Introduction
Methods
Patients
Scintigraphy
Follow-up
Statistical Analysis
Results
On-site (n = 60) | Off-site (n = 68) |
p
| |
---|---|---|---|
Age (years) | 64 ± 11 | 61 ± 12 | 0.62 |
Men | 44 (73%) | 49 (72%) | 0.87 |
Diabetes mellitus | 4 (7%) | 2 (3%) | 0.32 |
Smoker | 24 (40%) | 33 (49%) | 0.59 |
Hypertension | 15 (25%) | 20 (29%) | 0.58 |
Family history of CVD | 27 (45%) | 28 (41%) | 0.66 |
Previous PCI | 2 (3%) | 2 (3%) | 0.90 |
Previous CABG | 3 (5%) | 2 (3%) | 0.55 |
Killip class >1 | 1 (1%) | 1 (2%) | 0.92 |
Summed ST deviation (mm) | 15 ± 12 | 17 ± 9 | 0.27 |
Anterior myocardial infarction | 23 (38%) | 26 (38%) | 0.99 |
Q wave | 32 (53%) | 42 (62%) | 0.24 |
Multi (>1) vessel disease | 23 (38%) | 28 (41%) | 0.74 |
TIMI flow pre PCI <2 | 38 (67%) | 51 (75%) | 0.31 |
TIMI flow post PCI <2 | 1 (2%) | 2 (3%) | 0.67 |
Symptoms-to-admission (min) | 158 ± 131 | 163 ± 201 | 0.87 |
Symptoms-to-balloon (min) | 286 ± 146 | 257 ± 211 | 0.38 |
Symptoms-to-arrival (min) | 158 ± 131 | 163 ± 201 | 0.87 |
Door-to-balloon (min) | 125 ± 59 | 94 ± 54 | 0.003 |
Time-to-treatment (min) | 286 ± 146 | 257 ± 211 | 0.39 |
Time to Treatment and Centre of Randomisation
On-site (n = 60) | Off-site (n = 68) |
p
| |
---|---|---|---|
Death or infarct | 11 (18%) | 14 (21%) | 0.75 |
LVESV (ml) | 58 ± 26 | 65 ± 31 | 0.17 |
LVEDV (ml) | 118 ± 36 | 124 ± 38 | 0.34 |
LVEF (%) | 52 ± 12 | 50 ± 11 | 0.06 |
Infarct extent (%) | 14 ± 12 | 17 ± 15 | 0.34 |
SRS | 11 ± 9.6 | 12 ± 12 | 0.33 |
SMS | 19 ± 13 | 24 ± 20 | 0.06 |
STS | 14 ± 12 | 17 ± 15 | 0.028 |
Peak CK | 1611 ± 1838 | 1894 ± 1609 | 0.35 |
Peak CK-MB (U/l) | 161 ± 136 | 204 ± 160 | 0.11 |
Scintigraphic Data and Centre of Randomisation
Scintigraphic Data and 5-Year Clinical Outcome
Crude hazard ratio and 95% CI | Multivariate adjusted hazard ratio and 95% CI |
P value | |
---|---|---|---|
Off-site centre | 1.2 (0.53–2.6) | 1.3 (0.56–3.2) | 0.51 |
Age (years) | 1.03 (0.99–1.06) | 1.03 (0.99–1.1) | 0.14 |
Men | 1.0 (0.42–2.4) | – | |
Diabetes mellitus | 3.2 (0.97–11) | 2.5 (0.63–9.7) | 0.20 |
Smoker | 1.3 (0.72–2.2) | 1.3 (0.74–2.3) | 0.36 |
Hypertension | 1.3 (0.54–2.9) | – | |
Family history of CVD | 0.60 (0.26–1.4) | 0.76 (0.31–1.8) | 0.54 |
Previous PCI | 0.05 (0–600) | – | |
Previous CABG | 1.1 (0.15–8.3) | – | |
Killip class >1 | 2.8 (0.38–21) | 25.1 (2.0–315) | 0.013 |
Summed ST deviation (mm) | 1.03 (0.72–1.5) | – | |
Anterior myocardial infarction | 1.3 (0.60–2.9) | 1.4 (0.49–4.0) | 0.54 |
Q wave | 3.1 (1.2–8.4) | 3.4 (1.02–11.2) | 0.046 |
Multi-vessel disease (>1) | 1.1 (0.49–2.4) | – | |
TIMI flow pre PCI <2 | 1.2 (0.51–2.8) | – | |
TIMI flow post PCI <2 | 0.46 (0.06–3.4) | 0.75 (0.08–7.3) | 0.80 |
Symptoms-to-admission (h) | 1.06 (0.96–1.16) | 0.94 (0.61–1.5) | 0.79 |
Door-to-balloon (h) | 1.01 (0.68–1.5) | – | |
Time-to-treatment (h) | 1.05 (0.96–1.15) | 1.09 (0.71–1.7) | 0.69 |
LVESV (10 ml) | 1.02 (0.90–1.2) | – | |
LVEDV (10 ml) | 1.01 (0.91–1.1) | – | |
LVEF (%) | 1.0 (0.97–1.03) | – | |
Infarct extent (%) | 1.02 (0.99–1.04) | 1.0 (0.82–1.2) | 0.97 |
SRS | 1.02 (0.99–1.05) | 1.03 (0.80–1.3) | 0.83 |
SMS | 1.01 (0.99–1.03) | 1.03 (0.95–1.1) | 0.50 |
STS | 1.01 (0.99–1.03) | 0.95 (0.86–1.1) | 0.35 |