Benassi
Leonardo Emberti Gialloreti
Publicatiedatum: 01-04-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 4/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-011-1281-2

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