Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010, 154(3):227-233 | DOI: 10.5507/bp.2010.034

ASSOCIATION BETWEEN LABORATORY MARKERS AND PRESENCE OF CORONARY ARTERY DISEASE

Vladimir Kincl^a, Roman Panovsky^a, Jaroslav Meluzin^a, Jiri Semenka^a, Ladislav Groch^a, Daniela Tomcikova^b, Jiri Jarkovsky^b, Ladislav Dusek^b

^a Ist Department of Internal Medicine-Cardioangiology, St. Ann Faculty Hospital, Masaryk University and International Clinical Research Center, Pekarska 53, 656 91 Brno, Czech Republic

^b Institute of Biostatistics and Analyses, Masaryk University, Kamenice 3, Brno

The aim of this paper is to elucidate the relation between laboratory markers and coronary artery disease (CAD).

Methods: The study involved 1254 consecutive patients with suspected or known CAD referred for coronary angiography. The blood samples including blood cell count, C-reactive protein, fibrinogen, uric acid, creatinine, and lipid spectrum were obtained after overnight fasting. One hundred and thirty-three patients were excluded due to incomplete records or inacceptable laboratory values. Differences among groups were tested with one-way ANOVA and Bonferroni post-hoc test for continuous variables and with chi-square test for categorical variables. Univariate and multivariate logistic regression was adopted for the analysis of risk factors and development of models for classification of patients into clinical categories.

Results: The linear logistic regression showed association of patient's biochemical markers with the presence of disease. Both acute and chronic CAD were associated with leukocyte count (Odds ratios 1.45 and 1.26), CRP (1.13; 1.05), fibrinogen (4.23; 1.95), uric acid (1.27; 1.38), creatinine (1.04; 1.04), HDL cholesterol (0.07; 0.12), triglycerides (1.4; 1.52) and glucose (1.56; 1.39). Presence of insignificant atherosclerosis was influenced only by fibrinogen (OR 1.73), creatinine (1.02), HDL cholesterol (0.5) and glucose level (1.23). There was no difference between one- and multivessel disease in laboratory values.

Conclusion: Leukocyte count, CRP level, triglycerides and uric acid are associated with the presence of both acute and chronic ischaemic heart disease, but not with number of stenosed vessels. In addition, glycemia, HDL cholesterol and namely fibrinogen and creatinine have relation to occurence of insignificant atherosclerosis.

Keywords: Coronary artery disease, Laboratory markers, Atherosclerosis

Received: March 19, 2010; Accepted: July 1, 2010; Published: September 1, 2010  Show citation